Current Issue
Volume 69 | Number 3 Year 2021
Download this issue’s covers and announcements.
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DEVELOPMENTS IN PROSTATE CANCER THERAPY: FROM THE ANDROGEN RECEPTOR TO ANTIANDROGENS AND BEYOND
IULIAN PRUTIANU 1, IRINA DRAGA CĂRUNTU 1*, MARIANA BIANCA MANOLE 1, SIMONA
ELIZA GIUȘCĂ 1, BIANCA PROFIRE 1, ANDREI DANIEL TIMOFTE 1, LENUȚA PROFIRE 2,
BOGDAN GAFTON 31Department Morpho-Functional Sciences I - Histology, Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania
2Department Pharmaceutical Sciences I - Pharmaceutical Chemistry, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania
3Department Medical III - Medical Oncology - Radiotherapy, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania -
RHO-KINASE INHIBITORS – A NEW BROAD-SPECTRUM TREATMENT IN OPHTHALMIC DISEASES. A REVIEW
RALUCA IANCU 1,2#, RUXANDRA PIRVULESCU 1,2*, SANZIANA ISTRATE 1,2#, ALINA POPA CHERECHEANU 1,2, GEORGE IANCU 1,3, MARIAN BURCEA 1,4
1“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 040292, Bucharest, Romania
2Emergency University Hospital Bucharest, 169 Independence Street, 050098, Bucharest, Romania
3“Filantropia” Clinical Hospital Bucharest, 11-13 Ion Mihalache Street, 011171, Bucharest, Romania
4Emergency Ophthalmology Hospital Bucharest, 1 Lahovari Square, 010464, Bucharest, Romania -
PLATINUM HYPERSENSITIVITY REACTIONS, A FOCUS ON DESENSITISATION
ANDREI HAVASI 1#, CRISTINA CRIȘAN 2, ANA TEODORA HEPUTIU-PATER 4, OVIDIU-
VASILE BOCHIS 2, CALIN CAINAP 2,3#, OVIDIU CRISAN 7*, OVIDIU BALACESCU 2#,
LOREDANA BALACESCU 2, SIMONA CAINAP 5,61Department of Research, Development and Innovation, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-
Napoca, Romania
2“Prof. Dr. Ion Chiricuță”, Institute of Oncology, Cluj-Napoca 400015, Romania
3Department of Oncology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
4“Dr. Gavril Curteanu” Municipal Clinical Hospital, Oradea, Romania
5Department of Mother and Child “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
6Department of Pediatrics, Emergency Pediatric Clinical Hospital, Cluj Napoca, Romania
7Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania -
EVALUATION OF DOCETAXEL USE IN NON-SMALL CELL LUNG CANCER: REAL-WORLD HEALTH OUTCOMES
MACARENA MERINO ALMAZAN 1*, JUAN FRANCISCO MARIN POZO 1, JUAN MANUEL
DUARTE PEREZ 21Hospital Pharmacy Department, Servicio de Farmacia Hospitalaria, Hospital Universitario de Jaén, Avda Ejército Español, 10, 23007 Jaén, Spain
2Pharmacology Department, Faculty of Pharmacy, University of Granada, Granada, Spain -
STRUCTURAL AND THERMAL ANALYSIS OF CANNABIDIOL ORODISPERSIBLE FORMULATIONS
ROBERT-ALEXANDRU VLAD 1, TAMÁS SOVÁNY 2, KATALIN KRISTÓ 2, YOUSIF H-E.Y.
