Farmacia Journal 4/2022
Volume 70 | Number 4 | Year 2022
Download this issue’s covers, and announcements.
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MINI-REVIEW ON THE IMPLICATIONS OF GENE POLYMORPHISM IN THE METABOLISM OF XENOBIOTICS
ALINA-COSTINA LUCA 1, ALIN CIOBICA 2, WALTHER BILD 1,5, ALEXANDRINA-STEFANIA CURPAN 3*, ELENA EMANUELA BRAHA 4
1“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, 700115, Iași, Romania
2 “Alexandru Ioan Cuza” University of Iasi, Department of Research, Faculty of Biology, 700505, Iași, Romania
3 “Alexandru Ioan Cuza” University of Iasi, Department of Biology, Faculty of Biology, 700505, Iași, Romania
4 “C.I. Parhon” National Institute of Endocrinology, 011863, Bucharest, Romania
5 Center of Biomedical Research of the Romanian Academy, 700481, Iași Romania -
ANALGESIC ED50 DICLOFENAC-EUGENOL COMBINATION EFFECT ON PROINFLAMMATORY CYTOKINES – IL-1β, IL-6, TNFα AND MAPKs – IN RAT MUSCLE
OLGA EDITH GONZÁLEZ-LUGO 1, DIANA MARÍA ESCOBAR-GARCÍA 2, AMAURY DE
JESÚS POZOS-GUILLÉN 2, PATRICIA PONCE PEÑA 3, ABELARDO CAMACHO LUIS 4,
MARTHA SOSA-MACÍAS 4, ISMAEL LARES ASEFF 4, AZAHEL RANGEL-LÓPEZ 1, ANGEL
ANTONIO VÉRTIZ-HERNÁNDEZ 1*1Region Altiplano Academic Coordination (UASLP), Autonomous University of San Luis Potosí, 78700, San Luis Potosí, Mexico
2 Basic Science Laboratory, Faculty of Dentistry Autonomous University of San Luis Potosí, 78890, San Luis Potosí, Mexico
3 Faculty of Chemical Sciences, Juarez University of the State of Durango, 34120, Durango, Mexico
4 Interdisciplinary Research Centre for Integral Regional Development, Durango Unit - National Polytechnic Institute (CIIDIR-IPN), 34220, Durango, Mexico -
RECENT ADVANCES IN THE STUDY OF DERIVATIVES OF (EZ)-N’- BENZYLIDENE-(2RS)-2-(6-CHLORO-9H-CARBAZOL-2-YL) PROPANOHYDRAZIDE
ALEXANDRA TEODORA (TELEHOIU) BORDEI 1, CARMEN LIMBAN 1*, DIANA CAMELIA
NUȚĂ 1, IRINA ZARAFU 2, ELEONORA DENES 3, LUMINIȚA MĂRUȚESCU 4,5, MARIANA CARMEN CHIFIRIUC 4,5,6, MARCELA POPA 4,5, CORINA ARAMĂ 11Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania 2Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta, 030018 Bucharest, Romania
3 Supramolecular Organic and Organometallic Chemistry Centre, Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany János, 400028 Cluj-Napoca, Romania
4 Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 91-96 Splaiul Independenței, Bucharest, Romania
5 Research Institute of the University of Bucharest, University of Bucharest, 90 Panduri Road, Bucharest, Romania
6 Academy of Romanian Scientist, 54 Splaiul Independetei, Bucharest, Romania -
QUALITY BY DESIGN APPROACH FOR THE DEVELOPMENT OF SALINOMYCIN AND GEMCITABINE COMBINATION THERAPY LIPOSOMES FOR COLORECTAL CANCER
LUCIA RUXANDRA TEFAS, IOANA TOMA *, IOAN TOMUȚĂ
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 V. Babeș Street, 400012, Cluj-Napoca, Romania
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TWO BIOACTIVE COMPOUNDS, ROSMARINIC ACID AND SINAPIC ACID, DO NOT AFFECT THE DEPLETED GLUTATHIONE LEVEL IN THE LENSES OF TYPE 2 DIABETIC FEMALE RATS
MARIA ZYCH 1*, WERONIKA BORYMSKA 1, KATARZYNA URBISZ 1, MAREK
KOSTRZEWSKI 2, ILONA KACZMARCZYK-ŻEBROWSKA 11Department of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland
2 Society of Silesian Veterinary Polyclinics, Katowice, Poland -
