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THE ELABORATION OF NOVEL ANALYTICAL METHODS FOR CLEMASTINE AND TIMOLOL

ALEXANDRA FILARETA NEAGU ^*#, IOANA CLEMENTINA CONSTANTINESCU ^#

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Based on the reactions between clemastine/timolol and the silicotungstic acid, H4[SiW12O40], combinations by ionic association, hardly soluble in water, having the following formula: [CL]4[SiW12O40]·2H2O and [TM]4[SiW12O40]·2H2O are obtained. The confirmation of the structures of the new complexes and their setting conditions for processing were performed in previous work. The obtained data were used for the development of new methods for the assay of the two studied drugs. The established methods are accurate and reproducible.