IBRAHIM 2, ADRIANA CIURBA 1, ZOLTÁN AIGNER 2, DANIELA LUCIA MUNTEAN 3*, GÉZA REGDON JR. 21“George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Faculty of Pharmacy, Pharmaceutical Technology and Cosmetology Department, 38 Gheorghe Marinescu Street, 540142, Târgu Mureș, Romania
2University of Szeged, Institute of Pharmaceutical Technology and Regulatory Affairs, 6 Eötvös Street, 6720, Szeged, Hungary
3“George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Faculty of Pharmacy,
Analytical Chemistry and Drug Analysis Department, 38 Gheorghe Marinescu Street, 540142, Târgu Mureș, Romania -
PRELIMINARY STUDY REGARDING THE FORMULATION AND PHYSICAL EVALUATION OF SOME BIOCOMPATIBLE, OIL IN WATER MICROEMULSIONS WITH SALICYLIC ACID FOR DERMATOLOGIC USE
MARIA CRISTINA ANICESCU, CRISTINA ELENA DINU-PÎRVU, MIHAELA VIOLETA GHICA *,
MARINA THEODORA TALIANU, LĂCRĂMIOARA POPADepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
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SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY EVALUATION OF Ni(II), Cu(II) AND Zn(II) COMPLEXES WITH DEOXYCHOLATE LIGAND
DANIELA C. CULITA 1#*, LORA DYAKOVA 2#, GABRIELA MARINESCU 1, TANYA ZHIVKOVA 3,
MILENA GEORGIEVA 4, BELA VASILEVA 4, ROSSEN SPASOV 5, GEORGE MILOSHEV 4,
RENI KALFIN 2, MELITA VIDAKOVIC 6, OVIDIU OPREA 7, RADOSTINA ALEXANDROVA 31“Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, Bucharest, Romania
2Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
3Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
4“Acad. Roumen Tsanev” Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria
5Faculty of Medicine, “St. Kliment Ohridski” Sofia University, Sofia, Bulgaria
6Institute for Biological Research, Belgrade, Serbia
7Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science, Bucharest, Romania -
EVALUATION OF THE CHEMICAL COMPOSITION OF AJUGA CHAMAEPITYS (L.) SCHREB. FROM THE SPONTANEOUS FLORA OF ROMANIA
ELIS IONUS 1#, LAURA ADRIANA BUCUR 2*, CARMEN ELENA LUPU 3#, CERASELA ELENA GȊRD 1
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacognosy, Phytochemistry and Phytotherapy, 6 Traian Vuia Street, District 2, 020956, Bucharest, Romania
2“Ovidius” University of Constanţa, Faculty of Pharmacy, Department of Pharmacognosy, Phytochemistry and Phytotherapy, 6 Căpitan Aviator Al. Șerbănescu Street, Campus, Corp C, Constanţa, Romania
3“Ovidius” University of Constanţa, Faculty of Pharmacy, Department of Mathematics and Informatics, 6 Căpitan Aviator Al. Șerbănescu Street, Campus, Corp C, Constanţa, Romania -
THE EFFECT OF METHYLPHENIDATE HYDROCHLORIDE COMBINED WITH PLATYCLADI SEED EXTRACT ON ATTENTION DEFICIT HYPERACTIVITY DISORDER IN A MURINE MODEL
JINHUA ZHAO 1,2, JIHONG TANG 1*, XIAOYAN SHI 1
1Department of Neurology, Children’s Hospital Affiliated to Soochow University, Suzhou, 215025, Jiangsu, China
2Department of Pediatrics, Nantong First People’s Hospital, Nantong, 226001, Jiangsu, China -
NEW INSIGHTS ON SOME 6-CHLORO-9H-CARBAZOL DERIVATIVES CONCERNING THEIR IN VITRO ANTIOXIDANT CAPACITY AND IN VIVO CYTOTOXICITY
ALEXANDRA TEODORA BORDEI (TELEHOIU) 1, TEODORA COSTEA 1*, CARMEN LIMBAN 1,
DIANA CAMELIA NUȚĂ 1, CERASELA ELENA GÎRD 1, IRINA ZARAFU 2, TEODORA DALILA BALACI 1, OANA KARAMPELAS 1, ROBERT VIOREL ANCUCEANU 11“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest,
Romania
2University of Bucharest, Faculty of Chemistry, 4-12 Regina Elisabeta Boulevard, 030018 Bucharest, Romania -
APPLYING THE PRINCIPLES OF QUALITY BY DESIGN (QbD) COUPLED WITH MULTIVARIATE DATA ANALYSIS (MVDA) IN ESTABLISHING THE IMPACT OF RAW MATERIAL VARIABILITY FOR EXTENDED RELEASE TABLETS
KINGA ILYÉS 1, TIBOR CASIAN 1*, DANA HALES 1, GHEORGHE BORODI 2, LUCIA RUS 3,
RAREȘ ȘTIUFIUC 4,5, IOAN TOMUȚĂ 11Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania
3Department of Drug Analysis, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, ClujNapoca, Romania
4Department of Pharmaceutical Biophysics, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
5MedFuture Research Centre for Advanced Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, ClujNapoca, Romania -
