Farmacia Journal 6/2016

Volume 64 | Number 6 | Year 2016

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AROMATASE INHIBITORS IN MEN – OFF-LABEL USE, MISUSE, ABUSE AND DOPING

CAMIL-EUGEN VARI¹, BIANCA-EUGENIA ŐSZ^1*, AMALIA MIKLOS², ANCA BERBECARUIOVAN⁴, AMELIA TERO-VESCAN³

1.Pharmacology and Clinical Pharmacy Department, Faculty of Pharmacy, University of Medicine and Pharmacy Tîrgu Mureş, Romania
2.Advanced Medical and Pharmaceutical Research Centre (CCMAF), Faculty of Pharmacy, University of Medicine and Pharmacy Tîrgu Mureş, Romania
3.Biochemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy Tîrgu Mureş, Romania
4.Faculty of Pharmacy, University of Medicine and Pharmacy, 2 Petru Rareş, 200349, Craiova, Romania

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EFFECTS OF CORTICOSTEROID TREATMENT ON RESPIRATORY MUSCLES FUNCTION IN PATIENTS WITH SEVERE OBSTRUCTIVE LUNG DISEASE

AGRIPINA RAȘCU^1,2, DANIELA ELENA POPA^3*, OANA CRISTINA ARGHIR⁴, MARINA RUXANDRA OȚELEA¹

1.“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2.Colentina University Hospital, Clinic of Occupational Medicine, Bucharest, Romania
3.Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
4.Faculty of Medicine, “Ovidius” University, Constanţa, Romania

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BIOEQUIVALENCE IMPLIES THERAPEUTIC EQUIVALENCE. I. BIOSTATISTICAL APPROACH

FLORENTINA GHERGHICEANU¹, ROXANA SANDULOVICI², IRINA PRASACU^3*, VALENTINA ANUȚA³, CONSTANTIN MIRCIOIU³

1.PhD student, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2.Faculty of Pharmacy, “Titu Maiorescu” University, Bucharest, Romania
3.Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

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NEW SYNTHESIS IN THE N-[4-[(PHENYLCARBAMOYL)AMINO]- PHENYL]BENZENESULFONAMIDE DERIVATIVES SERIES. NOTE 1

IOANA DANA ROTARU (ENACHE)¹, DIANA CAMELIA NUȚĂ^1*, ILEANA CORNELIA CHIRIŢĂ¹, MIRON TEODOR CĂPROIU², CARMEN LIMBAN¹, ALEXANDRU VASILE MISSIR¹, CORNEL CHIRIȚĂ¹

1.”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, Romania, 6 Traian Vuia St., Bucharest, 020956, Romania
2.”C. D. Neniţescu” The Organic Chemistry Centre of Romanian Academy, 202B Splaiul Independenţei, Bucharest, Romania

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NEW LC-MS/MS METHOD FOR TESTOSTERONE AND DIHYDROTESTOSTERONE ANALYSIS IN MALE RAT PLASMA

LAURIAN VLASE¹, SILVIA IMRE^2*, DANIELA-LUCIA MUNTEAN², BIANCA ŐSZ², AMALIA MIKLOS², AMELIA TERO-VESCAN², CAMIL-EUGEN VARI²

1.Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012, Cluj-Napoca, Romania
2.Faculty of Pharmacy, University of Medicine and Pharmacy, 39 Gheorghe Marinescu Street, 540139, Târgu Mureş, Romania

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PHYTOCHEMICAL PROFILE OF TWO CULTIVATED PELARGONIUM (GERANIACEAE) SPECIES

CRISTINA ELENA IANCU, OANA CIOANCĂ*, MONICA HĂNCIANU, CORNELIA MIRCEA

“Gr. T. Popa” University of Medicine and Pharmacy Iaşi, Faculty of Pharmacy, Department of Pharmacognosy, 16 Universității, Iași, Romania

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IN VITRO P-GP EXPRESSION AFTER ADMINISTRATION OF CNS ACTIVE DRUGS

ALINA CRENGUȚA NICOLAE ^1#, ANDREEA LETIȚIA ARSENE ^2#*, VLAD VUȚĂ ^3#, DANIELA ELENA POPA ^4#, CARMEN ADELLA SÎRBU ^5#, GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU ^4#, ION-BOGDAN DUMITRESCU ^6#, BRUNO ȘTEFAN VELESCU ^7#, ELIZA GOFIȚĂ ^8#, CRISTINA MANUELA DRĂGOI ^1#

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Biochemistry, 6 Traian Vuia Street, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Microbiology, 6 Traian Vuia Street, Bucharest, Romania
3.Institute for Diagnosis and Animal Health, Department of Virology, Bucharest, Romania
4.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Drug Control, 6 Traian Vuia Street, Bucharest, Romania
5.“Carol Davila” Central University Emergency Military Hospital, Department of Neurology, 134 Calea Plevnei Street, Bucharest, Romania
6.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Physics and Informatics, 6 Traian Vuia Street, Bucharest, Romania
7.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
8.University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Toxicology, 2 Petru Rareș Street, 200349, Craiova, Romania

