Romanian Society of Pharmaceutical Sciences
 

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NEW SYNTHESIS IN THE N-[4-[(PHENYLCARBAMOYL)AMINO]- PHENYL]BENZENESULFONAMIDE DERIVATIVES SERIES. NOTE 1

IOANA DANA ROTARU (ENACHE)1, DIANA CAMELIA NUȚĂ1*, ILEANA CORNELIA CHIRIŢĂ1, MIRON TEODOR CĂPROIU2, CARMEN LIMBAN1, ALEXANDRU VASILE MISSIR1, CORNEL CHIRIȚĂ1

1.”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, Romania, 6 Traian Vuia St., Bucharest, 020956, Romania
2.”C. D. Neniţescu” The Organic Chemistry Centre of Romanian Academy, 202B Splaiul Independenţei, Bucharest, Romania

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A series of N-[4-[(phenylcarbamoyl)amino]phenyl]benzenesulfonamide derivatives was prepared by Curtius degradation of corresponding azide, followed by condensation with primary aromatic amines. Such compounds may have different pharmacological properties, such as antibacterial, antifungal, hypoglicemic, diuretic. The structures of these substances were confirmed by elemental analysis, IR and NMR – spectrometry.