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SCREENING OF THIOALKANOIC SUBSTITUTED 1,4- NAPHTHOQUINONES AS POTENT ANTIMICROBIAL AGENTS

GABRIELA RĂU ^1#, FLAVIA MARIA CREŢU ^1#, ANCA BERBECARU-IOVAN ^1#*, CAMELIA ELENA STĂNCIULESCU¹, ANA MARINA ANDREI¹, GEORGE DAN MOGOŞANU¹, MARIA BĂLĂŞOIU^1,2, ILEANA MONICA BANIŢĂ^1,3, CĂTĂLINA GABRIELA PISOSCHI^1,2

1.University of Medicine and Pharmacy, 2-4 Petru Rareş, 200349, Craiova, Dolj, Romania
2.Clinical Laboratory, Emergency Clinical County Hospital, 1 Tabaci, 200642, Craiova, Dolj, Romania
3.Clinical Laboratory, Clinical Hospital of Neuropsychiatry, 99 Calea București, 200473, Craiova, Dolj, Romania

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In the present study, there are described the synthesis and evaluation of physico-chemical properties and antimicrobial activity of some hetero-1,4-naphthoquinones containing thiol groups substituted with alkanoic acids. The synthesis of the new derivatives consists in a condensation between 2,3-dichloronaphthalen-1,4-dione and some thioalkanoic acids. The structures of the pure products were characterized by spectroscopic methods. The antimicrobial activity was tested on Grampositive and Gram-negative bacteria and the antifungal activity on Candida albicans using the disk diffusion method. The compounds tested proved activity against Candida albicans and Gram-positive bacteria.

« Back to Farmacia Journal 6/2016

SCREENING OF THIOALKANOIC SUBSTITUTED 1,4- NAPHTHOQUINONES AS POTENT ANTIMICROBIAL AGENTS

GABRIELA RĂU 1#, FLAVIA MARIA CREŢU 1#, ANCA BERBECARU-IOVAN 1#*, CAMELIA ELENA STĂNCIULESCU1, ANA MARINA ANDREI1, GEORGE DAN MOGOŞANU1, MARIA BĂLĂŞOIU1,2, ILEANA MONICA BANIŢĂ1,3, CĂTĂLINA GABRIELA PISOSCHI1,2

GABRIELA RĂU ^1#, FLAVIA MARIA CREŢU ^1#, ANCA BERBECARU-IOVAN ^1#*, CAMELIA ELENA STĂNCIULESCU¹, ANA MARINA ANDREI¹, GEORGE DAN MOGOŞANU¹, MARIA BĂLĂŞOIU^1,2, ILEANA MONICA BANIŢĂ^1,3, CĂTĂLINA GABRIELA PISOSCHI^1,2