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EFFECTS OF CHLOROGENIC ACID ON BEHAVIOR AND METABOLISM IN OVARIECTOMIZED RATS

ANTOANETA GEORGIEVA 1*, MILENA TODOROVA 1, MIROSLAV EFTIMOV 1, VASILENA KUZMANOVA 2, ATANAS KUZMANOV 2, KRASIMIR KUZMANOV 3, MILA VLASKOVSKA 4, STEFKA VALCHEVA-KUZMANOVA 1

1Department of Pharmacology and Clinical Pharmacology and Therapeutics, Medical University “Prof. Dr. Paraskev
Stoyanov”, Varna, Bulgaria
2Medical University “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
3Vivarium, Medical University “Prof. Dr. Paraskev Stoyanov”, Varna, Bulgaria
4Department of Pharmacology and Toxicology, Medical University, Sofia, Bulgaria

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The objective of the present study was to make a complex evaluation of the effect of chlorogenic acid (CGA) on behaviour, lipid metabolism and bone mineral density (BMD) in an ovariectomized (OVX) rat model. Female Wistar rats were divided in 3 groups, each of 14 animals – sham operated (SO), OVX and the last group ovariectomized rats treated with CGA. Three months after the operation, rat behaviour was investigated in the open field test (OFT), elevated plus-maze test (EPM), social interaction test (SIT), forced swimming test (FST) and hot plate test (HPT). Weight gain, total and retroperitoneal fat deposits were measured, as well as serum concentrations of total cholesterol. Femur BMD was also evaluated. CGA managed to improve some of the negative consequences of the oestrogen deficit (anxiety and depressive behaviour, increased pain sensitivity and decreased BMD) and did not affect others (increased fat accumulation and elevated cholesterol levels).