Current Issue
Volume 69 | Number 6 Year 2021
Download this issue’s covers, announcements and author index.
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POSSIBLE MUTATION PATHWAYS IN SARS-CoV-2
MUHAMMAD TOREQUL ISLAM 1, CRISTINA QUISPE 2, JESÚS HERRERA-BRAVO 3,4, ISHAQ N. KHAN 5, SAUD SALEM BAWAZEER 6, MANOJ KUMAR 7, NATÁLIA CRUZ-MARTINS 8,9,10, MIQUEL MARTORELL 11, ANCA OANA DOCEA 12*, JAVAD SHARIFI-RAD 13, SEVGI DURNA DAŞTAN 14,15, DOINA DRĂGĂNESCU 16, ANDREEA LETIȚIA ARSENE 17, DANIELA CĂLINA 18
1Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka) 8100, Bangladesh
2Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
3Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
4Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile
5Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, 25120, Pakistan
6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 42, Saudi Arabia
7Chemical and Biochemical Processing Division, ICAR – Central Institute for Research on Cotton Technology, Mumbai400019, India
8Faculty of Medicine, University of Porto, Porto, Portugal
9Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
10Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal
11Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386 Concepción, Chile
12Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
13Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
14Department of Biology, Faculty of Science, Sivas Cumhuriyet University, 58140, Sivas, Turkey
15Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, 58140, Sivas, Turkey
16Department of Pharmaceutical Physics and Informatics, “Carol Davila” University of Medicine and Pharmacy, 020956, Bucharest, Romania
17Department of General and Pharmaceutical Microbiology, “Carol Davila” University of Medicine and Pharmacy, 020956,
Bucharest, Romania
18Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania -
OCULAR DRUG DELIVERY SYSTEMS: A REVIEW
LAURA MACOVEI 1,3#, ALINA GHEORGHE 1,2*, SPERANTA SCHMITZER 1,2#, MARIAN BURCEA 1,2#, MATEI MOROSANU 2
1“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
2 Emergency Ophthalmology Hospital Bucharest, 1 Lahovari Square, 010464, Bucharest, Romania
3“Carol Davila” Central Military Emergency Hospital, 010825, Bucharest, Romania -
COMPUTATIONAL ASSESSMENT OF THE PHARMACOKINETICS AND TOXICITY OF THE INTENSIVE SWEETENERS
DENISA IOANA VOICULESCU, VASILE OSTAFE, ADRIANA ISVORAN *
Department of Biology-Chemistry and Advanced Environmental Research Laboratories, Faculty of Chemistry, Biology,
Geography, West University of Timișoara, Romania -
PLANT PRODUCTS AND THEIR INHIBITORY ACTIVITY AGAINST XANTHINE OXIDASE
USAMAH SAYED 1, MOHAMMAD HUDAIB 2,3, ALA ISSA 3, KHALED TAWAHA 3, YASSER BUSTANJI 4,5*
1Department of Biological Sciences, School of Science, The University of Jordan, Amman, Jordan
2College of Pharmacy, Al Ain University of Science and Technology, Abu Dhabi 112612, UAE
3School of Pharmacy, The University of Jordan, Amman, Jordan
4Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE 5Hamdi Mango Center for Scientific Research, The University of Jordan, Amman, Jordan -
