Romanian Society of Pharmaceutical Sciences
 

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NEW ACYL-OXIMINE DERIVATIVES SYNTHESIS AND THEIR PRELIMINARY PHARMACOTOXICOLOGICAL INVESTIGATION

DANA MIHAELA CIOROIANU1, CORNEL CHIRIŢĂ2*, CARMEN LIMBAN1, ALEXANDRU VASILE MISSIR1, ILEANA CORNELIA CHIRIŢĂ1, MIRON TEODOR CĂPROIU3, SIMONA NEGREŞ2, FLORIANA ELVIRA IONICĂ4, DIANA CAMELIA NUŢĂ1

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 6 Traian Vuia Street, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, 6 Traian Vuia Street, Bucharest, Romania
3.The Organic Chemistry Centre of Romanian Academy “C. D. Neniţescu”, 202B Splaiul Independenţei, Bucharest, Romania
4.University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology, 2-4 Petru Rareș Street, Craiova, Romania

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The present study represents a continuation of previous research with the aim to obtain and to physicochemical characterize some new compounds having tricyclic structure. We performed also a preliminary pharmacotoxicological investigation in order to evaluate the compounds systemic toxicity. The structure of these substances, which are O-acyl-oximine derivatives with 5H-dibenzo[a,d]cycloheptatrienic structure, was confirmed by elemental analysis, IR and nuclear magnetic resonance (NMR) NMR-spectrometry.