Romanian Society of Pharmaceutical Sciences
 

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CHANGES IN BIOCHEMICAL PARAMETERS IN DIABETES AFTER SUCCESSFUL DIRECT-ACTING ANTIVIRAL TREATMENT OF HEPATITIS C VIRUS

MARIAN-SORIN POPESCU 1, DAN-MIHAI FIRU 1, VLAD PĂDUREANU 1, CRISTINA MARIA
MĂRGINEAN 1, DANIEL-CRISTIAN PÎRVU 1, ANDREI OSMAN 2*, RADU MITRUȚ 3, SIMONA
PÂRVU 4, DRAGOȘ NICOLAE MĂRGĂRITESCU 5, DANIELA CĂLINA 6, ANCA OANA
DOCEA 7, PAVEL CĂLIN COBELSCHI 8, PAUL MITRUȚ 1

1Department of Medical Semiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
2 Department of Anatomy and Embryology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania 3Department of Cardiology, University and Emergency Hospital, 050098 Bucharest, Romania
4 Department of Hygiene and Medical Ecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest,
Romania
5 Department of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
6 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
7 Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
8 Department of Medical and Surgical Specialties, Faculty of Medicine, Transylvania University of Brașov, 500019 Brașov, Romania

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Diabetes Mellitus (DM) and Chronic Hepatitis C Virus (HCV) have a strong interconnection in general practice. Recent studies have correlated insulin resistance risk with liver dysfunction. Haptoglobin is a biomarker that is modified in liver disease and is involved in metabolic diseases. Our study aims to investigate the changes in haptoglobin and bilirubin levels after directacting antiviral (DAA) treatment for viral hepatitis C in relation to diabetes status and hypertension in order to identify potential biomarkers for the prognosis of liver disease in diabetic patients after obtaining sustained virological response (SVR). Eighty patients (40 with Type 2-DM (T2DM) and 40 without T2DM) treated with DAAs for HCV infection that obtained SVR were monitored for biochemical markers before and 3 years after treatment. We report that HCV clearance improves not only the biomarkers of liver function but also TB and Hp, which are strongly connected with insulin resistance in T2DM, leading to better control of blood glucose levels, obesity, and lipid metabolism. These two biomarkers should be further investigated not only to understand better the physiopathological pathways by which they affect TD2M progression, but also how their levels might be raised in the pursuit of better control of diabetes, cardiovascular complications, and other diseases.