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PROTECTION MECHANISM OF ERYTHROPOIETIN ON CERAMIDE-INDUCED RETINAL DAMAGE

CHENG QIAN, GUANGMING WAN, WENZHAN WANG, PANSHI YAN, SHENZHI LIANG, YU ZHU*

Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China

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QUALITATIVE ASSAY OF ESSENTIAL OILS OF LAVENDER AND PEPPERMINT IN COMMERCIAL PRODUCTS THROUGH SPECTRAL AND CHROMATOGRAPHIC METHODS

SILVIA IMRE¹, SIGRID EŞIANU¹, AMALIA MIKLOS^1*, IOANA TIUCA², IONELA DICHER¹, AMELIA TERO-VESCAN¹, DANIELA-LUCIA MUNTEAN¹, RADU OPREAN²

1.University of Medicine and Pharmacy Tîrgu Mureş, Faculty of Pharmacy, 38 Gheorghe Marinescu Street, 540139, Târgu Mureş, Romania
2.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, 4 Pasteur Street, 400349, Cluj-Napoca, Romania

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EVALUATION OF POLYPHENOLIC PROFILE AND ANTIOXIDANT ACTIVITY FOR CYTISUS NIGRICANS AND CYTISUS ALBUS

DANIELA HANGANU¹, LORENA FILIP¹, NELI-KINGA OLAH², ANDREI MOCAN¹, LAURIAN VLASE^1*, OANA RAITA³, ILIOARA ONIGA¹, DANIELA BENEDEC¹

1.Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 I. Creangă Street, 400010, Cluj-Napoca,
Romania
2.Faculty of Pharmacy, “Vasile Goldiș” West University of Arad, 86 L. Rebreanu Street, Arad, Romania; SC PlantExtrakt SRL, Rădaia, Jud. Cluj, Romania
3.National Institute for Research and Development of Isotopic and Molecular Technologies, 1 Donath Street, Cluj-Napoca, Romania

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PHARMACOLOGICAL AND CLINICAL ASPECTS OF EFFICACY, SAFETY AND TOLERABILITY OF ATYPICAL ANTIPSYCHOTIC MEDICATION IN CHILD AND ADOLESCENT PATIENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDERS

LAURA NUSSBAUM ^1#*, NICOLETA ANDREESCU ^2#, LAVINIA MARIA HOGEA ^3#, CĂLIN MUNTEAN ^4#, RADU ȘTEFĂNESCU⁵, MARIA PUIU²

1.Pedopsychiatry Discipline, Department of Neurosciences, “Victor Babeș” University of Medicine and Pharmacy, 2 E. Murgu Square, Timișoara, Romania
2.Genetics Discipline, Microscopic Morphology Department, “Victor Babeș” University of Medicine and Pharmacy, 2 E. Murgu Square, Timișoara, Romania
3.Psychology Discipline, Department of Neurosciences, “Victor Babeș” University of Medicine and Pharmacy, 14 T. Vladimirescu Street, Timișoara, Romania
4.Discipline of Informatics and Medical Biostatistics, Department of Functional Sciences, “Victor Babeș” University of Medicine and Pharmacy, 14 T. Vladimirescu Street, Timișoara, Romania
5.“Titu Maiorescu” University, School of Medicine, Bucharest, Romania

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SCREENING OF THIOALKANOIC SUBSTITUTED 1,4- NAPHTHOQUINONES AS POTENT ANTIMICROBIAL AGENTS

GABRIELA RĂU ^1#, FLAVIA MARIA CREŢU ^1#, ANCA BERBECARU-IOVAN ^1#*, CAMELIA ELENA STĂNCIULESCU¹, ANA MARINA ANDREI¹, GEORGE DAN MOGOŞANU¹, MARIA BĂLĂŞOIU^1,2, ILEANA MONICA BANIŢĂ^1,3, CĂTĂLINA GABRIELA PISOSCHI^1,2

1.University of Medicine and Pharmacy, 2-4 Petru Rareş, 200349, Craiova, Dolj, Romania
2.Clinical Laboratory, Emergency Clinical County Hospital, 1 Tabaci, 200642, Craiova, Dolj, Romania
3.Clinical Laboratory, Clinical Hospital of Neuropsychiatry, 99 Calea București, 200473, Craiova, Dolj, Romania

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CONJUGATED LINOLENIC ACID CONTENT IN SEEDS OF SOME POT MARIGOLD (CALENDULA OFFICINALIS L.) CULTIVARS GROWN IN POLAND

