Romanian Society of Pharmaceutical Sciences

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CHITOSAN SUPPORTS CONTAINING IMPATIENS NOLI-TANGERE AND SYMPHYTUM OFFICINALE HYDROALCOHOLIC EXTRACTS IN BURNS TREATMENT: ANTIMICROBIAL AND HEALING EFFECTS

ANCA ZANFIRESCU 1, CRISTINA DANIELA MARINECI 1*, GABRIELA PĂUN 2, OANA
UNGUREANU 2, ELENA NEAGU 2, CORNEL CHIRIȚĂ 1, BRUNO ȘTEFAN VELESCU 1,
OCTAVIAN TUDOREL OLARU 1, SIMONA NEGREȘ 1

1Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2National Institute for Research-Development of Biological Sciences, Bucharest, Romania

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Burn injuries have a major impact on population health, an optimal burn wound dressing with both healing and antibacterial effect being needed. Our purpose was to assess the healing efficacy of chitosan supports containing different quantities of a hydroalcoholic extract obtained from Impatiens noli-tangere and Symphytum officinale, in a rat burn wound model. The antibacterial effect of the extract was also assessed. The efficacy of topical daily administration of the supports and of silver sulphadiazine was evaluated by measuring the thermal lesion area. In addition, tissular hydroxyproline content and IL-6, TNF-alpha plasmatic levels were measured. The chitosan support with the highest content of plant extract showed the most pronounced healing effect. The mixed extract was shown to possess a moderate antibacterial effect, the most sensitive microorganism being S. aureus.