Farmacia Journal 5/2021
Volume 69 | Number 5 | Year 2021
Download this issue’s covers and announcements.
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HETEROCYCLES 49. SYNTHESIS, CHEMICAL BEHAVIOUR AND BIOLOGICAL PROPERTIES OF HETEROCYCLIC CHALCONES. REVIEW FROM OUR RESEARCH
DENISA LEONTE 1, FANA-MARIA COMAN 1, GHISLAIN W. FOTSO 2, BONAVENTURE T. NGADJUI 2,3, VALENTIN ZAHARIA 1*, BATHELEMY NGAMENI 3
1Department of Organic Chemistry, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca 41 Victor Babeş
Street, RO-400012, Romania
2 Department of Organic Chemistry, University of Yaounde I, Yaounde, P.O. Box 812, Cameroon
3 Department of Pharmacognosy and Pharmaceutical Chemistry, University of Yaounde I, Yaounde, P.O. Box 1364, Cameroon -
A PARADIGM SHIFT FOR THE SGLT2 INHIBITORS – TREATING THE HEART WITH ANTI-HYPERGLYCAEMIC DRUGS
ELISABETA BĂDILĂ 1,2, ANA-MARIA BALAHURA 1,2*, MARILENA STOIAN 1,3, DANIELA
BARTOȘ 1,2, DRAGOȘ VINEREANU 1,41Department of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021,
Bucharest, Romania
2 Department of Internal Medicine, Clinical Emergency Hospital Bucharest, 8 Floreasca Street, 014461, Bucharest, Romania
3 Department of Internal Medicine, “Dr. I. Cantacuzino” Clinical Hospital, 5-7 Ion Movilă Street, 030167, Bucharest, Romania
4 Department of Cardiology, University and Emergency Hospital, 169 Splaiul Independenței, 050098, Bucharest, Romania -
IN VITRO ANTIMICROBIAL, ANTIBIOFILM AND CYTOTOXIC ACTIVITIES OF THE EXTRACTS OF ARUM ITALICUM MILLER LEAVES
MAYRAM HACIOGLU 1, BUSRA KULAKSIZ 2, KERIM ALPINAR 3, EBRU HACIOSMANOGLU 4, A. SEHER BIRTEKSOZ TAN 1*
1Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey
2 Department of Pharmacognosy, Faculty of Pharmacy, Biruni University, Zeytinburnu, Istanbul, 34010, Turkey
3 Department of Pharmaceutical Botany, Faculty of Pharmacy, Biruni University, Zeytinburnu, Istanbul, 34010, Turkey
4 Department of Biophysics, Faculty of Medicine, Bezmialem Vakıf University, Fatih, İstanbul, 34093, Turkey -
IDENTIFICATION AND QUANTIFICATION OF RISK FACTORS RELATED TO THE QUALITY OF LIFE OF MULTIPLE SCLEROSIS PATIENTS
SIMONA OPREA 1, ANDREI VĂLEANU 2*, SIMONA NEGREȘ 2
1Bucharest Emergency University Hospital, 169 Splaiul Independenței, 050098 Bucharest, Romania
2 ”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania -
COMPARATIVE CHEMICAL AND BIOLOGICAL ACTIVITY OF SELECTIVE HERBAL EXTRACTS
IOANA HUMULESCU 1#, MIHAELA-MAGDALENA FLUTUR 1, OANA CIOANCĂ 1*, CORNELIA
MIRCEA 1, SILVIA ROBU 2#, DENISA MARIN-BATIR 2#, ADRIAN SPAC 1, ANDREIA CORCIOVA 1, MONICA HĂNCIANU 11Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iași, 700115 Iași, Romania
2 Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800010 Galați, Romania -
IMPLEMENTATION OF EXPERIMENTAL DESIGN METHODOLOGY IN THE COMPATIBILITY STUDY OF HYDROCORTISONE WITH SELECTED EXCIPIENTS USED IN SOLID DOSAGE FORMS
JOANNA RONOWICZ-PILARCZYK 1*
1Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, ul. Jurasza 2, 85-089 Bydgoszcz, Poland