BEATA KRÓL^1*, TADEUSZ PASZKO², ANNA KRÓL³

1.University of Life Sciences, Faculty of Agrobioengineering, Department of Industrial and Medicinal Plants, Akademicka 15, 20-950 Lublin, Poland
2.University of Life Sciences, Faculty of Food Science and Biotechnology, Department of Chemistry, Akademicka 15, 20-950 Lublin, Poland
3.University of Medical Sciences, Department of Biochemistry and Molecular Biology, Poznań 6 Święcickiego St., 60-781 Poznań, Poland

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SYNTHESIS, CHARACTERIZATION AND MICROBIOLOGICAL ACTIVITY EVALUATION OF NOVEL HARD GELATINE CAPSULES WITH CEFACLOR AND PIROXICAM

GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU ^1#, DANIELA ELENA POPA ^1#*, BRUNO ȘTEFAN VELESCU ^2#, ADRIAN ANDRIEȘ ³, VIOREL ORDEANU ⁴, ALINA CRENGUȚA NICOLAE ^5#, CRISTINA MANUELA DRĂGOI ^5#, MARIA BÂRCĂ ^1#, OCTAV GINGHINĂ ^6#

1.Department of Drug Control, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
3.Department of Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
4.Scientific Military Medical Research Centre, 88 Mircea Vulcănescu Street, 010825, Bucharest, Romania
5.Department of Biochemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
6.Department of Oncological Surgery, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, “Sf. Ioan” Hospital, 13 Vitan-Bârzești Street, 042122, Bucharest, Romania

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SYNTHESIS OF WATER SOLUBLE L-ALANIN-CALIX[N]ARENES AND THEIR COMPLEX FORMATION STUDY WITH WARFARIN AND ACENOCOUMAROL

IOANA TIUCA^1*, KATALIN NAGY¹, ADRIANA HANGAN², RADU OPREAN¹

1.Department of Analytical Chemistry, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 4 Louis Pasteur Street, Cluj-Napoca, Romania
2.Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 Ion Creangă Street, Cluj-Napoca, Romania

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DEVELOPMENT OF MICROEMULSION-LOADED HYDROGEL FORMULATIONS FOR TOPICAL DELIVERY OF METOPROLOL TARTRATE: PHYSICOCHEMICAL CHARACTERIZATION AND EX VIVO EVALUATION

LAVINIA VLAIA ^1#, IOANA OLARIU ^1#, GEORGETA CONEAC^1*, ANA MARIA MUŢ¹, CĂLIN POPOIU², STĂNCIULESCU CORINA², DAN FLORIN ANGHEL³, MONICA ELISABETA MAXIM³, SAMI KALAS⁴, VICENŢIU VLAIA⁵

1.“Victor Babeş” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
2.“Victor Babeş” University of Medicine and Pharmacy, Faculty of Medicine, Department of Pediatrics, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
3.“Ilie Murgulescu” Institute of Physical Chemistry of the Romanian Academy, Laboratory of Colloid Chemistry, 202 Splaiul Independenţei, 060021, Bucharest, Romania
4.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 6th Traian Vuia Street, 020956, Bucharest, Romania
5.“Victor Babeş” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, 2 Eftimie Murgu Square, 300041, Timişoara, Romania

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LAVANDULA HYBRIDA: MICROSCOPIC CHARACTERIZATION AND THE EVALUATION OF THE ESSENTIAL OIL

SILVIA ROBU¹, BIANCA IOANA CHESARU^1*, CAMELIA DIACONU¹, OLIMPIA DUMITRIUBUZIA¹, DANA TUTUNARU¹, URSULA STANESCU², ELENA LACRAMIOARA LISA¹

1.Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galați, Romania
2.Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania

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ORIGINAL CLINICAL EXPERIENCE AND APPROACH TO TREATMENT STUDY WITH INTERLEUKINE 12/23 INHIBITOR IN MODERATE-TO-SEVERE PSORIASIS PATIENTS

RODICA OLTEANU¹, MARIA-MAGDALENA CONSTANTIN^1,2*, ALEXANDRA ZOTA¹, DANMIHAI DOROBANȚU¹, TRAIAN CONSTANTIN², ELENA-DANIELA ȘERBAN¹, PAUL BĂLĂNESCU¹, DANA MIHELE², LAURA GHEUCĂ SOLOVĂSTRU³

1.Colentina Clinical Hospital, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3.“Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

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SYNTHESIS, CHARACTERIZATION AND MICROBIOLOGICAL ACTIVITY EVALUATION OF TWO SILVER COMPLEXES WITH NORFLOXACIN

AURA RUSU¹, GABRIEL HANCU^1*, GERGŐ TÓTH², FELICIA TOMA³, ANCA DELIA MARE³, ADRIAN MAN³, BRUNO ŞTEFAN VELESCU⁴, VALENTINA UIVAROȘI⁵

