Romanian Society of Pharmaceutical Sciences
 

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HYDROPHOBICALLY MODIFIED DEXTRAN ESTERS AS POTENTIAL EXTERNAL BIOCIDES

CRISTINA G. TUCHILUS 1, DALILA BELEI 2, ADINA COROABA 3, MARIETA NICHIFOR 4,
MAGDALENA CRISTINA STANCIU 4*

1“Grigore T. Popa” University of Medicine and Pharmacy, Department of Microbiology, Faculty of Medicine, 16 University Street, 700115, Iaşi, Romania
2“Al. I. Cuza” University of Iaşi, Faculty of Chemistry, Department of Organic Chemistry, 11 Carol I Avenue, 700506, Iaşi,
Romania
3“Petru Poni” Institute of Macromolecular Chemistry, Centre of Advanced Research in Bionanoconjugates and
Biopolymers, 41A Grigore Ghica Voda Alley, Iaşi, 700487, Romania
4“Petru Poni” Institute of Macromolecular Chemistry, Department of Natural Polymers, Bioactive and Biocompatible Materials, 41 A Grigore Ghica Voda Alley, 700487, Iaşi, Romania

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Amphiphilic dextran-based esters were synthesized by coupling several disubstituted 1,2,3-triazole derivatives on the polysaccharide. The polymers were characterized by elemental analysis and spectroscopy measurements: X-ray photoelectron (XPS), Fourier transform infrared (FTIR), carbon-13 nuclear magnetic resonance (13C NMR). Triazole derivatives and their corresponding dextran esters showed a moderate to good antimicrobial activity, the antifungal activity being stronger than the antibacterial one. Halogenated polymers proved to be potential external biocides due to their both bactericidal and fungicidal activity.