Romanian Society of Pharmaceutical Sciences

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ANTIBIOTIC RESISTANCE PHENOTYPES OF S. AUREUS ISOLATES FROM NOSE AND PHARYNX OF HEALTHY YOUNG ADULTS

ADRIAN ANTON BĂNCESCU 1, TEODORA MARIA IONESCU 2, GABRIELA BĂNCESCU 2*, CARMEN LILIANA DEFTA 2

1Department of Epidemiology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2Department of Microbiology, Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

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The aim of this work was to identify the antibiotic resistance phenotypes of S. aureus isolates from nose and pharynx in healthy adults represented by students at the Faculty of Dentistry, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania. The antimicrobial susceptibility investigation was performed by the Kirby-Bauer method and D-test on a collection of S. aureus strains isolated in 2017 from students in the second year of study. Discs with: penicillin G, cefoxitin, erythromycin, clindamycin, gentamicin, tetracycline, norfloxacin, trimethoprim-sulphamethoxazole and linezolid were used. In addition, the minimum inhibitory concentration of oxacillin was determined by E-test for all S. aureus strains with a growth inhibition area of less than 22mm in diameter around the cefoxitin disc. The 5 strains of methicillin-resistant S. aureus (MRSA) and more than half of the methicillin-sensitive S. aureus (MSSA) isolates showed inducible MLSB resistance phenotype and many of them were multidrug-resistant. The study underlines, that young adults in preclinical study years should be informed about the risk of the cross-infection with such bacteria.