Romanian Society of Pharmaceutical Sciences
 

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HYDROPHOBICALLY MODIFIED DEXTRAN ESTERS AS POTENTIAL EXTERNAL BIOCIDES

CRISTINA G. TUCHILUS 1, DALILA BELEI 2, ADINA COROABA 3, MARIETA NICHIFOR 4,
MAGDALENA CRISTINA STANCIU 4*

1“Grigore T. Popa” University of Medicine and Pharmacy, Department of Microbiology, Faculty of Medicine, 16 University Street, 700115, Iaşi, Romania
2 “Al. I. Cuza” University of Iaşi, Faculty of Chemistry, Department of Organic Chemistry, 11 Carol I Avenue, 700506, Iaşi,
Romania
3 “Petru Poni” Institute of Macromolecular Chemistry, Centre of Advanced Research in Bionanoconjugates and
Biopolymers, 41A Grigore Ghica Voda Alley, Iaşi, 700487, Romania
4 “Petru Poni” Institute of Macromolecular Chemistry, Department of Natural Polymers, Bioactive and Biocompatible Materials, 41 A Grigore Ghica Voda Alley, 700487, Iaşi, Romania

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Amphiphilic dextran-based esters were synthesized by coupling several disubstituted 1,2,3-triazole derivatives on the polysaccharide. The polymers were characterized by elemental analysis and spectroscopy measurements: X-ray photoelectron (XPS), Fourier transform infrared (FTIR), carbon-13 nuclear magnetic resonance (13C NMR). Triazole derivatives and their corresponding dextran esters showed a moderate to good antimicrobial activity, the antifungal activity being stronger than the antibacterial one. Halogenated polymers proved to be potential external biocides due to their both bactericidal and fungicidal activity.