HYDROPHOBICALLY MODIFIED DEXTRAN ESTERS AS POTENTIAL EXTERNAL BIOCIDES
CRISTINA G. TUCHILUS 1, DALILA BELEI 2, ADINA COROABA 3, MARIETA NICHIFOR 4,
MAGDALENA CRISTINA STANCIU 4*1“Grigore T. Popa” University of Medicine and Pharmacy, Department of Microbiology, Faculty of Medicine, 16 University Street, 700115, Iaşi, Romania
2 “Al. I. Cuza” University of Iaşi, Faculty of Chemistry, Department of Organic Chemistry, 11 Carol I Avenue, 700506, Iaşi,
Romania
3 “Petru Poni” Institute of Macromolecular Chemistry, Centre of Advanced Research in Bionanoconjugates and
Biopolymers, 41A Grigore Ghica Voda Alley, Iaşi, 700487, Romania
4 “Petru Poni” Institute of Macromolecular Chemistry, Department of Natural Polymers, Bioactive and Biocompatible Materials, 41 A Grigore Ghica Voda Alley, 700487, Iaşi, Romania -
RISK FACTORS, ORAL ANTICOAGULANTS-BASED THERAPEUTICAL APPROACHES AND COMORBIDITIES IN ATRIAL FIBRILLATION: 4216 PATIENTS FROM A ROMANIAN HOSPITAL
MIRELA MARIOARA TOMA 1, DELIA MIRELA TIT 1,2*, RADU DUMITRU MOLERIU 3, ALEXA
FLORINA BUNGAU 4, CAMELIA CRISTINA DIACONU 5,6, SIMONA GABRIELA BUNGAU 1,21Department of Biomedical Sciences, Doctoral School of the University of Oradea, University of Oradea, Oradea, 410087, Romania
2 Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, 410087, Romania
3 Mathematics Department, Faculty of Mathematics and Computer Science, West University Timișoara, Timișoara, 30022, Romania
4 Medicine Program of Study, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, 410087, Romania
5 Department of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, 050474, Romania 6Clinical Emergency Hospital of Bucharest, Bucharest, 105402, Romania -
MECHANISM OF RITUXIMAB IN THE TREATMENT OF NEUROMYELITIS OPTICA
CHUNHUA YUAN 1, YING LIU 2, YANKUN HAO 3, LEI YAN 4, JUN LIANG 5, HUIPENG JIN 2*
1Department of Neurology, Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang city, 157000, China
2 Ophthalmic Function Room, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang city, 157000, China
3 Department of Medical Function, Mudanjiang Medical University, Mudanjiang city, 157000, China
4 Department of Histology and Embryology, Mudanjiang Medical University, Mudanjiang city, 157000, China
5 Stem Cell Institute, Mudanjiang Medical University, Mudanjiang city, 157000, China -
CHANGES IN BIOCHEMICAL PARAMETERS IN DIABETES AFTER SUCCESSFUL DIRECT-ACTING ANTIVIRAL TREATMENT OF HEPATITIS C VIRUS
MARIAN-SORIN POPESCU 1, DAN-MIHAI FIRU 1, VLAD PĂDUREANU 1, CRISTINA MARIA
MĂRGINEAN 1, DANIEL-CRISTIAN PÎRVU 1, ANDREI OSMAN 2*, RADU MITRUȚ 3, SIMONA
PÂRVU 4, DRAGOȘ NICOLAE MĂRGĂRITESCU 5, DANIELA CĂLINA 6, ANCA OANA
DOCEA 7, PAVEL CĂLIN COBELSCHI 8, PAUL MITRUȚ 11Department of Medical Semiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2 Department of Anatomy and Embryology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 3Department of Cardiology, University and Emergency Hospital, 050098 Bucharest, Romania
4 Department of Hygiene and Medical Ecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest,
Romania
5 Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
6 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
7 Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