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THE FREQUENCY OF VITAMIN B12 DEFICIENCY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS TREATED WITH METFORMIN FOR AT LEAST FIVE YEARS
ELENA CRISTINA CRĂCIUN 1#*, DANIEL CORNELIU LEUCUŢA 2#, SIMINA FELICIA
ŢĂRMURE 3#, ILINCA COPCEA 4, ADRIAN COPCEA 5, RODICA ANA UNGUR 6, IOANA PARA 31Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, „Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
2 Department of Medical Informatics and Biostatistics, Faculty of Medicine, „Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
3 Department of Internal Medicine 4th Medical Clinic, Faculty of Medicine, „Iuliu Haţieganu” University of Medicine and
Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
4 Clinical Center for Diabetes, Nutrition and Metabolic Diseases, 2 Clinicilor Street, 400006, Cluj-Napoca, Romania
5 Asteco Medical Center, 105 Constantin Brâncuşi Street, 400458, Cluj-Napoca, Romania
6 Department of Medical Specialties, Faculty of Medicine, “Iuliu Haţieganu" University of Medicine and Pharmacy, 8 Victor
Babeș Street, 400012, Cluj-Napoca, Romania -
EVALUATION OF THE CYTOTOXIC EFFECTS INDUCED BY 68Ga-NODAGA-c(RGDfK) AND 68Ga-DOTA-c(RGDfK) IN MURINE MALIGNANT MELANOMA
MARIETA ELENA PANAIT 1#, MARIA IULIANA GRUIA 1, ANTONELA BUȘCĂ 1*, MARIAN AUGUSTIN MARINCAȘ 1,2#
1Institute of Oncology Prof. Dr. Al. Trestioreanu, 252 Fundeni Street, 022328, Bucharest, Romania
2 “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021, Bucharest, Romania -
CHEMICAL COMPOSITION, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF PHYTOLACCA AMERICANA L. FRUITS AND LEAVES EXTRACTS
IOANA CRISTINA MARINAŞ 1,2, ELIZA OPREA 3*, ELISABETA-IRINA GEANĂ 4, CRISTINA
MIHAELA LUNTRARU 5, CERASELA ELENA GÎRD 6, MARIANA-CARMEN CHIFIRIUC 1,71Research Institute of the University of Bucharest-ICUB, 91-95 Spl. Independentei, Bucharest, Romania University of
Bucharest and Faculty of Biology, Microbiology Department, 1-3 Portocalilor Way, 060101, Bucharest, Romania
2 National Institute of Research and Development for Food Bioresources – IBA Bucharest, 6 Dinu Vintila Street, 021102, Bucharest, Romania
3 University of Bucharest, Faculty of Chemistry, Department of Organic Chemistry, Biochemistry and Catalysis, 4-12 Regina Elisabeta, 030018 Bucharest, Romania
4 National Research and Development Institute for Cryogenics and Isotopic Technologies – ICIT Rm. Valcea, 4 Uzinei Street, PO Raureni, 240050 Râmnicu Valcea, Romania
5 S.C. Hofigal Export Import S.A., Research Development Patents Department, no. 2 Intrarea Serelor Street, district 4, Bucharest, Romania
6 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
7 Academy of Romanian Scientists, Bucharest, Romania -
THE THERAPEUTIC EFFECT OF HUANGLIAN JIEDU DECOCTION ON ALZHEIMER’S DISEASE BY REGULATING PHAGOCYTOSIS INDUCED BY Aβ IN BV-2 MICROGLIAL CELLS
JUNLI WANG #, WEI SHAO #, YUN YANG, WEIDONG LUO, GUOHUA CHEN *
Department of Neurology, Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan First Hospital), Wuhan,
43 0022, Hubei, China -
THE BENEFIT OF ENTROPY IN THE MANAGEMENT OF GENERAL ANAESTHESIA FOR THE PATIENTS WITH METABOLIC DISORDERS
