Farmacia Journal 1/2022
Volume 70 | Number 1 | Year 2022
Download this issue’s covers, and announcements.
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SATISFACTION WITH THE PROFESSION OF PHARMACISTS, ESPECIALLY DURING THE 2019 CORONAVIRUS PANDEMIC
WERONIKA GUZENDA 1#*, MAGDALENA WASZYK-NOWACZYK 1#, ADRIANNA JUSZCZAK 2, KAROLINA KAMASA 2, MAGDALENA CERBIN-KOCZOROWSKA 3, PIOTR MERKS 4, ARTUR BIAŁOSZEWSKI 5, MAREK SIMON 6
1Department of Pharmaceutical Technology, Pharmacy Practice Division, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland
2Student’s Pharmaceutical Care Group, Department of Pharmaceutical Technology, Pharmacy Practice Division, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland
3Department of Medical Education, Poznan University of Medical Sciences, 7 Rokietnicka Street, 60-806 Poznan, Poland
4Faculty of Medicine, Cardinal Stefan Wyszyński University, 1/3 Wóycickiego Street, 01-938 Warsaw, Poland
5Department of the Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, 1a Banacha Street, 02-091 Warsaw, Poland
6Chair and Department of Pathophysiology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznan, Poland -
IN VITRO INSIGHTS REGARDING THE ROLE OF MELANIN IN MELANOMA CELLS’ RESPONSE TO BETULINIC ACID TREATMENT
LAVINIA MELANIA BRATU 1#, IASMINA MARCOVICI 2,3#, IOANA MACASOI 2,3, ANIKO
MANEA 1*, BOGDAN NICULESCU 4#, FLAVIUS OLARU 1, ALINA HEGHES 2, CRISTINA DEHELEAN 2,3, DORINA CORICOVAC 2,31Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
2Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
3Research Centre for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
4Department of Sports and Health, “Constantin Brancuși” University, 210152, Târgu Jiu, Romania -
REAL-LIFE COMPARISON OF TOCILIZUMAB AND ANAKINRA ASSOCIATED WITH CORTICOSTEROID USE IN A COHORT OF HOSPITALIZED PATIENTS WITH SARS-CoV-2 INFECTION
LAURENȚIU MIHĂIȚĂ STRATAN 1,2#, CĂTĂLIN TILIȘCAN 1,2*, MIHAI LAZĂR 1,2, CONSTANȚA ANGELICA VIȘAN 1,2, SORIN ȘTEFAN ARAMĂ 1,2#, NICOLETA MIHAI 1,2, OANA GANEA 2, VICTORIA ARAMĂ 1,2#, ANDREEA LETIȚIA ARSENE 1, DANIELA ADRIANA ION 1,2
1“Carol Davila” University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu Street, Bucharest, Romania 2“Prof. Dr. Matei Balș” National Institute of Infectious Diseases, 1 Dr. Grozovici Street, Bucharest, Romania
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THE EFFECTS OF PLATELET RICH PLASMA AND COLD ATMOSPHERIC PLASMA ON RAT DORSAL SKIN FLAPS – A COMPARATIVE STUDY
BOGDAN CABA 1#, MONA ELISABETA DOBRIN 2#, IOANA CEZARA CABA 3*, IOANNIS GARDIKIOTIS 4, COSMIN TEODOR MIHAI 4, BOGDAN CIOROIU 5, LĂCRĂMIOARA IONELA ȘERBAN 6
1Department of Biomedical Sciences, Faculty of Medical Bioengineering, “Grigore T. Popa” University of Medicine and
Pharmacy, Iași, Romania
2Department of Clinical Biochemistry, Clinical Hospital of Pulmonary Disease, Iași, Romania
3Department of Toxicology, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania
4Advanced Research and Development Centre for Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania
5Romanian Academy, Iași Branch, Research Centre for Oenology, Iași, Romania
6Department of Physiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania -
SYNTHESIS OF 4-BENZYLSULFANYL AND 4-BENZYLSULFONYL CHALCONES. BIOLOGICAL EVALUATION AS ANTIMALARIAL AGENTS
HEGIRA RAMÍREZ 1,2, JOSÉ DOMÍNGUEZ 1, ESTEBAN FERNANDEZ-MOREIRA 3, JUAN RODRIGUES 4, MIGUEL RODRÍGUEZ 1, JAIME E. CHARRIS 1*
1Organic Synthesis Laboratory, Faculty of Pharmacy, Central University of Venezuela, 47206, Los Chaguaramos 1041-A, Caracas, Venezuela
2Facultad de Medicina, Universidad de Las Américas, Quito, Ecuador
3Escuela de Medicina, Universidad Espíritu Santo, Samborondón, Ecuador
4Departamento de Tecnología de Procesos Biológicos y Bioquímicos, División de Ciencias Biológicas, Universidad Simón
Bolívar, Valle de Sartenejas, 9063971, Caracas, Venezuela -
ANTIBIOTIC RESISTANCE PHENOTYPES OF S. AUREUS ISOLATES FROM NOSE AND PHARYNX OF HEALTHY YOUNG ADULTS
ADRIAN ANTON BĂNCESCU 1, TEODORA MARIA IONESCU 2, GABRIELA BĂNCESCU 2*, CARMEN LILIANA DEFTA 2
1Department of Epidemiology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2Department of Microbiology, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
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POLYPHENOLIC COMPOUNDS, ANTIOXIDANT ACTIVITY AND NEPHROPROTECTIVE PROPERTIES OF ROMANIAN TARAXACUM OFFICINALE
ALEXANDRA EPURE 1#, ALINA PÂRVU 2#, LAURIAN VLASE 3*, DANIELA BENEDEC 1, DANIELA HANGANU 1, ANA MARIA VLASE 4, ILIOARA ONIGA 1
1Department of Pharmacognosy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș
Street, Cluj-Napoca, Romania 2Department of Phisiopatology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș
Street, Cluj-Napoca, Romania
3Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, Cluj-Napoca, Romania 4Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 V. Babeș Street, Cluj-Napoca, Romania -
EFFECTS OF CHLOROGENIC ACID ON BEHAVIOR AND METABOLISM IN OVARIECTOMIZED RATS
ANTOANETA GEORGIEVA 1*, MILENA TODOROVA 1, MIROSLAV EFTIMOV 1, VASILENA KUZMANOVA 2, ATANAS KUZMANOV 2, KRASIMIR KUZMANOV 3, MILA VLASKOVSKA 4, STEFKA VALCHEVA-KUZMANOVA 1
1Department of Pharmacology and Clinical Pharmacology and Therapeutics, Medical University “Prof. Dr. Paraskev
Stoyanov”, Varna, Bulgaria
2Medical University “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
3Vivarium, Medical University “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
4Department of Pharmacology and Toxicology, Medical University, Sofia, Bulgaria -
SYNTHESIS OF AN AMPHIPHILIC COMPOUND DERIVED FROM MALONIC ACID FOR BONE TARGETING
CĂTĂLINA IONESCU 1, SIMONA CRISTINA RIZEA 2, ANDREEA PÎRVU 2, LAURIAN VLASE 3, VÉRONIQUE BARRAGAN-MONTERO 4, JOHNY NEAMȚU 2 ⃰
1University of Craiova, Faculty of Sciences, Department of Chemistry, 107i Calea București, 200144, Craiova, Romania
2University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, 2-4 Petru Rareş Street, 200349, Craiova, Romania
3“Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400023, Cluj-Napoca, Romania 4LBN, Univ Montpellier, Montpellier, France -
THE ROLE OF NATURAL BIOTHERAPEUTIC FACTORS IN PAIN AND FUNCTIONAL MANAGEMENT OF KNEE OSTEOARTHRITIS
MADALINA GABRIELA ILIESCU 1,2#, ELENA-VALENTINA IONESCU 1,2, IRINA TICA 1,3*, MARIUS-DRAGOS PRAZARU 3, FLORINA LIGIA POPA 4, MARIUS NICOLAE POPESCU 5,
