Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS, CHARACTERIZATION AND MICROBIOLOGICAL ACTIVITY EVALUATION OF NOVEL HARD GELATINE CAPSULES WITH CEFACLOR AND PIROXICAM

GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU 1#, DANIELA ELENA POPA 1#*, BRUNO ȘTEFAN VELESCU 2#, ADRIAN ANDRIEȘ 3, VIOREL ORDEANU 4, ALINA CRENGUȚA NICOLAE 5#, CRISTINA MANUELA DRĂGOI 5#, MARIA BÂRCĂ 1#, OCTAV GINGHINĂ 6#

1.Department of Drug Control, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
3.Department of Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
4.Scientific Military Medical Research Centre, 88 Mircea Vulcănescu Street, 010825, Bucharest, Romania
5.Department of Biochemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
6.Department of Oncological Surgery, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, “Sf. Ioan” Hospital, 13 Vitan-Bârzești Street, 042122, Bucharest, Romania

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Cefaclor and piroxicam combination is relevant for the pharmaceutical field due to synergistic bactericidal and antiinflammatory potential, provided by the second generation cephalosporin and first generation NSAID. In order to obtain new products with higher pharmacological properties, we developed hard gelatine capsules with cefaclor and piroxicam, in a fixed-dose combination. A multi-analytical approach was carried out by Fourier Transform-Infrared Spectroscopy (FT-IR) and Thin Layer Chromatography (TLC). The screening of the antimicrobial activity of the capsules was performed by determination of the minimal inhibitory concentration (MIC) through microtiter broth dilution method.