Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS, CHARACTERIZATION AND MICROBIOLOGICAL ACTIVITY EVALUATION OF TWO SILVER COMPLEXES WITH NORFLOXACIN

AURA RUSU1, GABRIEL HANCU1*, GERGŐ TÓTH2, FELICIA TOMA3, ANCA DELIA MARE3, ADRIAN MAN3, BRUNO ŞTEFAN VELESCU4, VALENTINA UIVAROȘI5

1.University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Pharmacy, Pharmaceutical Chemistry Department, 38 Gheorghe Marinescu Street, Tîrgu Mureș, 540139, Romania
2.Semmelweis University, Pharmaceutical Chemistry Department, 9 Hőgyes Endre Street, Budapest, H-1092, Hungary
3.University of Medicine and Pharmacy of Tîrgu Mureş, Faculty of Medicine, Microbiology, Virology, and Parasitology Department, 38 Gheorghe Marinescu Street, Tîrgu Mureș, 540139, Romania
4.”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacology and Clinical Pharmacy Department, 6 Traian Vuia Street, 2 District, Bucharest, 020956, Romania
5.”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, General and Inorganic Chemistry Department, 6 Traian Vuia Street, 2 District, Bucharest, 020956, Romania

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Silver complexes of norfloxacin (NOR) are interesting for therapeutic purposes due to possible synergistic bactericidal and antifungal potential provided by the metal and fluoroquinolones (FQ). In order to obtain new compounds with superior antibacterial and antifungal properties, we synthesized two silver complexes of NOR. A multi-analytical approach was carried out by using elemental analysis (C, H, N), conductivity measurement, differential scanning calorimetry and spectroscopic methods (FT-IR, 1H-NMR, UV-VIS and PL). The screening of antibacterial activity and antifungal of the complexes was performed by determination of minimal inhibitory concentration (MIC) through microtiter broth dilution method.