CARDIOTOXICITY OF ANTICANCER THERAPIES: FOCUS ON THE ROLE OF THE CARDIO-ONCOLOGICAL TEAM. A PRACTICAL REVIEW
GABRIELA SILVIA GHEORGHE 1,2, ANA CIOBANU 1,2*, ANDREEA SIMONA HODOROGEA 1,2, ANDREI CRISTIAN DAN GHEORGHE 1,2, RĂZVAN VALENTIN SCĂUNAȘU 1,3, IOAN TIBERIU NANEA 1,2, MARINELA IONELA STOIAN 1,4, ADRIANA MIHAELA ILIESIU 1,2
1Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2Department of Internal Medicine and Cardiology, “Theodor Burghele” Clinical Hospital, Bucharest, Romania
3Department of General Surgery, Colțea Clinical Hospital, Bucharest, Romania
4Department of Cardiology, University and Emergency Hospital, 169 Splaiul Independenței, 050098, Bucharest, Romania -
INFLUENCE OF BETAMETHASONE DIPROPIONATE AND PREDNISONE ON ENZYME KINETICS
SAFIJA HERENDA 1*, MIRSAD CRNKIĆ 1, LEJLA KLEPO 1, EDHEM HASKOVIĆ 2, DENIS
HASKOVIĆ 3, ENA DELJKIĆ 41Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
2Department of Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
3Clinical Center of the University of Sarajevo Organizational unit clinical pathology, cytology and human genetics, Sarajevo, Bosnia and Herzegovina
4Clinical Center of the University of Sarajevo, Organizational unit clinical biochemistry with immunology, Sarajevo, Bosnia and Herzegovina -
EVALUATING THE CAPACITY OF HUMAN SERUM ALBUMIN TO REDUCE NON-SPECIFIC BINDING OF MELOXICAM IN THE ULTRAFILTRATION PROCESS
SILVIA IMRE 1,2, CAMELIA-MARIA TOMA 1,2*, CAMIL-EUGEN VARI 3
1Department of Analytical Chemistry and Drug Analysis, Faculty of Pharmacy, “George Emil Palade” University of Medicine,
Pharmacy, Science, and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, RO-540142, Târgu Mureș, Romania
2Center of Advanced Medical and Pharmaceutical Research, “George Emil Palade” University of Medicine, Pharmacy,
Science, and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, RO-540142, Târgu Mureș, Romania
3Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, RO-540142, Târgu Mureș, Romania -
THE IN VITRO RELEASE TESTING AND THE ANTIMICROBIAL ACTIVITY OF SEMI-SOLID DOSAGE FORMS WHICH CONTAIN SALICYLIC ACID
YELIZAVETA ZUIKINA 1,2*, NATALIA POLOVKO 2, OKSANA STRILETS 3, LEONID STRELNIKOV 3
1Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences Sukilėlių pr. 13, Kaunas,
Lithuania
2Department of Pharmaceutical Technology of Drugs, National Unıversity of Pharmacy, Valentinovska Street, Kharkiv, Ukraine
3Department of Biotechnology, National Unıversity of Pharmacy, Valentinovska Street, Kharkiv, Ukraine -
HYPERICUM SP. EXTRACTS IMPROVE ANXIETY-LIKE BEHAVIOUR AND INFLUENCE CEREBRAL HMOX1 EXPRESSION IN A RAT MODEL OF FG-7142 – INDUCED ANXIETY
ALEXANDRA C. SEVASTRE-BERGHIAN 1#, VLAD A. TOMA 2, BOGDAN SEVASTRE 3, DANIELA BENEDEC 4, ILIOARA ONIGA 4, LORENA FILIP 4#, IOANA BÂLDEA 1, ŞOIMIŢA SUCIU 1, CRISTIAN PAUL POPOVICI 3, ROXANA LIANA LUCACIU 4, NICOLETA DECEA 1, SIMONA V. CLICHICI 1, IRINA IELCIU 4, GABRIELA A. FILIP 1*, DANIELA HANGANU 4
1Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 1 Clinicilor Street, 400006, Cluj-Napoca,
Romania
2NIRD for Isotopic and Molecular Technologies, Department of Molecular and Biomolecular Physics, 101 Donat Street, Cluj-Napoca, Romania
3Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 3-5 Mănăștur Street, 400372, Cluj-Napoca, Romania
4Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, ClujNapoca, Romania -
RESEARCH REGARDING THE EFFECT OF LEPTIN UPON THE RATIO OF CERTAIN LYMPHOCYTE POPULATIONS IN RAT
MARIAN GHIȚĂ 1, RĂZVAN BOTEZATU 2, CRISTIN COMAN 3, VLAD VUȚĂ 4*, GABRIEL GÂJÂILĂ 1, ALINA CRENGUȚA NICOLAE 5, CRISTINA MANUELA DRĂGOI 5, GABRIEL COTOR 1
1University of Agronomic Sciences and Veterinary Medicine, 59 Mărăşti Boulevard, 011464, Bucharest, Romania 2Centrovet Veterinary Center, 52-54 Pascal Aristide Street, 031443, Bucharest, Romania
3“Cantacuzino” National Medico-Military for Research and Development Institute, 103 Splaiul Independenței, 050096, Bucharest, Romania
4Institute for Diagnosis and Animal Health, 63 Dr. Staicovici Street, 050557, Bucharest, Romania
5“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Biochemistry Department, 020956, Bucharest, Romania -
ENDOPLASMIC RETICULUM INVOLVEMENT IN DRUG-INDUCED GINGIVAL OVERGROWTH
ANCUTA GORIUC 1#, IONUT LUCHIAN 2*, ALEXANDRA JITAREANU 3#, LILIANA FOIA 1, MARIA BOGDAN 4, DANA BUDALA 5, DIANA TATARCIUC 6, IOANA MARTU 7
1Department of Biochemistry, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași,
Romania
2Department of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași, Romania
3Department of Toxicology, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași,
Romania
4Department of Pharmacology, University of Medicine and Pharmacy, Craiova, Romania
5Department of Proshodontics, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași, Romania
6Department of Internal Medicine, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115,
Iași, Romania
7Department of Dental Technology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115, Iași, Romania -
EVALUATION OF PHARMACEUTICAL POTENTIAL AND PHYTOCHEMICAL ANALYSIS OF SELECTED TRADITIONAL LICHEN SPECIES
ISA TAS 1,2, ARZU BIRINCI YILDIRIM 3, ERVA OZKAN 1,4, GULSAH COBANOGLU OZYIGITOGLU 5, MUHSINE Z. YAVUZ 6, ARZU UCAR TURKER 1*
1Department of Biology, Faculty of Arts and Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkey
2Korean Lichen Research Institute, Sunchon National University, Sunchon, Republic of Korea
3Department of Field Crops, Faculty of Agriculture and Natural Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkey
4College of Pharmacy, Chonnam National University, Gwangju, Republic of Korea
5Department of Biology, Faculty of Arts and Sciences, Marmara University, Istanbul, Turkey
6Department of Pharmacology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey -
LC-MS/MS USE FOR TESTING PESTICIDES IN CANNABINOID-CONTAINING PRODUCTS
NICOLETA MIRELA BLEBEA 1,2#, GABRIEL HANCU 3#, TEODOR COSTACHE 4, ANNE-MARIE CIOBANU 2*, ANCA NICOARĂ 2#, OANA KARAMPELAS 2, SIMONA NEGREȘ 2
¹“Ovidius” University of Constanța, Faculty of Pharmacy, 6 Căpitan Aviator Al Șerbănescu Street, 900470, Constanța,
Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