8 Department of Medical and Surgical Specialties, Faculty of Medicine, Transylvania University of Brașov, 500019 Brașov, Romania -
COMPARATIVE RESEARCH BETWEEN SOLIFENACINTAMSULOSIN VERSUS TAMSULOSIN ALONE IN EXPULSION OF JUXTAVESICAL URETERAL STONES
CĂTĂLIN PRICOP 1,2, VIOREL JINGA 3,4, DRAGOȘ PUIA 1,2, TUDOR MARIAN PROCA 3,4,
MARIUS IVĂNUȚĂ 2*, GEORGE DANIEL RĂDĂVOI 3,41“Grigore T Popa” University of Medicine and Pharmacy, Faculty of Medicine, 16 Universității Street, Iași, Romania
2 “CI Parhon” Hospital, Department of Urology, 50 Carol I Boulevard, Iași, Romania
3 “Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, 37 Dionisie Lupu Street, Bucharest, Romania
4 “Prof Dr Th Burghele” Clinical Hospital, 20 Panduri Street, Bucharest, Romania -
EFFICACY OF NATURAL POLYPHENOLIC COMPOUNDS FROM BILBERRY AND BLUEBERRY ON THE METABOLIC ALTERATIONS INDUCED BY STREPTOZOTOCIN IN RATS
RUXANDRA ȘTEFANESCU 1, EMÖKE FÜLÖP 2*, LILIANA DEMIAN 3, CAMIL VARI 4, BIANCA-EUGENIA ŐSZ 4, ALEXANDRA GROȘAN 4, ESZTER LACZKO-ZÖLD 1, CALIN BOGDAN CHIBELEAN 5,6
1Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu-Mureș, 38 Gh. Marinescu Street, 540139, Târgu-Mureș, Romania
2 Emergency County Hospital Târgu Mureș, Department of Pathology, 50 Gh. Marinescu Street, 540136, Târgu Mureș, Romania 3Immunology Laboratory, Center for Advanced Medical and Pharmaceutical Research, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu-Mureș, 38 Gh. Marinescu Street, 540139, Târgu-Mureș, Romania
4 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “George Emil Palade” University of Medicine,
Pharmacy, Science and Technology of Târgu-Mureș, 38 Gh. Marinescu Street, 540139, Târgu-Mureș, Romania
5 Department of Urology, Mureș County Clinical Hospital, 1 Gh. Marinescu Street, 540103, Târgu-Mureș, Romania
6 Department of Urology, Faculty of Medicine, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu-Mureș, 38 Gh. Marinescu Street, 540139, Târgu-Mureș, Romania -
INFLUENCE OF SOLVENT TYPE ON THE PHENOLIC CONTENT AND ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF ECHIUM VULGARE L. EXTRACTS
IVANA BOŠKOVIĆ 1*, DRAGUTIN ĐUKIĆ 2, PAVLE MAŠKOVIĆ 2, LEKA MANDIĆ 2
1University of East Sarajevo, Faculty of Agriculture, 71 123 East Sarajevo, Bosnia and Herzegovina 2University of Kragujevac, Faculty of Agronomy, 32 000 Čačak, Serbia
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INFLUENCE OF TYPE 2 DIABETES ON THE ANTHROPOMETRIC INDICES, BODY COMPOSITION AND MICRONUTRIENT STATUS OF PATIENTS SUBMITTED TO LAPAROSCOPIC SLEEVE GASTRECTOMY
DANIELA CIOBÂRCĂ 1, ADRIANA FLORINELA CĂTOI 2*, CĂTĂLIN COPĂESCU 3, IOANA DELIA POP 4, DOINA MIERE 1, GIANINA CRIȘAN 5
1Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
2 Department of Physiopathology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012
Cluj-Napoca, Romania 3“G. T. Popa” University of Medicine and Pharmacy, Iași, Romania
4 Department of Exact Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, 400372 ClujNapoca, Romania
5 Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania -
ANTIOXIDANT AND IN VITRO CYTOTOXIC ACTIVITY OF COMMERCIAL LEMONGRASS, SEA BUCKTHORN AND BASIL ESSENTIAL OILS, AGAINST COLORECTAL CANCER CELL LINE HCT 116
ALINA ANTON 1,2#, ELENA ALINA MOACĂ 1,2#, CRISTIAN ANDREI SARAU 3*, ȘTEFANIA
DINU 4, ALEXANDRA DENISA SEMENESCU 1,2, IOANA GABRIELA MACAȘOI 1,2, CRISTINA ADRIANA DEHELEAN 1,21Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041 Timișoara, Romania
2 Research Centre for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041 Timișoara, Romania
3 Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041 Timișoara, Romania
4 Faculty of Dental Medicine, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041 Timișoara, Romania -
TESTICULAR INJURIES DUE TO SUBACUTE COMBINED EXPOSURE TO CADMIUM AND LEAD IN RATS
CARMEN SOLCAN 1, BOGDAN GABRIEL ŞLENCU 2*, LUCIA CARMEN TRINCĂ 3,4, IULIANA MOTRESCU 3,4, ADRIANA PETROVICI 1, GHEORGHE SOLCAN 5
1Department Preclinics, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine of Iaşi, 8 M. Sadoveanu, 700489 Iaşi, Romania
2 Department of Pharmaceutical Sciences I, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy of Iaşi, 16 Universităţii, 700115, Romania
3 Department of Exact Sciences, Faculty of Horticulture, “Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine of Iaşi, 3 M. Sadoveanu, 700490 Iaşi, Romania
4 Research Institute for Agriculture and Environment (ICAM), 14 M. Sadoveanu, 700489 Iaşi, Romania
5 Department Clinics, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine of Iaşi, 8 Aleea M. Sadoveanu, 700489 Iaşi, Romania -
EVALUATION OF ANTIPYRETICS USE AND HEAT SENSITIVITY IN PATIENTS WITH MULTIPLE SCLEROSIS AND IT IS IMPACT ON QOL
ABDULAZIZ ALHOSSAN 1,2*, NOURA F. ALAIFAN 1, BADRIA T. ALTHWAINI 1, AJAZ AHMAD 1
1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
2 Corporate of Pharmacy Services, King Saud University Medical City, Riyadh, Saudi Arabia -
BREAST CANCER RESPONSE TO NEOADJUVANT CHEMOTHERAPY QUANTIFIED BY RESIDUAL CANCER BURDEN (RCB) SCORE
CRISTIAN NICOLAE POPA 1, RODICA DANIELA BÎRLĂ 1,2*, DANIELA ELENA DINU 1,2, CRISTINA IOSIF 3, EVELINA BOGASERIU 4, IOAN NICOLAE MATEȘ 1,2
1Department of General Surgery I, “Sf. Maria” Clinical Hospital, Bucharest, Romania
2 “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3 Department of Pathology, “Sf. Maria” Clinical Hospital, Bucharest, Romania 4Department of Oncology, “Sf. Maria” Clinical Hospital, Bucharest, Romania -
SYNERGISTIC INTERACTION BETWEEN LAMIACEAE ESSENTIAL OILS AND ANTIFUNGAL DRUGS AGAINST CANDIDA ALBICANS ATCC 10231
NELI ERMENLIEVA 1, EMILIYA GEORGIEVA 2, SILVIYA MIHAYLOVA 3*, SYLVIA STAMOVA 4, KRASIMIRA LALEVA 5, GABRIELA TSANKOVA 1, ANTOANETA TSVETKOVA 3
1Department of Microbiology and Virusology, Medical University of Varna, Bulgaria
2 Training Sector “Medical Laboratory Assistant”, Medical College-Varna, Medical University of Varna, Bulgaria
3 Training Sector “Assistant Pharmacist”, Medical College-Varna, Medical University of Varna, Bulgaria
4 Department of Pharmaceutical Chemistry, Pharmacy Faculty, Medical University of Varna, Bulgaria
5 Department of Social Medicine and Health Care Organization, Medical University of Varna, Bulgaria -
EVALUATION OF TAPERING BIOLOGICAL THERAPY IN RHEUMATOID ARTHRITIS
DIANA IOANA MANUELA TEAHA 1#, DOREL DULĂU 2#, DANIELA ELENA POPA 3*, GEORGE TRAIAN ALEXANDRU BURCEA-DRAGOMIROIU 3, ANNE-MARIE CIOBANU 3#, TIBERIU SEBASTIAN NEMETH 4
1Clinical County Emergency Hospital Oradea, 2 Corneliu Coposu Street, Oradea, Romania