MIHAI BERTEANU 5, LASZLO IRSAY 6#, VIORELA MIHAELA CIORTEA 6, FELIX VOINEA 1,3, BOGDAN OBADA 1,3, LUCIAN PETCU 1, ANDRA IULIA SUCEVEANU 1,31Faculty of Medicine, “Ovidius” University of Constanța, 1 University Alley, Campus – Corp B, 900470 Constanța, Romania
2Balneal and Rehabilitation Sanatorium Techirghiol, 34-40 Dr. Victor Climescu Street, 906100, Techirghiol, Romania
3County Emergency Teaching Hospital of Constanța, Tomis Boulevard, 900591 Constanța, Romania
4Physical Medicine and Rehabilitation Department, “Lucian Blaga” University of Sibiu, Faculty of Medicine, Academic Emergency Hospital of Sibiu, Victoriei Boulevard, 550024, Sibiu, Romania
5Department of Physical and Rehabilitation Medicine - “Elias” Emergency University Hospital, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania
6“Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, Department of Rehabilitation, Clinical Rehabilitation Hospital Cluj-Napoca, 8 Victor Babeș Street, 400000, Cluj-Napoca, Romania -
THE THERAPEUTICAL POTENTIAL OF GABAPENTIN COMBINED WITH DIOSCOREA OPPOSITA THUNB EXTRACTS ON A MURINE MODEL OF VASCULAR DEMENTIA BY MODULATING P2RX7 RECEPTORS
TANA ZHAO 1#, SHANGJUN CHEN 2#, LUDAN YUAN 2, DONGLIANG CAI 2*
1The Second Department of Pediatrics, The First Affiliated Hospital of Jiamusi University, Jiamusi City 154002, China 2Department of Geratology, The First Affiliated Hospital of Jiamusi University, Jiamusi City 154002, China
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EARLY USE OF REMDESIVIR IN OBESE MALE PATIENTS WITH COVID-19 CAN IMPROVE THE PROGNOSIS
CRISTINA POPESCU 1,2, ALINA IOANA ANDREI 1,2, ALEXANDRA CIREȘĂ 2, FELICIA STURZA 1,2*, FLORIN DUNĂ 2, GABRIEL ADRIAN POPESCU 1,2
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2“Prof. Dr. Matei Balș” National Institute of Infectious Diseases, Bucharest, Romania
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ELICITATION OF ORGANOSULFUR BIOACTIVE COMPOUNDS WITH Fe 3+ AND Zn 2+ IN CELL SUSPENSION CULTURE OF SINGLE GARLIC (ALLIUM SATIVUM L.)
FRIDA KUNTI SETIOWATI 1,3*, WAHYU WIDORETNO 1, SASANGKA PRASETYAWAN 2, BETTY LUKIATI 3
1Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia
2Chemistry Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia
3Biology Department, Faculty of Mathematics and Natural Sciences, State University of Malang, Malang, East Java, Indonesia -
THE PLASMA LEVEL OF SOLUBLE ENDOGLIN IN HYPERTENSIVE PATIENTS UNDERGOING LONG-TERM TREATMENT WITH CANDESARTAN
VALENTINA BUDA 1,2,#, MINODORA ANDOR 3,#, ANCA TUDOR 3*, OCTAVIAN CREȚU 3, CARMEN CRISTESCU 1, CORINA DANCIU 1,2, IONUT LEDEȚI 1,4, ZORIN CRAINICEANU 3,
MIRCEA ONEL 5, DIANA AURORA BORDEJEVIC 3, MIRELA CLEOPATRA TOMESCU 3, OANA SUCIU 6, LUCIAN PETRESCU 3,7, DANA EMILIA MAN 3,71Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara,
Romania
2Research Center for Pharmaco-Toxicological Evaluation, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
3Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timișoara,
Romania
4Advanced Instrumental Screening Centre, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square,
300041, Timișoara, Romania
5Faculty of Medicine, “Vasile Goldiș” Western University, 86 Liviu Rebreanu Street, 310045, Arad, Romania
6Department XIV, Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Square,
300041, Timișoara, Romania