DESCRIPTIVE ANALYSIS OF REAL-WORLD MEDICATION PATTERNS AND ONE-YEAR OUTCOMES OF ACUTE CORONARY SYNDROME PATIENTS WITH METABOLIC SYNDROME IN A TERTIARY CARE HOSPITAL
PRISCILLA PAȘC 1,2, DANIELA ELISABETA BERDEA 1, LUCIANA DOBJANSCHI 1*,
CLAUDIA TEODORA JUDEA-PUSTA 1, MIRCEA IOACHIM POPESCU 1,21Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania 2Emergency County Clinical Hospital of Oradea, Oradea, Romania
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A NEW FORMULATION OF CINNAMON OIL AND CHITOSAN DEPOLYMERIZED AGAINST OPPORTUNISTIC MICROORGANISMS DURING WOUND HEALING
MARÍA LUISA DEL PRADO-AUDELO 1,2, ADRIANA ESTELA HERNÁNDEZ-TENORIO 1,
MAYKEL GONZÁLEZ-TORRES 3, JONATHAN J. MAGAÑA 4, ROBERTO SÁNCHEZSÁNCHEZ 5, MARÍA DEL PILAR GRANADA-MACÍAS 6, SILVESTRE ORTEGA-PEÑA 7,
HERNÁN CORTES 4, GERARDO LEYVA-GÓMEZ 1*1Department of Pharmacy, Faculty of Chemistry, National Autonomous University of Mexico, Ciudad Universitaria, Circuito Exterior S/N, Del. Coyoacán, Mexico City, Mexico
2Graduate Laboratory in Pharmaceutical Technology, FES-Cuautitlán, National Autonomous University of Mexico, Cuautitlán Izcalli, Mexico
3CONACyT-Biotechnology Laboratory, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City, Mexico
4Genomic Medicine Laboratory, Department of Genetics, National Center for Research and Attention to Burns (CENIAQ),
National Institute of Rehabilitation-Luis Guillermo Ibarra Ibarra (INR-LGII), Mexico City, Mexico
5Tissue Engineering Unit Cell Therapy and Regenerative Medicine, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra (INR-LGII), Mexico City, Mexico
6Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Ciudad Universitaria, Circuito
Exterior S/N, Del. Coyoacán, Mexico City, Mexico
7Laboratory of Infectology, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Mexico City, Mexico -
ESTIMATION OF QUINOLONES, CEFTIOFUR AND THIAMPHENICOL RESIDUES LEVELS IN HONEY
IONELA DANIELA MORARIU 1#, LILIANA AVASILCĂI 1, MĂDĂLINA VIERIU 1#, IONUȚ
IULIAN LUNGU 1, BRANCO MORARIU 1#, SILVIA ROBU 2, DANA TIUTUNARU 2, OANA
CIOANCĂ 1*, MONICA HĂNCIANU 1“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, 16 Universității Street, 700115, Iași,
Romania
2Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 35 Al. I. Cuza Street, 800010 Galați, Romania -
SYNTHESIS, CHARACTERIZATION AND CYTOTOXICITY ASSESSMENT OF NEW 4-BENZYL-1,3-OXAZOLE DERIVATIVES INCORPORATING 4-[(4-BROMOPHENYL)SULFONYL]PHENYL FRAGMENT
THEODORA VENERA APOSTOL 1*, CONSTANTIN DRĂGHICI 2, LAURA ILEANA SOCEA 1,
OCTAVIAN TUDOREL OLARU 3, GABRIEL ȘARAMET 4, MĂDĂLINA HRUBARU 2,
ȘTEFANIA FELICIA BĂRBUCEANU 11“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Organic Chemistry Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
2“Costin D. Nenițescu” Institute of Organic Chemistry, Romanian Academy, 202B Splaiul Independenței Street, 060023, Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Botany and Cell Biology Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
4“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Technology and
Biopharmacy Department, 6 Traian Vuia Street, 020956, Bucharest, Romania -
EPIDEMIOLOGY AND ANTIBIOTIC RESISTANCE PROFILE OF BACTERIAL UROPATHOGENS IN MALE PATIENTS: A 10-YEAR RETROSPECTIVE STUDY
MÁRIÓ GAJDÁCS 1*, MARIANNA ÁBRÓK 2, ANDREA LÁZÁR 2, KATALIN BURIÁN 2,3
1Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6, 6720 Szeged, Hungary
2Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Semmelweis utca 6, 6725 Szeged, Hungary 3Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, 6720 Szeged, Hungary -
EVALUATION OF COMBINED PHARMACOLOGIC TREATMENT INVOLVING TADALAFIL AND ALPROSTADIL INTRAURETHRAL GEL FOR PENILE REHABILITATION AFTER RADICAL PROSTATECTOMY
CATALIN BELINSKI 1, ALEXANDRU AUNGURENCI 1*, ANDREI RADULESCU 1, OVIDIU
BRATU 2, DAN MISCHIANU 21“Professor Dr. D. Gerota” Urology Department, Emergency Hospital, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, “Dr. Carol Davila” Central Military Emergency University Hospital, Bucharest, Romania -
THE EFFECT OF SOMATOSTATIN COMBINED WITH OMEPRAZOLE ON PATIENTS WITH SEVERE ACUTE PANCREATITIS
JIANHUA HONG 1#, JINYAN MI 2#*
