Romanian Society of Pharmaceutical Sciences
 

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EFFECTS OF CORTICOSTEROID TREATMENT ON RESPIRATORY MUSCLES FUNCTION IN PATIENTS WITH SEVERE OBSTRUCTIVE LUNG DISEASE

AGRIPINA RAȘCU1,2, DANIELA ELENA POPA3*, OANA CRISTINA ARGHIR4, MARINA RUXANDRA OȚELEA1

1.“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2.Colentina University Hospital, Clinic of Occupational Medicine, Bucharest, Romania
3.Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
4.Faculty of Medicine, “Ovidius” University, Constanţa, Romania

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Glucocorticoids have remodelled the treatment of patients with obstructive lung disease (OLD) because they target inflammation, as they represent one of their pathogenic mechanisms. The current therapeutic indications are asthma and chronic obstructive bronchopulmonary disease (COPD), the severe form and the frequent exacerbation phenotypes, the eosinophilic predominant inflammation subtype. Through knowledge of the possible adverse effects of long acting inhaled corticosteroids, regarding the reduction of long-term respiratory muscle performance, could lead to the development of new therapeutic approaches, meant to increase the survival rate and the quality of life in patients with obstructive pulmonary disease.