Farmacia Journal 4/2024
Volume 72 | Number 4 | Year 2024
Download this issue’s covers, and announcements.
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INTEGRATING NUTRACEUTICALS IN THE ONE HEALTH FRAMEWORK: A PATH TO HOLISTIC HEALTH SOLUTIONS
MIRUNA-MARIA APETROAEI 1, INES-ELENA ADAM-DIMA 1, NASTASIA BELC 2*, FLORENTINA-ISRAEL ROMING 3, FLORICA CONSTANTINESCU 2, DENISA DUȚĂ 2, ADRIAN MACRI 4, DENISA-IOANA UDEANU 1
1 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, District 2, Bucharest, Romania
2 National Research and Development Institute for Food Bioresources – IBA Bucharest, 5, Ancuța Băneasa Street, District 2, Bucharest, Romania
3 Faculty of Biotechnology, University of Agronomic Sciences and veterinary Medicine of Bucharest, 59 Mărăști Boulevard, District 1, Bucharest, Romania
4 Animal Nutrition Department, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Calea Mănăştur Street, Cluj-Napoca, Romania -
THERAPEUTIC POTENTIAL OF HYSSOPUS OFFICINALIS L. IN SKIN PROBLEMS – A REVIEW
TIJANA MIĆOVIĆ 1,2*, JELENA S. KATANIĆ STANKOVIĆ 3
1 Institute for Medicines and Medical Devices of Montenegro, Bulevar Ivana Crnojevića 64a, 81000 Podgorica, Montenegro
2 University of Montenegro, Faculty of Medicine, Kruševac bb, 81000 Podgorica, Montenegro
3 Institute for Information Technologies Kragujevac, Department of Science, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia -
HYDROXYFLAVONE COMPLEXES WITH BIOGENIC AND ABIOGENIC METALS
CLAUDIU RADU 1, ANDREEA ALEXANDRA OLTEANU 2*, CORINA CRISTINA ARAMĂ 2, VALENTINA UIVAROȘI 1
1 Department of General and Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania
2 Department of Analytical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania -
MOLECULAR CHARACTERIZATION OF TRANS FERULIC ACID: β-CYCLODEXTRIN INCLUSION COMPLEX. EXPERIMENTAL AND THEORETICAL APPROACH
MIHAELA MIC 1, ADRIAN PÎRNĂU 1*, CĂLIN G. FLOARE 1, MARIA O. MICLĂUS 1, IRINA KACSO 1, BIANCA M TIHĂUAN 2,3, MĂDĂLINA AXINIE (BUCOS) 3,4, GABRIEL MARC 5, OVIDIU ONIGA 5, OVIDIU CRIȘAN 6
1 National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donat, 400293, Cluj- Napoca, Romania
2 Research Institute of the University of Bucharest – ICUB, 91-95 Splaiul Independentei, 50567, Bucharest, Romania
3 Research & Development for Advanced Biotechnologies and Medical Devices, SC Sanimed International Impex SRL, Călugăreni, Romania
4 Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 011061 Bucharest, Romania
5 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012, Cluj-Napoca, Romania
6 Department of Organic Chemistry, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012, Cluj-Napoca, Romania -
EVALUATION OF SYNERGISTIC ACTIVITY OF LAMIACEAE ESSENTIAL OILS WITH ANTIFUNGAL DRUGS AGAINST C. ALBICANS BY TRACKING THE DYNAMICS OF MICROBIAL DENSITY IN SUSPENSION
NELI ERMENLIEVA 1, GABRIELA TSANKOVA 1, SYLVIA STAMOVA 2, ANTOINETA TSVETKOVA 3, EMILIA GEORGIEVA 3, SILVIYA MIHAILOVA 3*
1 Department of Microbiology and Virology, Medical University, Varna, Bulgaria
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University, Varna, Bulgaria
3 Medical College, Medical University, Varna, Bulgaria -
QUERCETIN ENHANCES THE ANTI-TUMOR ACTIVITY OF DOXORUBICIN IN IMR-32 NEUROBLASTOMA CELLS
GEORGIANA MOISE 1#, ANDREEA GEAMANTAN-SÎRBU 2,3#, CRISTIAN SEBASTIAN VLAD 4*, DALIBORCA VLAD 4, CRISTINA DUMITRESCU 2,3, LAURENȚIU SIMA 5
1 Doctoral School “Victor Babeş” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
2 Departament of Toxicology, Drug Industry, Management and legislation, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
3 Research Centre for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
4 Department of Pharmacology, Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
5 Department of Surgical Semiology I and Thoracic Surgery, Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy Timişoara, 2 Eftimie Murgu Square, 300041, Timişoara, Romania -
SOLUPLUS AND SOLUTOL HS-15 OLMESARTAN MEDOXOMIL NANOMICELLE BASED ORAL FAST DISSOLVING FILM: IN VITRO AND IN VIVO CHARACTERIZATION
HALAH TALAL SULAIMAN, NAWAL A. RAJAB *
Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq
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PDMAEMA/SILK SERICIN HYBRID NANOCARRIERS FOR EFFICIENT DELIVERY OF 5-FLUOROURACIL AND OXALIPLATIN TO HUMAN COLORECTAL ADENOCARCINOMA TUMOUR CELLS
ARIANA HUDIȚĂ 1,2, DIANA IULIANA STANCIU 1, MIRELA VIOLETA ȘERBAN 1, BIANCA GĂLĂȚEANU 1*, IONUȚ-CRISTIAN RADU 3, EUGENIA TANASĂ 4, CĂTĂLIN ZAHARIA 3, GEORGE-TRAIAN-ALEXANDRU BURCEA-DRAGOMIROIU 5, CRISTIAN-DANIEL MARINECI 5, OCTAV GINGHINĂ 6,7
1 Faculty of Biology, University of Bucharest, Bucharest, Romania
2 Research Institute of the University of Bucharest, University of Bucharest, Bucharest, Romania
3 Faculty of Chemical Engineering and Biotechnology, University of Science and Technology Politehnica Bucharest, Bucharest, Romania
4 Faculty of Applied Science, National University of Science and Technology Politehnica Bucharest, Bucharest, Romania
5 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
6 Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania
7 Department of Surgery 3, “Prof. Dr. Al. Trestioreanu” Institute of Oncology Bucharest, Romania -
IMPACT OF GLP-1 RECEPTOR AGONIST SEMAGLUTIDE ON CAROTID INTIMA-MEDIA THICKNESS IN DIABETES MELLITUS
LIJIANG LI 1, AIFANG WANG 1, SHAN WU 1, YING LV 2*
1 Department of Endocrinology, Yuhuan People’s Hospital, Yuhuan, 317600, Zhejiang, China
2 Department of Ultrasonography, Yuhuan People’s Hospital, Yuhuan, 317600, Zhejiang, China -
REGRESSION OF LIVER FIBROSIS IN HCV CIRRHOTIC PATIENTS TREATED WITH INTERFERON-FREE THERAPIES
ANCA LEUŞTEAN 1,3, MIHAELA CRISTINA OLARIU 1,3*, NICOLETA MIHAI 1, CĂTĂLIN TILIŞCAN 2,3, VIOLETA MOLAGIC 1,3, IRINA DUPORT-DODOŢ 2,3, LAURENŢIU MIHĂIŢĂ STRATAN 1,3, ŞTEFAN SORIN ARAMĂ 2, VICTORIA ARAMĂ 1,3
1 Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021, Bucharest, Romania
2 Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021, Bucharest, Romania
3 “Professor Doctor Matei Balş” National Institute for Infectious Diseases, 021105, Bucharest, Romania
4 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020021, Bucharest, Romania -
ANTIBACTERIAL ACTIVITY OF FALOAK (STERCULIA QUADRIFIDA R. BR) BARK: A PROMISING NATURAL ANTIBACTERIAL CANDIDATE
THERESIA IKA PURWANTININGSIH 1,3, BUDI PRASETYO WIDYOBROTO 1*, YUSTINA YUNI SURANINDYAH 1, WAYAN TUNAS ARTAMA 2
1 Department of Animal Production, Faculty of Animal Science, Universitas Gadjah Mada, Jl. Fauna No. 3 Bulaksumur, Yogyakarta 55281, Indonesia
2 Department of Biochemistry, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Jl. Fauna No. 2 Karangmalang Yogyakarta 55281, Indonesia
3 Animal Science Study Program, Faculty of Agriculture, Science and Health, University of Timor, Jl. El Tari Km. 9, Sasi, Kota Kefamenanu District, Timor Tengah Utara 85616, Indonesia -
BACTERIOLOGICAL AND MOLECULAR DETECTION OF FLUOROQUINOLONE RESISTANCE IN ESCHERICHIA COLI ISOLATED FROM WOMEN PATIENTS WITH URINARY TRACT INFECTIONS
BASMA M. AL-SARRAJ 1, EHAB D. SALMAN 1, DUNYA MUAYED AHMED 1, MUHANNAD I. MASSADEH 2, BATOL I. DHEEB 3*
1 Department of Biotechnology, College of Science, University of Baghdad, Iraq
2 Department of Biology and Biotechnology, Faculty of Science. The Hashemite University, Zarqa, Jordan
3 Department of pathological analysis, College of Applied science, Samarra University, Salah Aldeen, Iraq -
EFFECT OF MEDICINAL FUMIGATION TREATMENT WITH LONGDAN XIEGAN DECOCTION AT DIFFERENT TEMPERATURE THRESHOLD RANGES ON SPERM QUALITY IN PATIENTS
FENG GAO 1#, LIPING HE 1#, QIAOPING XU 2, CHENYU HUANG 3, YUESHU CAI 1, QIQI YU 1, YASHENG HUANG 1, MEI YANG 1*
1 Department of Urology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, China
2 Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Cancer Centre, Zhejiang University School of Medicine, Hangzhou, 310006, China
3 Zhejiang Hangzhou High School Qiantang, Hangzhou, 310000, China -
ANTIOXIDANT EFFICIENCY OF PARENTERAL ADMINISTRATION OF PURE APIS MELLIFERA VENOM IN A MURINE MODEL OF ARTHRITIS
CAMELIA ALINA GÎLCESCU (FLORESCU) 1, ION MÎNDRILĂ 2, ELENA CAMELIA STĂNCIULESCU 3, ANCA BERBECARU-IOVAN 4, FLORIN-LIVIU GHERGHINA 5*, CĂTĂLINA GABRIELA PISOSCHI 3
University of Medicine and Pharmacy of Craiova, 2-4 Petru Rareș Street, 200349, Craiova, Dolj County, Romania
1 PhD Student, Doctoral School
2 Department of Anatomy
3 Department of Pharmaceutical Biochemistry
4 Department of Pharmacology
5 Department of Physical Medicine and Rehabilitation -
COMPOSITION OF SCABIOSA OCHROLEUCA L. EXTRACTS PREPARED BY ULTRASONIC AND MICROWAVE METHODS AND THEIR ANTIRADICAL AND ANTIOXIDANT ACTIVITY ASSESSMENT
ARAILYM MUKANOVA 1*, UBAIDILLA DATKHAYEV 1, RAISSA ABDULLABEKOVA 2, MEREKE ALIMZHANOVA 3, DMITRIY KHRUSTALEV 2, ZHANAR ISKAKOVA 4, GALIYA IBADULLAYEVA 1
1 “Asfendiyarov” Kazakh National Medical University, 88 Tole bi Street, 050000, Almaty, Kazakhstan
2 Medical University of Karaganda, Karaganda city, 40 Gogol Street, 100008, Kazakhstan
3 Center of Physical-Chemical Methods of Research and Analysis, Al-Farabi Kazakh National University, Almaty, Kazakhstan
4 “L.N. Gumilyov” Eurasian National University, 2 Satpaev Street, 010000, Kazakhstan -
TEXTURE ANALYSIS AND COMPARATIVE SCREENING OF THE SENSORY PROPERTIES OF NEW SKINCARE PRODUCTS
MAGDALENA BÎRSAN 1,2, ALIN-VIOREL FOCȘA 2, ȘADIYE-IOANA SCRIPCARIU 3, PAULA ANTONOAEA 4*, CEZARA PINTEA 4, ROBERT ALEXANDRU VLAD 4, MIHAELA MONICA SCUTARIU 5, ADRIANA CIURBA 4
1 Medicine and Pharmacy Doctoral School, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, 540142, Târgu Mureș, Romania
2 “Grigore T. Popa” University of Medicine and Pharmacy from Iași, Faculty of Pharmacy, Department of Drug Industry and Pharmaceutical Biotechnology, 16 Universității Street, 700115, Iași, Romania
3 “Grigore T. Popa” University of Medicine and Pharmacy from Iași, Faculty of Medicine, Mother and Child Health Department, 16 Universităţii Street, 700115, Iași, Romania
4 “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, 38 Gheorghe Marinescu Street, 540142, Târgu Mureș, Romania
5 “Grigore T. Popa” University of Medicine and Pharmacy from Iași, Faculty of Dental Medicine, 16 Universităţii Street, 700115, Iași, Romania -
EFFECTS OF MAGNOLOL AND HONOKIOL ON SERUM IgE AND CELLS COUNT FROM BRONCHOALVEOLAR FLUID IN EXPERIMENTAL SEVERE ASTHMA WITH ACUTE LUNG INJURY
DIANA CEZARINA PETRESCU 1,#, ANDREI GHEORGHE VICOVAN 1,#, LOREDANA BEATRICE UNGUREANU 1, RALUCA STEFANIA STANESCU 1, DANIELA CONSTANTINESCU 1, ELENA IFTIMI 1, BRUNO ȘTEFAN VELESCU 2, CARMEN SOLCAN 3, CEZAR-CĂTĂLIN CARATAȘU 4, MOUSA SHA’A 1, LĂCRĂMIOARA OCHIUZ 1, CRISTINA MIHAELA GHICIUC 1*
1 “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, Romania
2 “Carol Davila” University of Medicine and Pharmacy of Bucharest, Romania
3 "Ion Ionescu de la Brad" University of Life Sciences, Iasi, Romania
4 Advanced Research and Development Center for Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, Romania -
IDENTIFICATION OF THERAPEUTIC TARGETS FOR POLYCYSTIC OVARY SYNDROME USING NETWORK PHARMACOLOGY AND COMPUTER SIMULATIONS
ISHA ZAFAR 1, MUNAZZAH MALIK 1, MIAN MUHAMMAD MUBASHER 2, MUHAMMAD TARIQ 3, QURBAN ALI 4#*, AJAZ AHMAD 5, MUHAMMAD BILAL 1#, SHIMING HAN 6#
1 Centre for Applied Molecular Biology, University of the Punjab, Lahore, Pakistan
2 Department of Information Technology, University of the Punjab, Lahore, Pakistan
3 National Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan.
4 Department of Plant Breeding and Genetics, Faculty of Agricultural Sciences, University of the Punjab, Lahore, Pakistan
5 Department of Clinical Pharmacy, College of Pharmacy, King Saud University, 11451 Riyadh, Saudi Arabia
6 School of Biological Sciences and Technology, Liupanshui Normal University, Liupanshui 55300, China -
DEVELOPMENT OF ANTIMICROBIAL HYDROGELS USING ALGINATE-CHITOSAN MATRIX ENHANCED WITH ESSENTIAL OILS
FLORIN ALEXANDRU JOIȚA 1#, ELIZA OPREA 2#, ADINA MAGDALENA MUSUC 3#, MAGDALENA MITITELU 1*, FLORICA MARINESCU 2, DUMITRU LUPULIASA 1, LUCIAN HÎNCU 1, ADRIAN COSMIN ROȘCA 4, STELUȚA CONSTANȚA BOROGHINĂ 1, IOANA ANDREEA POPESCU 1
1 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956, Bucharest, Romania
2 Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Portocalilor Street, 060101, Bucharest, Romania
3 Institute of Physical Chemistry – Ilie Murgulescu, Romanian Academy, 060021, Bucharest, Romania
4 Department of Drug Analysis, Biopharmacy and Biological Medicines, Faculty of Pharmacy, “Ovidius” University of Constanța, 900470, Constanța, Romania -
ISOLATION, IDENTIFICATION AND REDOX-MODULATION CAPACITY OF HEMOLYMPH’S SUBUNITS FROM RAPANA VENOSA INHABITING THE BULGARIAN BLACK SEA
ALBENA ALEXANDROVA 1*, LUBOMIR PETROV 1, ELINA TSVETANOVA 2, ALMIRA GEORGIEVA 2, LYUDMILA VELKOVA 3, VENTSESLAV ATANASOV 3, ALEKSANDER DOLASHKI 3, PAVLINA DOLASHKA 3, MILKA MILEVA 4
1 National Sports Academy, 21 Acad. St. Mladenov Street, 1700, Sofia, Bulgaria
2 Institute of Neurobiology, Bulgaria Academy of Sciences, 23 Acad. G. Bonchev Street, 1113, Sofia, Bulgaria
3 Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 9 Acad. G. Bonchev Street, 1113, Sofia, Bulgaria
4 “Stephan Angeloff” Institute of Microbiology, Bulgarian Academy of Sciences, 26 Acad. G. Bonchev Street, 1113, Sofia, Bulgaria -
MECHANISM AND THERAPEUTIC ROLE OF JIANPI JIEDU DECOCTION IN PROMOTING HEALING OF RECURRENT ORAL ULCER LESIONS IN RATS VIA NF-ΚB PATHWAY-MEDIATED OXIDATIVE STRESS AND INFLAMMATORY REBALANCE
XU ZHANG, WEN HU, LIANGFU ZHANG *
Department of Emergency, School of Stomatology, Hunan University of Traditional Chinese Medicine, Changsha Stomatological Hospital, Changsha, 410000, Hunan, China
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JUNIPERI GALBULUS: SCREENING OF PHYTOCHEMICALS AND BIOACTIVITY INVESTIGATION OF THE AQUEOUS EXTRACT
ALINA-ARABELA JOJIC 1, ALEXANDRA-DENISA SEMENESCU 1,2, IASMINA PREDESCU 1, GEORGE ANDREI DRĂCHICI 1,2, DELIA MUNTEAN 3, FLORINA ARDELEAN 1,2, GRAȚIANA RUSE 1, ARMAND GOGULESCU 3, IRINA ȘOICA 4, ALINA HEGHEȘ 1,5*, DIANA-SIMONA TCHIAKPE-ANTAL 1,2
1 Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
2 Research Centre for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
3 Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
4 Medical School, University College London, 74 Huntley Street, London WC1E 6DE, UK
5 Formulation and Technology of Drugs Research Centre, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara, Romania -
ANTIFUNGAL AND ANTIVIRULENCE ACTIVITY OF TANNIC ACID AGAINST DRUG-RESISTANT CANDIDA SPECIES
ANA L. RÍOS-LÓPEZ 1,#, VALERIA MUÑIZ-BERNAL 1,#, JORGE DÁVILA-AVIÑA 2, GLORIA M. GONZÁLEZ 1, ROGELIO DE J TREVIÑO-RANGEL 1, MIGUEL A. BECERRIL-GARCÍA 1, ORLANDO FLORES-MALDONADO 1*
1 Department of Microbiology, Faculty of Medicine and University Hospital “Dr. José Eleuterio González”, Autonomous University of Nuevo León, Av. Francisco I. Madero, Mitras Centro, 64460, Monterrey, Nuevo León, Mexico
2 Department of Microbiology and Immunology, Faculty of Biological Sciences, Autonomous University of Nuevo León, San Nicolas, Nuevo León, Mexico -
EFFECT OF HYDROXYUREA ON PULMONARY FUNCTION TESTS AND HAEMATOLOGICAL PARAMETERS IN ADULT PATIENTS WITH SICKLE CELL ANAEMIA
AZZA SAJID JABBAR 1*, MOHAMMED AL FARTTOSI 2, ABEER JAFAR MOHAMMED 3
1 Department of Pharmacology, College of Pharmacy, University of Basrah, Iraq
2 College of Medicine, University of Basrah, Iraq
3 Clinical pharmacist at Ibn Ghazwan Maternity and Children General Hospital, Basrah, Iraq -
DEVELOPMENT AND PRELIMINARY EVALUATION OF INTRANASAL HYDROCOLLOIDAL SYSTEMS BASED ON CHITOSAN AND PVA WITH INSULIN, FOR CENTRAL NERVOUS SYSTEM-ASSOCIATED DISEASES
ROXANA POPESCU 1, CRISTINA-ELENA DINU-PÎRVU 1,2, MIHAELA VIOLETA GHICA 1,2*, VALENTINA ANUȚA 1,2, LĂCRĂMIOARA POPA 1,2
1 Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, ”Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020950, Bucharest, Romania
2 Innovative Therapeutic Structures Research and Development Centre (InnoTher), “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania