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SCREENING OF THIOALKANOIC SUBSTITUTED 1,4-NAPHTHOQUINONES AS POTENT ANTIMICROBIAL AGENTS

GABRIELA RĂU ^1#, FLAVIA MARIA CREŢU ^1#, ANCA BERBECARU-IOVAN ^1#*, CAMELIA ELENA STĂNCIULESCU¹, ANA MARINA ANDREI¹, GEORGE DAN MOGOŞANU¹, MARIA BĂLĂŞOIU^1,2, ILEANA MONICA BANIŢĂ^1,3, CĂTĂLINA GABRIELA PISOSCHI^1,2

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In the present study, there are described the synthesis and evaluation of physico-chemical properties and antimicrobial activity of some hetero-1,4-naphthoquinones containing thiol groups substituted with alkanoic acids. The synthesis of the new derivatives consists in a condensation between 2,3-dichloronaphthalen-1,4-dione and some thioalkanoic acids. The structures of the pure products were characterized by spectroscopic methods. The antimicrobial activity was tested on Grampositive and Gram-negative bacteria and the antifungal activity on Candida albicans using the disk diffusion method. The compounds tested proved activity against Candida albicans and Gram-positive bacteria.