1.University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Pharmaceutical Chemistry Department, 38 Gheorghe Marinescu Street, Tîrgu Mureș, 540139, Romania
2.Semmelweis University, Pharmaceutical Chemistry Department, 9 Hőgyes Endre Street, Budapest, H-1092, Hungary
3.University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Medicine, Microbiology, Virology, and Parasitology Department, 38 Gheorghe Marinescu Street, Tîrgu Mureș, 540139, Romania
4.”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacology and Clinical Pharmacy Department, 6 Traian Vuia Street, 2 District, Bucharest, 020956, Romania
5.”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, General and Inorganic Chemistry Department, 6 Traian Vuia Street, 2 District, Bucharest, 020956, Romania

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NEW ACYL-OXIMINE DERIVATIVES SYNTHESIS AND THEIR PRELIMINARY PHARMACOTOXICOLOGICAL INVESTIGATION

DANA MIHAELA CIOROIANU¹, CORNEL CHIRIŢĂ^2*, CARMEN LIMBAN¹, ALEXANDRU VASILE MISSIR¹, ILEANA CORNELIA CHIRIŢĂ¹, MIRON TEODOR CĂPROIU³, SIMONA NEGREŞ², FLORIANA ELVIRA IONICĂ⁴, DIANA CAMELIA NUŢĂ¹

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 6 Traian Vuia Street, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
3.The Organic Chemistry Centre of Romanian Academy “C. D. Neniţescu”, 202B Splaiul Independenţei, Bucharest, Romania
4.University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology, 2-4 Petru Rareș Street, Craiova, Romania

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THERMAL STABILITY ASSESMENT OF AMIODARONE HYDROCHLORIDE IN POLYMERIC MATRIX TABLETS

ANDREEA CREȚEANU¹, LĂCRĂMIOARA OCHIUZ^1*, CORNELIA VASILE², OANA MARIA PĂDURARU², CRISTINA POPESCU², MĂDĂLINA VIERU¹, ALINA DIANA PANAINTE¹, GLADIOLA ȚÂNTARU¹

1.Faculty of Pharmacy, “Gr. T. Popa” University of Medicine and Pharmacy, 15 Universității Street, 700115, Iași, Romania
2.“Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Vodă Alley, 700487, Iași, Romania

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ETIOLOGICAL DIAGNOSIS AND PHARMACOTHERAPEUTIC MANAGEMENT OF PARAPNEUMONIC PLEURISY

DANIELA CĂLINA ^1#, LUCICA ROȘU ^2#, ALEXANDRA FLORIANA ROȘU ^3#, GABRIEL IANOŞI ^4#, SIMONA IANOŞI ^5#, OVIDIU ZLATIAN ^2#, RADU MITRUȚ ^6#, ANCA OANA DOCEA ^7#*, OTILIA ROGOVEANU ^8#, PAUL MITRUȚ ^9#, ALINA CRENGUȚA NICOLAE ^10#, CRISTINA MANUELA DRĂGOI ^10#, ELIZA GOFIȚĂ ^7#

1.Clinical Pharmacy Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
2.Microbiology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
3.Internal Medicine Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
4.Surgery Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
5.Dermatology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
6.Pathology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
7.Toxicology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
8.Physiotherapy Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
9.Internal Medicine Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania
10.Biochemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

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PHARMACEUTICAL MANAGEMENT TRAINING: MULTISTAGE RESEARCH IN POLAND AND UKRAINE

MARIIA GOVORUKHA¹, OLESYA HULCHIY¹, STELA ADAUJI^2*

1.National Medical Academy of Post-Graduate Education Named After P.L. Shupik, Ministry of Health of Ukraine, Dorohozhytska Street, 9, 04112, Kiev, Ukraine
2.“Vasile Procopişin” Department of Social Pharmacy, Faculty of Pharmacy, “Nicolae Testemitanu” State University of Medicine and Pharmacy, 165 Stefan cel Mare si Sfant Street, MD 2004, Chisinau, Republic of Moldova

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THE ELABORATION OF NOVEL ANALYTICAL METHODS FOR CLEMASTINE AND TIMOLOL

ALEXANDRA FILARETA NEAGU ^*#, IOANA CLEMENTINA CONSTANTINESCU ^#

“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Analytical Chemistry, 6 Traian Vuia Street, 020956, Bucharest, Romania

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THE PHARMACIST'S ROLE IN PREVENTIVE AND PHARMACEUTICAL TREATMENT FOR ORAL DISEASES

MIHAELA ADINA DUMITRACHE¹, ECATERINA IONESCU¹, RUXANDRA SFEATCU^1*, OCTAV GINGHINA¹, GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU², ANA PETRE¹

1.Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 1, Bucharest, Romania
2.Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, District 1, Bucharest, Romania

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