INFLUENCE OF DEXMEDETOMIDINE ON CLINICAL EFFICACY OF GENERAL ANESTHESIA AND STRESS RESPONSE IN CHILDREN
YAGUI LIANG, JINQIANG YUAN*, DIGUI WENG, QINGQING HUANG, SANYING CAI, JINGPING ZHAN
Department of Anaesthesiology, The Mindong Hospital Affiliated to Fujian Medical University, Fu’an, Fujian 355000, China
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This study was aimed to explore the effect of dexmedetomidine (DEX) nose drops on paediatric general anaesthesia in the resuscitation room and its influence on children's postoperative stress. Sixty-eight children undergoing general anaesthesia were enrolled. They were randomly divided into two groups according to admission, with 34 cases in each group. Children in the experimental group received DEX at a 1µg/kg dose as nasal drops, combined with sevoflurane (SEV) anaesthesia. Children in the control group received 0.4 mL saline as nasal drops, combined with SEV anaesthesia. Mean arterial pressure (MAP) and heart rate (HR) were recorded before induction of anaesthesia (T0), during extubation (T1), 5 min (T2), and 15 min after extubation (T3). In addition, venous blood was sampled at each of the above time points to determine the plasma epinephrine (E), norepinephrine (NE), and cortisol (Cor) levels to evaluate the postoperative stress response. The incidence of adverse reactions in the two groups was counted. The rate of crying at T1, restlessness after awakening, and adverse reactions were significantly reduced in children from the experimental group compared with the control group. The induction time of anaesthesia in children in the experimental group was significantly decreased compared with the control group. There was no considerable difference in the awakening time of the two groups of children, and the stay time in the post-anaesthesia care unit (PACU) was not extended. In addition, the children in the experimental group had lower MAP and HR at the time of extubation and 5 minutes after extubation compared with the control group. At T1 and T2, the changes of plasma E, NE, and Cor in children from the experimental group were significantly decreased compared with the levels in the control group.