7Cardiovascular Diseases Institute, 13 Gheorghe Adam Street, 300310, Timișoara, Romania -
APPLICATION OF RESPONSE SURFACE METHODOLOGY TO OPTIMIZE THE TECHNOLOGY OF METFORMIN ORAL DISSOLVING TABLETS
MARIANA DEMCHUK 1, MARIANA CHUBKA 2, BOHDANA PAVLIUK 1*, TARAS HROSHOVYI 1
1Department of Pharmacy Management, Economics and Technology, I. Horbachevsky Ternopil National Medical University, Ukraine
2Department of Pharmacy, I. Horbachevsky Ternopil National Medical University, Ukraine -
BIOSOLIDS’ USE INFLUENCES THE SYNTHESIS OF PHENOLIC COMPOUNDS AND THE ANTIOXIDANT ACTIVITY OF BASIL EXTRACTS FOR PHYTOPHARMACOLOGICAL PURPOSES
MARIAN BURDUCEA 1, MIRELA ARDELEAN 2*, CRISTINA POPA 3, ANDREI LOBIUC 4, TEODORA DANIELA MARTI 5, CRISTIAN-ALIN BARBACARIU 1
1“Alexandru Ioan Cuza” University, Research and Development Station for Aquaculture and Aquatic Ecology, km 5 IașiCiurea Road, 700718, Iași, Romania
2“Vasile Goldiș” Western University of Arad, “Aurel Ardelean” Institute of Life Sciences, 94 Revoluției Boulevard, 310025,
Arad, Romania
3“Aron Cotruș” Gymnasium School, 20 Petru Rareș Street, 310210, Arad, Romania 4“Ștefan cel Mare” University, 13 Universității Street, 720229, Suceava, Romania
5“Vasile Goldiș” Western University of Arad, Department of Microbiology, Virusology and Parasitology, 94 Revoluției Boulevard, 310025, Arad, Romania -
CHARD (BETA VULGARIS L. VAR CICLA) EXTRACT INHIBITS POLYOL PATHWAY AND HYPERGLYCAEMIA – INDUCED OXIDATIVE STRESS IN RAT LENS
ISMET BURCU TURKYILMAZ 1, BERTAN BORAN BAYRAK 1, OZLEM SACAN 1, LEVENT KABASAKAL 2, GOKSEL SENER 2, REFIYE YANARDAG 1*
1Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, 34320, Avcilar, Istanbul, Turkey
2Department of Pharmacology, Faculty of Pharmacy, Marmara University, 81010, Haydarpasa, Istanbul, Turkey -
EFFICACY OF TOCILIZUMAB IN THE TREATMENT OF PATIENTS WITH SEVERE INFECTION
SIMONA CLAUDIA CAMBREA 1,2#, LUCIAN CRISTIAN PETCU 3#, OANA CRISTINA ARGHIR 1,4#, IRINA MAGDALENA DUMITRU 1,2, SIMONA DIACONU 2, ELENA DUMEA 1,2*, IULIANA ROMELIA MITAN 2, SORINA DALIA CARP 2, STELA HALICHIDIS 1,2
1Faculty of Medicine, University “Ovidius” of Constanța, 1 Universității Alley, Campus, Corp B, 900470 Constanța, Romania
2Clinical Hospital of Infectious Diseases, 100 Ferdinand Boulevard, 900709 Constanța, Romania 3Faculty of Dentistry, University “Ovidius” of Constanța, 7 Ilarie Voronca Street, 900178 Constanța, Romania 4Clinical Hospital of Pneumophthysiology, 40 Sentinelei Street, 900002 Constanța, Romania -
FTIR, 1H NMR, TGA, TEM AND BIOLOGICAL STUDIES ON THE NEW SYNTHESIZED NANO ZIRCONIUM(IV) CAPTOPRIL HYPERTENSION DRUG COMPLEX
KHULOUD A. ALIBRAHIM *
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
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INFLUENCE OF DEXMEDETOMIDINE ON CLINICAL EFFICACY OF GENERAL ANESTHESIA AND STRESS RESPONSE IN CHILDREN
YAGUI LIANG, JINQIANG YUAN*, DIGUI WENG, QINGQING HUANG, SANYING CAI, JINGPING ZHAN
Department of Anaesthesiology, The Mindong Hospital Affiliated to Fujian Medical University, Fu’an, Fujian 355000, China
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THE INVESTIGATION OF ANTIMICROBIAL ACTIVITY OF SOME EXTRACTS FROM MOMORDICA CHARANTIA BY USING AS SOLVENT EXTRACTION AN IONIC LIQUID
