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MINI-REVIEW ON THE IMPLICATIONS OF GENE POLYMORPHISM IN THE METABOLISM OF XENOBIOTICS

ALINA-COSTINA LUCA 1, ALIN CIOBICA 2, WALTHER BILD 1,5, ALEXANDRINA-STEFANIA CURPAN 3*, ELENA EMANUELA BRAHA 4

1“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, 700115, Iași, Romania
2“Alexandru Ioan Cuza” University of Iasi, Department of Research, Faculty of Biology, 700505, Iași, Romania
3“Alexandru Ioan Cuza” University of Iasi, Department of Biology, Faculty of Biology, 700505, Iași, Romania
4“C.I. Parhon” National Institute of Endocrinology, 011863, Bucharest, Romania
5Center of Biomedical Research of the Romanian Academy, 700481, Iași Romania

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One of the most common medical issues in children and adults is accidental poisonings ranging from medicines to toxic substances such as alcohol and toluene and even metals like iron and lead. The way these substances are metabolised depends on a plethora of factors such as age, sex and even ethnicity. Besides these factors, there is one that holds an even more significant weight on how substances are metabolised - genes, or more precisely, alleles of specific genes. In recent years, genetic studies have significantly increased in number, and more and more genetic polymorphisms are being discovered and studied for their different effects compared to wild types. We performed a literature search on the subject comprising studies focusing on the most common substances in intoxications, as well as polymorphisms of CYP450 isoenzymes, HLA system and others. We obtained various studies on the subject highlighting differences in expression depending on the present allele, with some having diametral opposed effects while others being null. Thorough knowledge of these complex mechanisms is an important first step towards the development of tests to detect susceptibility to severe side effects and towards rapidly customising the therapeutic approach.