EFFECTS OF MAGNOLOL AND HONOKIOL ON SERUM IgE AND CELLS COUNT FROM BRONCHOALVEOLAR FLUID IN EXPERIMENTAL SEVERE ASTHMA WITH ACUTE LUNG INJURY
DIANA CEZARINA PETRESCU 1,#, ANDREI GHEORGHE VICOVAN 1,#, LOREDANA BEATRICE UNGUREANU 1, RALUCA STEFANIA STANESCU 1, DANIELA CONSTANTINESCU 1, ELENA IFTIMI 1, BRUNO ȘTEFAN VELESCU 2, CARMEN SOLCAN 3, CEZAR-CĂTĂLIN CARATAȘU 4, MOUSA SHA’A 1, LĂCRĂMIOARA OCHIUZ 1, CRISTINA MIHAELA GHICIUC 1*
1 “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, Romania
2 “Carol Davila” University of Medicine and Pharmacy of Bucharest, Romania
3 "Ion Ionescu de la Brad" University of Life Sciences, Iasi, Romania
4 Advanced Research and Development Center for Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, Romania
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Bronchial asthma is susceptible to develop acute lung injury (ALI), a pathology with high mortality and morbidity needing novel therapeutic approach. Based on the protective effects of magnolol (MAGN) and honokiol (HON) in either asthma or ALI, we hypothesized that these have therapeutic effect in severe asthma complicated with ALI. The study aimed to evaluate the effects of MAGN and HONK on plasmatic IgE levels and cell differential count in bronchoalveolar lavage fluid (BALF) in an experimental severe asthma with LPS-induced ALI (OVA + LPS). Six groups of OVA + LPS BALB/c mice received, once daily: saline solution, dexamethasone 1 mg/kg (DEXA), magnolol 50 mg/kg (MAGN-D1) or 100 mg/kg (MAGN-D2) or honokiol 50 mg/kg (HONK-D1) or 100 mg/kg (HONK-D2 group). Serum IgE levels were similarly influenced by DEXA and by HONK and MAGN-D2, while the treatment with MAGN-D1 determined lower levels of serum IgE, statistically significant compared to DEXA group. On the other hand, MAGN and HONK in both doses did not have effect on inflammatory cells from BALF (neutrophils, eosinophils, lymphocytes and macrophages). The effects of higher dose of MAGN and both doses of HONK on IgE were quite similar to IgE DEXA group, but had no effect on inflammatory cells in BALF.