3“George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Faculty of Pharmacy, 38 Gheorghe Marinescu Street, 540142, Târgu Mureș, Romania
4Scient Research Center for Instrumental Analysis, Tâncăbești, 1 Petre Ispirescu Street, 077167, Tâncăbești, Ilfov, Romania -
NEWLY SYNTHESIZED AMANTАDINE DERIVATIVE: SAFETY AND NEUROPHARMACOLOGICAL ACTIVITY
IVANKA STANKOVA 1*, MARIA LAZAROVA 2, RADOSLAV CHAYROV 1, ANDREI POPATANASOV 2, LYUBKA TANCHEVA 2, RENI KALFIN 2
1Department of Chemistry, “Neofit Rilski” South-West University, 66 Ivan Michailov Street, 2700 Blagoevgrad, Bulgaria 2Institute of Neurobiology, Bulgarian Academy of Sciences, 23 Acad. G. Bonchev Street, 1113 Sofia, Bulgaria
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CLINICAL ASSESSMENT OF THE THERAPEUTIC OPTIONS FOR ALOPECIA TREATMENT
ANDREI MARIN 1#, SABINA-ELIZA BĂLOI 2*, DANIEL ION 3,7#, CĂTĂLINA-LILIANA
ANDREI 4,7#, SILVIU ADRIAN MARINESCU 5,7, GEORGE TRAIAN ALEXANDRU BURCEADRAGOMIROIU 6,7, CARMEN GIUGLEA 1,71Plastic Surgery Department, “Sf. Ioan” Hospital, 042122, Bucharest, Romania
2Aesthetic&Cosmetic Surgery Center, 011203, Bucharest, Romania
3Surgery III Department, Bucharest Emergency University Hospital, 050098, Bucharest, Romania
4Cardiology and Thoracic Pathology Department, “Bagdasar Arseni” Hospital, 041915, Bucharest, Romania
5Plastic Surgery Department, “Bagdasar Arseni” Hospital, 041915, Bucharest, Romania 6Drug Control Department, Faculty of Pharmacy, 031215, Bucharest, Romania 7“Carol Davila” University of Medicine and Pharmacy, 020021, Bucharest, Romania -
ANTI-GIARDIA ACTIVITY OF TANACETUM VULGARE FLOWERS EXTRACT ON INFECTED MICE
MARIA LUCIA MUREȘAN 1, ANAMARIA COZMA-PETRUȚ 2*, DANIELA BENEDEC 2#, CORNELIA REVNIC 2, DANIELA HANGANU 2, ELENA DINTE 2, ANAMARIA BALEA 3, ILIOARA ONIGA 2#
1“Lucian Blaga” University, Faculty of Medicine, 2A Lucian Blaga Street, 550169, Sibiu, Romania
2“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, 8 V. Babeș Street, 400010, Cluj-Napoca, Romania
3University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, 3-5 Calea Mănăștur Street, 400372, Cluj-Napoca, Romania -
THE CLINICAL EFFICACY AND SAFETY OF SOMATOSTATIN AND THROMBIN COMBINED WITH OMEPRAZOLE FOR THE TREATMENT OF ACUTE UPPER GASTROINTESTINAL BLEEDING
HUI DONG *, FENG-JIE LI, AI-CHUN JIN
Department of Emergency Internal Medicine, Luhe Hospital of Capital Medical University, Beijing 101149, China
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EFFICACY EVALUATION OF THE ASSOCIATION OF SOME VEGETAL EXTRACTS IN PATIENTS SUFFERING FROM TRAUMATIC BRAIN INJURY. PILOT STUDY (II)
CONSTANTIN SORIN GODEANU 1, DOINA MARIN 1, LUMINIȚA STĂNCIULESCU 1, DANIELA GANE 1, ANDREI VĂLEANU 2*, MANUELA GHICA 2, DUMITRU LUPULIASA 2, CERASELA ELENA GÎRD 2
1Department of Anaesthesia and Intensive Care Unit, “Floreasca” Emergency Clinical Hospital, 014461, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 020956 Bucharest, Romania -
DETERMINATION OF POSTHARVEST QUALITY OF PORANG (AMORPHOPHALLUS MUELLERI BLUME) TUBERS BASED ON THE DYNAMICS OF WEIGHT LOSS, WATER CONTENT AND CARBOHYDRATE COMPONENTS FOR THE PHARMACEUTICAL INDUSTRY
DWI GUSMALAWATI 1,2,3, ESTRI LARAS ARUMINGTYAS 2,3, RETNO MASTUTI 2, RODIYATI AZRIANINGSIH 2,3*
1Biology Department, Faculty of Mathematics and Natural Sciences, Tanjungpura University, Jalan A. Yani, Pontianak 78124, Indonesia
2Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jalan Veteran, Malang 65145, Indonesia
3Porang Research Center (PRC) Brawijaya University, Jalan Veteran, Malang 65145, Indonesia -
EVALUATION OF ENDOTOXEMIA, SOLUBLE CD14 AND IL-1Β IN DOGS WITH INTESTINAL DYSBIOSIS THAT WERE TREATED WITH PROBIOTICS: A PROSPECTIVE STUDY
MARIA-CĂTĂLINA MATEI 1, SANDA ANDREI 1, VICTORIA BUZA 1, MIHAI CERNEA 1*, DARIA ANTONIA DUMITRAȘ 1, DANIELA NEAGU 1, HORAȚIU RAFA 1, CRISTIAN PAUL POPOVICI 1, RALUCA POP 2, ADRIAN CĂTINEAN 2, EUGEN ȘTEFĂNUȚ 3, LAURA CRISTINA ȘTEFĂNUȚ 1
1Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Romania
2“Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania 3EST Research, Bucharest, Romania -
IN VITRO PHARMACOLOGICAL EVALUATION OF GALIUM ELEGANS: PHYTOCHEMICAL, ANTIOXIDANT, BIOFILM INHIBITION AND CYTOTOXICITY POTENTIAL
TAHIR ZAMAN 1, MUHAMMAD IRSHAD 2, MUHAMMD FARAZ KHAN 3, ANSAR MEHMOOD 3*, IMTIAZ HUSSAIN 4, MAJID MAHMOOD 5
1Department of Chemistry, University of Poonch Rawalakot, 12350, Azad Jammu and Kashmir, Pakistan
2Department of Chemistry, University of Kotli Azad Jammu and Kashmir, 11100, Azad Jammu and Kashmir, Pakistan
3Department of Botany, University of Poonch Rawalakot, 12350, Azad Jammu and Kashmir, Pakistan
4Department of Food Science and Technology, University of Poonch Rawalakot (UPR), 12350, Azad Kashmir, Pakistan 5Department of Zoology, University of Poonch Rawalakot, 12350, Azad Jammu and Kashmir, Pakistan -
GASTROPROTECTIVE EFFECTS OF VITEX DONIANA LEAF FRACTIONS AGAINST ACETIC ACID INDUCED GASTRIC ULCER MODEL IN ALBINO RATS
OKECHUKWU STEVEN ONWUKWE *, NKIRUKA CHINONYELUM AZUBUIKE, PETER UWADIEGWU ACHUKWU
Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, University of Nigeria Enugu Campus, Nigeria
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SPECTROPHOTOMETRIC EVALUATION OF FLAVONOIDS, PHENOLCARBOXYLIC ACIDS AND TOTAL PHENOLIC CONTENTS OF SEVERAL INDIGENOUS HERBAL PRODUCTS WITH POTENTIAL HEPATOPROTECTIVE EFFECT
LILIANA COSTEA #, MANUELA GHICA *, TEODORA COSTEA #, CERASELA ELENA GÎRD
“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
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SOCIO-DEMOGRAPHIC PROFILE OF THE ROMANIAN PATIENT REGARDING THE FACTORS INFLUENCING THE CHOICE OF A PHARMACY USING LOGISTIC REGRESSION AND FACTOR ANALYSIS
MARIUS CĂLIN CHERECHEȘ 1*, CRISTIAN POPA 2, CORNELIU FLORIN BUICU 3
1University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade”, 38 Gheorghe Marinescu Street, Târgu Mureș, Romania
2Faculty of European Studies, Babeș-Bolyai University, 1 Emmanuel de Martonne Street, Cluj-Napoca, Romania -
PREGABALIN CONSUMPTION IN TURKEY: WAS IT AN ABUSE?
EMRAH BILGENER 1*, BURAK GÜMÜŞ 2
1Department of Health Care Management, Faculty of Health Sciences, Hitit University, Çorum, Turkey 2Department of Forensic Medicine, Faculty of Medicine, Hitit University, Çorum, Turkey