THE INVESTIGATION OF ANTIMICROBIAL ACTIVITY OF SOME EXTRACTS FROM MOMORDICA CHARANTIA BY USING AS SOLVENT EXTRACTION AN IONIC LIQUID
CLAUDIA SIMONA ŞTEFAN 1*, CARMEN LIDIA CHIŢESCU 1, NICUȚA MANOLACHE 1, CAMELIA DIACONU 1, ALINA MIHAELA ELISEI 1, ADRIAN BEZNEA 1, ALINA VIORICA IANCU 1, GABRIELA GURĂU 1, ELENA ROXANA CHIRIAC 2, IULIU FULGA 1
1“Dunărea de Jos” University of Galați, Faculty of Medicine and Pharmacy, 35 Al. I. Cuza Street, Galați, Romania 2“Carol Davila” University of Medicine and Pharmacy of Bucharest, 8 Eroii Sanitari Boulevard, Bucharest, Romania
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The present study aimed to investigate the antimicrobial efficiency of an extract of Momordica charantia obtained by the sonication method, using an ionic liquid of pyrrolidinium hexanoate (PyrrHexa) as solvent extraction. The results were compared with those obtained by sonication for an extract based on ethanol (Et-OH 70°) and an extract based on ethanol: PyrrHexa (1:1) solvents mixture. The antimicrobial efficiency of ethanol and ionic liquid without vegetable mass was investigated. The results showed that PyrrHexa-based samples demonstrate a more significant antimicrobial potential than the common ethanol solvent. Also, the same variation of antimicrobial efficiency of the analysed extracts was observed for all the strains: alcoholic extract < ethanol: PyrrHexa (1:1) mixture extract < PyrrHexa extract. An efficiency 3.3 times higher than Nystatin 100 IU was demonstrated in the case of Candida albicans strain for both PyrrHexa based extract and PyrrHexa solvent without adding vegetal mass.