1Department of Digestive Internal Medicine, Tonglu First people's Hospital, Tonglu, Hangzhou, 311500, China
2Orthopedic Aftercare Comprehensive Ward, Tonglu Hospital of Traditional Chinese Medicine, Tonglu, Hangzhou, 311500, China -
THE ROLE OF SERUM IONS DEFICIENCIES IN THE PATHOGENIC MECHANISMS OF ONCOLOGICAL DEPRESSION: PSYCHO- PHARMACOLOGICAL PARTICULARITIES
ADELA MAGDALENA CIOBANU 1,2#, MARA JIDVEIAN POPESCU 3*, MIHNEA COSTIN
MANEA 2,4#, DOINA DRĂGĂNESCU 5#, DUMITRU LUPULIASA 6, DRAGOȘ MARINESCU 7, PUIU OLIVIAN STOVICEK 81“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Neuroscience Department, Discipline of
Psychiatry, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
2“Prof dr. Alexandru Obregia” Clinical Psychiatric Hospital, Department of Psychiatry, 10th Berceni Road, 041914,
Bucharest, Romania
3CF2 Clinical Hospital, Oncology Department, 63 Mărăști Street, 012244, Bucharest, Romania
4“Carol Davila” University of Medicine and Pharmacy, Faculty of Dental Medicine, Discipline of Psychiatry and Psychology, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
5“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Physics and
Informatics, 6 Traian Vuia Street, 020956, Bucharest, Romania
6“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Technology and
Biopharmaceutics, 6 Traian Vuia Street, 020956, Bucharest, Romania
7Academy of Medical Sciences of Romania, University of Medicine and Pharmacy of Craiova Brunch, 2 Petru Rareș Street, 200349, Craiova, Romania
8“Titu Maiorescu” University Bucharest, Faculty of Nursing, Department of Pharmacology, Târgu Jiu Subsidiary, 100
Ecaterina Teodoroiu Avenue, 210106, Gorj County, Romania -
DEVELOPMENT OF A TECHNIQUE FOR DETERMINING CADMIUM, LEAD, ARSENIC WITH THE ETAAS METHOD IN MEDICINAL PLANT RAW MATERIALS
ALEXANDER NIKULIN, OLGA POTANINA *, MOHSEN ALYUSSEF, VASILIY VASIL’EV,
RIMMA ABRAMOVICH, OLEG NOVIKOV, NIKOLAY BOYKO, ARKADIY KHROMOV,
EVGENIY PLATONOVPeoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
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STATINS AND THE RISK FOR CORONARY IN-STENT RESTENOSIS IN DIABETIC PATIENTS
DANIEL NIŢĂ 1#, MIHAELA IONESCU 2, LAURA MAZILU 2, ANDRA IULIA SUCEVEANU 2, ALICE MUNTEANU 1, PARIS IONESCU 2, LILIANA ANA TUŢĂ 2*, FLORIN BUICU ³#, IRINEL RALUCA PAREPA 2
1Army’s Centre for Cardiovascular Diseases, Bucharest, Romania
2“Ovidius” University of Constanța, Faculty of General Medicine, Constanța, Romania
3“George Emil Palade” University of Medicine, Pharmacy, Science and Technology, Târgu-Mureș, Romania -
COMPATIBILITY STUDIES OF SELECTED MUCOLYTIC DRUGS WITH EXCIPIENTS USED IN SOLID DOSAGE FORMS: THERMOGRAVIMETRY ANALYSIS
PAWEŁ RAMOS *
Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Jedności 8, 41-200 Sosnowiec, Poland
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CINNAMIC ACID AND ITS DERIVATIVES IN THE HERBAL MIXTURES AND THEIR ANTIDIABETIC ACTIVITY
ALONA SAVYCH 1*, SVITLANA MARCHYSHYN 1#, MARIIA KYRYLIV 2#, IRYNA BEKUS 2#
1Department of Pharmacognosy with Medical Botany, I. Horbachevsky Ternopil National Medical University, Ukraine 2Department of General Chemistry, I. Horbachevsky Ternopil National Medical University, Ukraine
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KNOWLEDGE, OPINION AND ATTITUDES TOWARDS ADVERSE DRUG REACTIONS REPORTING AMONG PHARMACY STUDENTS IN ROMANIA
ANDREEA FARCAȘ 1#, CAMELIA BUCȘA 1*, ANDA CRIȘAN 1#, IRINA CAZACU 1, DANIEL
LEUCUȚA 2#, CRISTINA MOGOȘAN 11Drug Information Research Center, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Medical Informatics and Biostatistics Department, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania -
CONSEQUENCES OF THE PRICE DECREASE FOR PRESCRIPTION (RX) DRUGS 2015 – 2019
PETRU CRĂCIUN 1#, MARIAN PANĂ 1*, ADRIANA-ELENA TĂEREL 2#, MANUELA GHICA 3#, DUMITRU LUPULIASA 1
1Pharmaceutical Technology and Biopharmacy Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2Department of Pharmaceutical Management and Marketing, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3Department of Biostatistics, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania