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ANTIOXIDANT EFFICIENCY OF PARENTERAL ADMINISTRATION OF PURE APIS MELLIFERA VENOM IN A MURINE MODEL OF ARTHRITIS

CAMELIA ALINA GÎLCESCU (FLORESCU) 1, ION MÎNDRILĂ 2, ELENA CAMELIA STĂNCIULESCU 3, ANCA BERBECARU-IOVAN 4, FLORIN-LIVIU GHERGHINA 5*, CĂTĂLINA GABRIELA PISOSCHI 3

University of Medicine and Pharmacy of Craiova, 2-4 Petru Rareș Street, 200349, Craiova, Dolj County, Romania
1 PhD Student, Doctoral School
2 Department of Anatomy
3 Department of Pharmaceutical Biochemistry
4 Department of Pharmacology
5 Department of Physical Medicine and Rehabilitation

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This study was projected to assess the efficiency of bee venom (BV) samples in changing oxidative stress biomarkers in a murine model of CFA-induced knee osteoarthritis (KOA) in rats. Experimental rats were randomly divided into five groups: Ist – negative control, IInd – rats receiving a CFA injection in the knee joint, as a positive control, IIIrd – CFA-injected rats receiving BV i.p., IVth – CFA-injected rats treated with methotrexate (MTX) i.p. and the Vth – CFA-injected rats receiving both BV and MTX. At the end of the treatment, blood levels of oxidative stress markers. Oxidative stress biomarkers (MDA and NO) significantly decreased after administration of BV, MTX or their association compared with untreated CFA-injected animals. In conclusion, BV adjuvant therapy may be an option to increase the MTX antioxidant effect and improve health status in KOA, but it is important to adjust its therapeutic dose even if a pure BV sample proves a good in vitro free-radical scavenging effect.