Romanian Society of Pharmaceutical Sciences
 

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COMPARATIVE RESEARCH BETWEEN SOLIFENACINTAMSULOSIN VERSUS TAMSULOSIN ALONE IN EXPULSION OF JUXTAVESICAL URETERAL STONES

CĂTĂLIN PRICOP 1,2, VIOREL JINGA 3,4, DRAGOȘ PUIA 1,2, TUDOR MARIAN PROCA 3,4,
MARIUS IVĂNUȚĂ 2*, GEORGE DANIEL RĂDĂVOI 3,4

1“Grigore T Popa” University of Medicine and Pharmacy, Faculty of Medicine, 16 Universității Street, Iași, Romania
2“CI Parhon” Hospital, Department of Urology, 50 Carol I Boulevard, Iași, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, 37 Dionisie Lupu Street, Bucharest, Romania
4“Prof Dr Th Burghele” Clinical Hospital, 20 Panduri Street, Bucharest, Romania

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The European Association of Urology Guidelines (EAU) recommends medical expulsive therapy using alpha-blocking medication for the treatment of pelvic ureteral stones smaller than 10 mm if urinary drainage is not mandatory. We performed a randomised, prospective study to assess whether the combination of tamsulosin and solifenacin provides additional benefits over tamsulosin alone in the expulsion treatment of pelvic ureteral stones. A total of 236 patients were included in this study. Patients in group A received tamsulosin 0.4 mg/day, while patients in group B received tamsulosin 0.4 mg/day and solifenacin 10 mg/day. The main groups were divided into subgroups according to the size of the calculus- subgroups A1 and B1 - patients with calculi between 5 - 6 mm and A2 and B2 - patients with calculi between 7 - 8 mm in size. Patients in subgroups A2 and B2 had shorter expulsion intervals of the calculus compared to patients in subgroups A1 and B1 (5.2 days vs. 3.81 days and 6.42 days vs. 3.79 days), required lower doses of NAIDS (2.95 tablets/day vs. 1.82 tablets/day and 3.1 tablets/day vs. 2.05 tablets/day) and presented an improvement in symptom scores. Our data suggest that the combined treatment of tamsulosin and solifenacin brings benefits to medical expulsion therapy of pelvic ureteral stones.