Romanian Society of Pharmaceutical Sciences

« Back to Farmacia Journal 4/2022

INFLUENCE OF TYPE 2 DIABETES ON THE ANTHROPOMETRIC INDICES, BODY COMPOSITION AND MICRONUTRIENT STATUS OF PATIENTS SUBMITTED TO LAPAROSCOPIC SLEEVE GASTRECTOMY

DANIELA CIOBÂRCĂ 1, ADRIANA FLORINELA CĂTOI 2*, CĂTĂLIN COPĂESCU 3, IOANA DELIA POP 4, DOINA MIERE 1, GIANINA CRIȘAN 5

1Department of Bromatology, Hygiene, Nutrition, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
2Department of Physiopathology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012
Cluj-Napoca, Romania 3“G. T. Popa” University of Medicine and Pharmacy, Iași, Romania
4Department of Exact Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, 400372 ClujNapoca, Romania
5Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania

Download Full Article PDF

The objectives of this study were to determine whether or not the presence type 2 diabetes (T2D) is associated with significantly less postoperative weight loss and to evaluate the impact of T2D on body composition and micronutrient status in patients submitted to laparoscopic sleeve gastrectomy (LSG). The study was conducted on 50 men and women (12 with T2D) that were evaluated preoperatively and at 6 and 12 months following LSG. Patients with T2D lost significantly less weight and visceral fat at 12 months following LSG compared with their counterparts without T2D, despite comparable BMI at baseline. Also, patients with T2D exhibited a significantly higher fat-free mass at the end of the follow-up period (but also lost less weight), although the total fat mass loss did not differ significantly between patients with and without T2D both pre- and postoperatively. 25(OH) D deficiency was present in all patients in baseline and this abnormality persisted throughout the follow-up period, irrespective of T2D status and routine nutritional supplementation; vitamin B12 serum levels were significantly higher (but keeping within the normal range) in the T2D group pre- and post-LSG. T2D negatively impacts both weight loss and body composition improvement following LSG. Except for vitamin B12, micronutrient levels evaluated herein were comparable between the two groups.