Romanian Society of Pharmaceutical Sciences

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HYDROXYFLAVONE COMPLEXES WITH BIOGENIC AND ABIOGENIC METALS

CLAUDIU RADU 1, ANDREEA ALEXANDRA OLTEANU 2*, CORINA CRISTINA ARAMĂ 2, VALENTINA UIVAROȘI 1

1 Department of General and Inorganic Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania
2 Department of Analytical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania

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Hydroxyflavones represent a class of compounds of major importance due to the health benefits they have, with antioxidant, antibacterial, antiviral, anti-inflammatory, anticarcinogenic, antiischemic, hypolipemiant and antimutagenic effects. They are found naturally in a multitude of plant products fulfilling various defensive or metabolic roles. Due to their chemical structure, they facilitate the chelation of various metal ions. The chelation site differs according to the position and number of hydroxyl groups grafted onto the flavonoid nucleus. Through complexation with metal ions, changes in the biological activity of the flavone-ligands can occur, thus increasing their pharmacodynamic performance, modulating their hydrophilic or lipophilic character and influencing their pharmacokinetic profiles. Complexes of flavones with both biogenic and abiogenic metals have been described in studies where the effect of complexation on pharmacological properties was compared to the activity of the flavones from which they originated.