CĂLIN TIMAR 1,2#, PETRE COTRAU 1,2, CRISTIAN DAINA 1,2, RALUCA JUNCAR 2, ALIN
TEUȘDEA 3*, LAURA VICAȘ 2, ELEONORA MARIAN 2#, ANDREEA MARGARETA VLAD 2, MIHAI JUNCAR 21Emergency County Hospital Oradea, Department of Anaesthesia and Intensive Care (ATI1), 65-67 Gheorghe Doja Street, Oradea, Romania
2 Faculty of Medicine and Pharmacy, University of Oradea, 10 Decembrie Square, Oradea, Romania
3 Faculty of Environmental Protection, University of Oradea, 23 Gen. Magheru Street, Oradea, Romania -
MIMOSA TENUIFLORA FOR THE TREATMENT OF DAMAGED SKIN – STUDY ON ITS EFFICACY AND TOLERABILITY IN THE TREATMENT OF IRRITATIVE CONTACT DERMATITIS
ALIN CODRUȚ NICOLESCU 1#, ANCA CECILIA NICOARĂ 2*, SÎNZIANA IONESCU 2,3#,
LAURENȚIU SIMION 2,3, MARIA MAGDALENA CONSTANTIN 2,4#, ȘTEFANA BUCUR 2,4,
IOAN ANCUȚA 2,51Roma Medical Center for Diagnosis and Treatment, 32-34 Roma Street, Bucharest, 011773, Romania
2 “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, Bucharest, 050474, Romania
3 Surgery Department I, “Prof. Dr. Al. Trestioreanu”, Oncology Institute Bucharest, 252 Soseaua Fundeni, Bucharest, 022328, Romania
4 Dermatology Department II, Colentina Clinical Hospital, Soseaua Stefan cel Mare 19-21, Bucharest, Romania 5Department of Rheumatology, “Dr. I. Cantacuzino” Clinical Hospital, Ioan Movila Street, nr. 5-7, Bucharest, 020475, Romania -
INVESTIGATION OF CLASS 1 INTEGRONS WITH ANTIBIOTIC RESISTANCE GENES IN MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII STRAINS AND DETERMINATION OF PLANT EXTRACT EFFECTS ON MULTIDRUG-RESISTANT ISOLATES
AYŞEGÜL SARAL 1, SEDANUR CINEMRE 2, FUNDA OKUMUŞ 2, ZEYNEP AKAR 3, AYŞEGÜL ÇOPUR ÇIÇEK 4, AZER ÖZAD DÜZGÜN 3*
1Department of Nutrition and Dietetics, Faculty of Health Sciences, Artvin Coruh University, Artvin, Turkey
2 Department of Biotechnology, Institute of Natural Sciences, Gumushane University, Gümüşhane, Turkey
3 Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, Gumushane University,
Gümüşhane, Turkey
4 Recep Tayyip Erdoğan University, Faculty of Medicine, Department of Medical Microbiology, Rize, Turkey -
ORAL ANTIPLATELET THERAPY IN ACUTE CORONARY SYNDROMES, CLINICAL EXPERIENCE IN AN EMERGENCY HOSPITAL WITH PERCUTANEOUS CORONARY INTERVENTION FACILITIES
ELENA EMILIA BABEŞ 1,2, VICTOR VLAD BABEŞ 1,2*, DIANA LUCUŢA 1, ILYES CRISTIAN 1, MIRCEA IOACHIM POPESCU 1,2, OTILIA ŢICA 1,2
1 Emergency County Clinical Hospital Oradea, Cardiology Clinic, 65 Gh. Doja Street, Oradea, Romania
2 Faculty of Medicine and Pharmacy, University of Oradea, 10 1st of December Square, Oradea, Romania -
COMPARATIVE PHYTOCHEMICAL EVALUATION IN SEVERAL ACHILLEA SPECIES FROM ROMANIA
MIHAELA POPOVICI 1, GHEORGHE COLDEA 2, ANA COSTE 2*, CARMEN POP 1, MIRCEA
TĂMAȘ 11Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Haţieganu”, 12 I. Creangă Street, 400010, Cluj-Napoca,
Romania
2 Institute of Biological Research Cluj-Napoca, branch of NIRDBS, 48 Republicii Street, 400015, Cluj-Napoca, Romania -
EVALUATION OF THE BIOCOMPATIBILITY OF LASER IRRADIATED PLANT EXTRACTS USED AS ADJUVANTS IN IRRIGATION AND SANITIZATION OF ROOT CANALS
ANDREI VASILACHE 1#, MARCELA POPA 2#, CRISTINA-CRENGUȚA ALBU 3*, ANCA-OANA DRAGOMIRESCU 1, ADRIANA VASILACHE 1#, MARIA-ANGELICA BENCZE 1, IOANA SUCIU 4, ECATERINA IONESCU 1
1Department of Orthodontics and Dentofacial Orthopaedics, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania
2 Research Institute of the University of Bucharest – ICUB, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
3 Department of Genetics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania
4 Departments of Endodontics, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 37
Dionisie Lupu Street, 020021 Bucharest, Romania -
DETERMINATION AND COMPARISON OF FATTY ACIDS COMPOSITION OF APRICOT AND PEACH OILS
LESIA SAVCHENKO 1*, LIUDAS IVANAUSKAS 2, LAURYNAS JARUKAS 2, VICTORIYA GEORGIYANTS 3
1Department of Quality, Standardization and Certification of Medicines, Institute of Pharmacy Professionals Qualification
Improvement, National University of Pharmacy, 17 Zahysnynykiv Ukrainy Sqaure, 61001, Kharkiv, Ukraine
2 Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, 9 A. Mickevičiaus Street,
44 307, Kaunas, Lithuania
3 Department of Pharmaceutical Chemistry, National University of Pharmacy, 4 Valentynivska Street, 61000, Kharkiv, Ukraine -
CHITOSAN SUPPORTS CONTAINING IMPATIENS NOLI-TANGERE AND SYMPHYTUM OFFICINALE HYDROALCOHOLIC EXTRACTS IN BURNS TREATMENT: ANTIMICROBIAL AND HEALING EFFECTS
ANCA ZANFIRESCU 1, CRISTINA DANIELA MARINECI 1*, GABRIELA PĂUN 2, OANA
UNGUREANU 2, ELENA NEAGU 2, CORNEL CHIRIȚĂ 1, BRUNO ȘTEFAN VELESCU 1,
OCTAVIAN TUDOREL OLARU 1, SIMONA NEGREȘ 11Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 National Institute for Research-Development of Biological Sciences, Bucharest, Romania -
PRELIMINARY RESEARCH REGARDING CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY EFFECTS OF POLYGONUM PLEBEIUM R. BR
HASEEB AHSAN 1*, MUHAMMAD NAVEED MUSHTAQ 2, IRFAN ANJUM 2, MUHAMMAD FIAZ 3, AHMED RAZA CHEEMA 4, SYED IHTISHAM HAIDER 5, GEBRETSADKAN HINTSA TEKULU 6
1Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Pakistan
2 Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Pakistan
3 Faculty of Pharmacy and alternative medicine, The Islamia University of Bahawalpur, Pakistan
4 Department of Economics, Faculty of Social Sciences, University of Sargodha, Pakistan
5 Department of Pharmacology, Nawaz Sharif Medical College, University of Gujrat, Pakistan
6 Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, P.O. Box 1871,
Mekelle, Ethiopia -
DETERMINATION OF ARYLTETRALIN-LIGNANS AND BIOACTIVITY SCREENING OF LINUM ARBOREUM L. FROM TURKEY
ZAHER SULTAN 1, HAJAR HEYDARI 1, ASLI KOC 2, ABDURRAHMAN AYGUL 3, BELMA KONUKLUGIL 4*
1Pharmacognosy Department, Pharmacy Faculty, Ankara University, Tandoğan, 06100 Ankara, Turkey
2 Biochemistry Department, Pharmacy Faculty, Ankara University, Tandoğan, 06100 Ankara, Turkey
3 Pharmaceutical Microbiology Department, Pharmacy Faculty, Cukurova University, Sarıçam, 01330 Adana, Turkey
4 Pharmacognosy Department, Faculty of Pharmacy, Lokman Hekim University, Söğütözü, 06510 Çankaya, Ankara, Turkey -