2 University of Oradea, Doctoral School of Biomedical Sciences, Medicine Field, 1 Universității Street, Oradea, Romania 3Department of Drug Control, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy Bucharest, 6
Traian Vuia Street, Bucharest, Romania
4 University of Oradea, Faculty of Medicine and Pharmacy, 29 Nicolae Jiga Street Oradea, Romania -
SYSTEMIC AMPICILLIN DIMINISHES FORMALIN-INDUCED NOCICEPTION IN RATS
GUADALUPE DEL CARMEN BAEZA-FLORES 1, JORGE ELIAS TORRES-LÓPEZ 1, CRYSTELL
GUADALUPE GUZMÁN-PRIEIGO 2*1Pain Mechanisms Laboratory, Academic Division of Health Sciences, Autonomous Juarez University of Tabasco, Villahermosa, Tabasco, México
2 Cardiometabolism Laboratory, Academic Division of Health Sciences, Autonomous Juarez University of Tabasco,
Villahermosa, Tabasco, México -
ASCORBATE INHIBITS THE ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION MEDIATED RELAXATION IN RESISTANCE ARTERIES
BOGDAN HUZUM, DRAGOMIR NICOLAE ŞERBAN *, IONUŢ TUDORANCEA, RADU ILIESCU, ANCA GALACTION, IONELA LĂCRĂMIOARA ŞERBAN
“Grigore T. Popa University” of Medicine and Pharmacy Iaşi, 16 Universităţii Street, 700115 Iași, România
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ANTITUMOR EFFECTS OF ANLOTINIB HYDROCHLORIDE ON HUMAN PANCREATIC CANCER CELLS
LIQIONG LIU 1, ZHIPING LI 2, YONGQI LI 2, LILI LIU 2*
1Department of Oncology, Daqing Oilfield General Hospital, Daqing City, 163000, China
2 Department of Pharmacy, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang City, 157011, China -
A NOVEL LC-MS/MS ANALYTICAL METHOD FOR SIMULTANEOUS DETECTION OF ARTICAINE, ARTICAINE ACID, LIDOCAINE AND MONOETHYLGLYCINEXYLIDIDE (MEGX) IN HUMAN PLASMA
TSVETAN TSVETANOV 1*, DESISLAV TOMOV 2
1Department of Oral surgery, Dental Faculty, Medical University of Plovdiv, Bulgaria
2 Department of Bioorganic chemistry, Faculty of Pharmacy Medical University of Plovdiv, Bulgaria -
THE COVID-19 PANDEMIC′S IMPACT ON HEALTHCARE PROFESSIONALS′ MENTAL HEALTH
MATEI PALIMARICIUC 1,2#, ANA CATERINA CRISTOFOR 1,2, CRISTINA ELENA DOBRE 2, VLAD TEODOR IACOB 1,2, TUDOR FLOREA 1,2, MAGDALENA BÎRSAN 3#, CĂTĂLINA DANIELA STAN 3*, ȘADIYE-IOANA SCRIPCARIU 4, ROXANA CHIRIȚĂ 1,2
1“Grigore T. Popa” University of Medicine and Pharmacy from Iaşi, Faculty of Medicine, III Medical Department, 16
Universităţii Street, 700115, Iaşi, România
2 Socola Institute of Psychiatry, 36 Bucium Street,700282, Iași, Romania
3 “Grigore T. Popa” University of Medicine and Pharmacy from Iaşi, Faculty of Pharmacy, Department of Pharmaceutical
Management and Marketing, 16 Universităţii Street, 700115, Iaşi, România
4 “Grigore T. Popa” University of Medicine and Pharmacy from Iaşi, Faculty of Medicine, Mother and Child Health Department, 16 Universităţii Street, 700115, Iaşi, Romania -
THE ANALYSIS OF PRESCRIPTIONS AND DISTRIBUTION OF MEDICINES IN THE PREVENTION OF MEDICATION ERRORS IN COMMUNITY PHARMACIES
NICOLETA CHEPTANARI-BIRTA 1*, MIHAIL BRUMĂREL 1, VLADIMIR SAFTA 1, LARISA SPINEI 2, STELA ADAUJI 1
1Vasile Procopisin Department of Social Pharmacy, “Nicolae Testemițanu” State University of Medicine and Pharmacy, Chișinău, Republic of Moldova
2 Nicolae Testemițanu Department of Social Medicine and Management, “Nicolae Testemițanu” State University of Medicine and Pharmacy, Chisinau, Republic of Moldova