Romanian Society of Pharmaceutical Sciences
 

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HETEROCYCLES 49. SYNTHESIS, CHEMICAL BEHAVIOUR AND BIOLOGICAL PROPERTIES OF HETEROCYCLIC CHALCONES. REVIEW FROM OUR RESEARCH

DENISA LEONTE 1, FANA-MARIA COMAN 1, GHISLAIN W. FOTSO 2, BONAVENTURE T. NGADJUI 2,3, VALENTIN ZAHARIA 1*, BATHELEMY NGAMENI 3

1Department of Organic Chemistry, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca 41 Victor Babeş
Street, RO-400012, Romania
2Department of Organic Chemistry, University of Yaounde I, Yaounde, P.O. Box 812, Cameroon
3Department of Pharmacognosy and Pharmaceutical Chemistry, University of Yaounde I, Yaounde, P.O. Box 1364, Cameroon

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The synthesis of the natural products analogues has performed a remarkable expansion in recent years, as natural structures have inspired researchers to develop new potential therapeutic agents with improved pharmacological and pharmacokinetic profiles. This review provides an overview on the synthesis, chemical behaviour and biological properties of some already synthesized heterocyclic chalcones bearing thiazole, indole and pyridine moieties. The attention is directed to the reactivity of the α,β-unsaturated ketone system which provides access to new heterocyclic compounds. The structures of chalcones and their cyclisation products that have shown encouraging in vitro antitumour and antifungal properties are highlighted.