ANTICANCER ACTIVITY OF DIPHENHYDRAMINE AGAINST PANCREATIC CANCER BY STIMULATING CELL CYCLE ARREST, APOPTOSIS, AND MODULATION OF PI3K/Akt/mTOR PATHWAY
RUI ZHANG 1, MIN CHEN 2, LEI YU 1, ZHAOHUI JIN 1*
1Department of Pharmacy, West China Hospital, Sichuan University, 610041, Chengdu, China
2 Department of Gastroenterology, West China Hospital, Sichuan University, 610041, Chengdu, China -
EVALUATION OF BIOLOGICAL ACTIVITIES OF ACETONE EXTRACT OF THE MUSHROOM LECCINUM SCABRUM
JOVANA TUBIĆ VUKAJLOVIĆ 1, MARIJANA KOSANIĆ 1, BRANISLAV RANKOVIĆ 1,
TATJANA STANOJKOVIĆ 2, ALEKSANDRA MARKOVIĆ 1, DARKO GRUJIČIĆ 1, NINOSLAV
DJELIĆ 3, MILENA RADAKOVIĆ 3, OLIVERA MILOŠEVIĆ-DJORDJEVIĆ 1,4*1University of Kragujevac, Faculty of Science, Department of Biology and Ecology, 34000 Kragujevac, Serbia
2 Institute of Oncology and Radiology of Serbia, 11000 Belgrade, Serbia
3 University of Belgrade, Faculty of Veterinary Medicine, 11000 Belgrade, Serbia
4 University of Kragujevac, Faculty of Medical Sciences, Department of Genetics, 34000 Kragujevac, Serbia -
PRESCRIPTION DRUG (RX) EVOLUTION IN ROMANIA BETWEEN 2010 AND 2020
PETRU CRĂCIUN 1, MARIAN PANĂ 1*, DUMITRU LUPULIASA 1, MARIA-DORINA CRĂCIUN 2,
ADRIANA-ELENA TĂEREL 31Pharmaceutical Technology and Biopharmacy Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 Department of Epidemiology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3 Department of Pharmaceutical Management and Marketing, Faculty of Pharmacy, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania -
OPINIONS ABOUT COMMUNITY PHARMACY-BASED HEALTH SCREENINGS FROM PATIENTS’ LIVING IN RIYADH (SAUDI ARABIA), POZNAN (POLAND) AND CHICAGO (UNITED STATES OF AMERICA)
MAGDALENA WASZYK-NOWACZYK 1*, WERONIKA GUZENDA 1, SAIF ALKATHIRI 2, ANNA RATKA 3
1Department of Pharmaceutical Technology, Pharmacy Practice Division, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland
2 Prince Sultan Military Medical City, Makkah road. Al Sulimaniyah, Riyadh, Saudi Arabia
3 Wegmans School of Pharmacy, St. John Fisher College, 3690 East Avenue, Rochester, NY 14618, United States of America -
FACTORS THAT INFLUENCE THE CAREER PATH AND CAREER SATISFACTION OF A PHARMACY GRADUATE IN ROMANIA
DRAGOȘ FLORIAN CIOLAN 1, CĂTĂLINA LILIANA ANDREI 2*, ANDREEA MIRICĂ 3,
IONELA ROXANA GLĂVAN 3 , DOINA DRĂGĂNESCU 4, DUMITRU LUPULIASA 1, RĂZVAN
MIHAI DOBRESCU 5, FLAVIAN ȘTEFAN RĂDULESCU 11“Carol Davila” University of Medicine and Pharmacy, Centre for Drug Sciences (CedS), Bucharest, Romania
2 “Carol Davila” University of Medicine and Pharmacy, Department of Cardiology and Thoracic Pathology, Bucharest,
Romania
3 Bucharest University of Economic Studies, Faculty of Economic Cybernetics, Statistics and Informatics, Statistics and Econometrics Department, Bucharest, Romania
4 “Carol Davila” University of Medicine and Pharmacy, Department of Pharmaceutical Physics and Informatics, Bucharest,
Romania
5 University Politehnica of Bucharest, Faculty of Entrepreneurship, Business Engineering and Management, Economics Department, Bucharest, Romania