CLAUDIA SIMONA ŞTEFAN 1*, CARMEN LIDIA CHIŢESCU 1, NICUȚA MANOLACHE 1, CAMELIA DIACONU 1, ALINA MIHAELA ELISEI 1, ADRIAN BEZNEA 1, ALINA VIORICA IANCU 1, GABRIELA GURĂU 1, ELENA ROXANA CHIRIAC 2, IULIU FULGA 1
1“Dunărea de Jos” University of Galați, Faculty of Medicine and Pharmacy, 35 Al. I. Cuza Street, Galați, Romania 2“Carol Davila” University of Medicine and Pharmacy of Bucharest, 8 Eroii Sanitari Boulevard, Bucharest, Romania
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STUDY REGARDING A NEW EXTENDED-RELEASE CALCIUM ASCORBATE AND HESPERIDIN SOLID ORAL FORMULATION
ANCA LUCIA POP 1#, PAULA HENTEȘ 2, MARIANA-ANA PALI 2, OȘANU LIANA 2, ANNEMARIE CIOBANU 1*, BOGDANA ADRIANA NASUI 3#, MAGDALENA MITITELU 1#, SIMONA CRIȘAN 2, OVIDIU NICOLAE PENEȘ 4
1Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020945, Bucharest, Romania 2R&D Centre, AC HELCOR, 430082, Baia Mare, Romania
3Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349, Cluj-Napoca, Romania
4Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 030167, Bucharest, Romania -
STANDARDIZATION OF ZIZIPHORA CLINOPODIOIDES LAM. CULTIVATED AND WILD GROWING IN THE SOUTH-CAUCASIAN FLORA
ULIKHANYAN GRETA 1,2*, TSATURYAN AVETIS 3, DUMANYAN KARINE 1, ALTUNYAN ASTGHIK 1, BEGLARYAN MARGARITA 4, HOVSEPYAN MAYA 5, CHICHOYAN NAIRA 1
1Yerevan State Medical University after M. Heratsi, Department of Pharmacognosy, Yerevan, Armenia,
2Yerevan State Medical University after M. Heratsi, Department of Medical Physics, Yerevan, Armenia,
3Scientific and Production Center «Armbiotechnology» National Academy of Sciences, RA, Yerevan, Armenia,
4Yerevan State Medical University after M. Heratsi, Department of Pharmaceutical Management, Yerevan, Armenia, 5Yerevan State Medical University after M. Heratsi, Department of Medical Biology, Yerevan, Armenia -
THE DIRECT COSTS BURDEN OF BEVACIZUMAB IN SOUTH-WEST ROMANIA
VALENTINA GHIMPĂU 1#, DANIEL SUR 2#, SIMONA RUXANDRA VOLOVĂȚ 3, IRINA MIHAELA CAZACU 4, VLAD MIHAI CROITORU 4, ADINA TURCU-ȘTIOLICĂ 5*, DAN IONUȚ GHEONEA 6, ADRIANA-ELENA TĂEREL 7#, MIHAELA-SIMONA SUBȚIRELU 5, CRISTIAN VIRGIL LUNGULESCU 8
1Doctoral School, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania
2Department of Medical Oncology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400015, Cluj-Napoca, Romania
3Department of Oncology, “Grigore T Popa” University of Medicine and Pharmacy, 700115, Iași, Romania
4Department of Medical Oncology, “Fundeni” Clinical Institute, 022328, Bucharest, Romania
5Department of Pharmacoeconomics, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania
6Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania 7Department of Pharmaceutical Management and Marketing, University of Medicine and Pharmacy “Carol Davila”, 020956,
Bucharest, Romania
8Department of Oncology, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania -
A STRUCTURED MEDICATION QUESTIONNAIRE TO EVALUATE THE CORRECTNESS OF THE MEDICATION ANAMNESIS
OCTAVIA SABIN 1*, AMALIA IOANA RADU 2, ANCA DANIELA FARCAȘ 3, ANCA DANA BUZOIANU 4
1Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
3Medicala I Department of Internal Medicine, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
4Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania