Farmacia Journal 2/2024
Volume 72 | Number 2 | Year 2024
Download this issue’s covers, and announcements.
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MODIFIED RELEASE OF SOFT GELATINE CAPSULES DELIVERY SYSTEMS
PUTRIANA RACHMAWATI 1*, TRI SUCIATI 2, SATRIALDI 2
1Department of Pharmacy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
2School of Pharmacy, Institut Teknologi Bandung -
NATURAL SUNSCREENS – A LITERATURE REVIEW
MIHAELA AFRODITA DAN 1, EMMA ADRIANA OZON 1, MARILENA VIORICA HOVANEȚ 2*, HORAȚIU-MARIUS VIZITEU 1, MIRELA ADRIANA MITU 1, VIOLETA POPOVICI 3, DUMITRU LUPULIASA 1, IOANA ANDREEA POPESCU 1
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, 6 Traian Vuia Street, 020945, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Botany, 6 Traian Vuia Street, 020945, Bucharest, Romania
3“Costin C. Kiriţescu” National Institute of Economic Research - Centre for Mountain Economics (INCE-CEMONT), Romanian Academy, 725700, Vatra-Dornei, Romania -
A REVIEW OF ABDOMINAL AORTIC ANEURYSMS: RISK FACTORS, SCREENING, PHARMACOLOGICAL APPROACH
DIDUTA ALINA BRIE 1,2, ADELINA MARIA JIANU 3, ROXANA POPESCU 1,2, TAMARA MARCELA MARCOVICI 4,5, IOANA MUNTEAN 1,2, DANIELA PUSCASIU 1,2, MIHAI MITULETU 1,2, DANIEL MIRON BRIE 6*, MADALINA BORUGA 7
1Department of Cellular and Molecular Biology, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
2ANAPATMOL Research Centre, “Victor Babeş” University of Medicine and Pharmacy of Timişoara, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
3Department of Anatomy and Embryology, “Victor Babeş” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timişoara, Romania
4Clinical Section I Paediatrics-Nutritional Recovery, “Louis Turcanu” Children's Emergency Hospital, 300011, Timişoara, Romania
5Department XI Paediatrics, Discipline I Paediatrics, “Victor Babeş” University of Medicine and Pharmacy of Timişoara, 300041, Timişoara, Romania
6Department of Interventional Cardiology, Cardiovascular Disease Institute Timişoara, 13A Gheorghe Adam Street, 300310, Timişoara, Romania
7Department of Toxicology and Drug Industry, “Victor Babeș” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041, Timişoara, Romania -
TICAGRELOR – MECHANISM OF ACTION AND ITS IMPACT ON DRUG EFFICACY
LOREDANA-MARIA MARIN 1*, IULIAN SÎRBU 2, EMMA-ADRIANA OZON 3, MARCIN SKOTNICKI 4, JANINA LULEK 4, RĂZVAN DANIEL CHIVU 5, DOINA DRĂGĂNESCU 1
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Physics, 020956 Bucharest, Romania
2Zentiva S.A., 032266 Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, 020956 Bucharest, Romania
4Poznan University of Medical Sciences, Faculty of Pharmacy, Department of Pharmaceutical Technology, Industrial Pharmacy Division, 60-806 Poznan, Poland
5“Carol Davila” University of Medicine and Pharmacy, Faculty of Midwifery and Nursing, 050474 Bucharest, Romania -
AN UPDATED REVIEW ON CHEMICAL, BIOLOGICAL AND PHARMACOLOGICAL ATTRIBUTES OF DEINOXANTHIN
RANA KOLAHI AHARI 1, TOKTAM SAHRANAVARD 1, ARISTIDIS TSATSAKIS 2,3, ANDREEA LETIȚIA ARSENE 4, MARINA IONELA NEDEA (ILIE) 4, ALEXANDER E. NOSYREV 3, SEYEDEH FAEZEH TAGHIZADEH 5, RAMIN REZAEE 1,6*
1International UNESCO Centre for Health-Related Basic Sciences and Human Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Laboratory of Toxicology, Medical School, University of Crete, Heraklion, Crete, Greece
3Sechenov First Moscow State Medical University, 119991 Moscow, Russian Federation
4Department of General and Pharmaceutical Microbiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956, Bucharest, Romania
5Department of Horticultural Sciences, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
6Applied Biomedical Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran -
THE RELATIONSHIP BETWEEN STATIN THERAPY AND AGE- RELATED MACULAR DEGENERATION – A SYSTEMATIC REVIEW
ANA MARIA DASCALU 1#, CRISTINA ALEXANDRESCU 1, GETA VANCEA 1#, DANIELA STANA 2, DANIEL OVIDIU COSTEA 3*, ANCA ZGURA 1#, DRAGOS SERBAN 1, DAN DUMITRESCU 1, MIHAIL SILVIU TUDOSIE 1, CRENGUTA SORINA SERBOIU 1, LAURA CARINA TRIBUS 4, CORNELIU TUDOR 1, DAN GEORGIAN BRATU 5, CATALIN ALIUS 1, IRINA SHEVCHENKO 1, BOGDAN MIHAI CRISTEA 1
1Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania
2Ophthalmology Department, Emergency University Hospital Bucharest, Romania
3Faculty of Medicine, “Ovidius” University Constanța, Romania
4Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania
5Faculty of Medicine, “Lucian Blaga” University Sibiu, Romania -
EFFECT OF LOW MOLECULAR WEIGHT HEPARIN IN THE PREVENTION OF SEVERE PNEUMONIA COMPLICATED WITH LOWER EXTREMITY DEEP VEIN THROMBOSIS
KE XU, HUA LI, XIU YANG, YAN ZHANG, GUANGRONG YE, GE ZHANG, JUAN YAN, JIABING PENG, TAO LU *
Department of Critical Care Medicine, The First People’s Hospital of Longquanyi District, Chengdou, 610100, Sichuan, China
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EFFECTS OF SELECTIVE AND NON-SELECTIVE SODIUM CHANNEL BLOCKERS ON RAT PAIN SENSITIVITY
AURELIA MÂRZA 1 , CĂTALIN CEZAR CARĂTAȘU 1 , VERONICA BILD 1*, BOGDAN IONEL TAMBA 1,2 , WALTHER BILD 1
1“Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania
2Advanced Centre for Research and Development in Experimental Medicine, “Prof. Ostin C. Mungiu”, CEMEX, “Grigore T. Popa” University of Medicine and Pharmacy, Iași, Romania -
IN VIVO EVALUATION OF THE EFFECTS INDUCED BY HAWTHORN (CRATAEGI SP.) EXTRACT IN RATS, IN TWO EXPERIMENTAL DIET MODELS
ELENA IULIANA ILIE (IONIȚĂ) 1, OCTAVIAN TUDOREL OLARU 1, MARIA TEODORA PIȚURU 1,2, ANA CORINA POGAN 1, ELENA MOROȘAN 1, ANDREI VĂLEANU 1, ALEXANDRU RADU CORBU 3, ADRIANA ELENA NICA 4*, DANA ANTONIA ȚĂPOI 5, MARIA DANIELA TĂNĂSESCU 6,7, ALEXANDRU MINCĂ 6, CERASELA ELENA GÎRD 1
1Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
2Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, 105 Splaiul Independentei Boulevard, 050097, Bucharest, Romania
3Department of Horticulture & Food Science, University of Craiova, 13 AI Cuza Street, 200585, Craiova, Romania
4Department of Anaesthesiology and Intensive Care, University Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania
5Department of Pathology, University Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania
6Department of Medical Semiology, Discipline of Internal Medicine I and Nephrology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania
7Department of Nephrology, Bucharest Emergency University Hospital, 169 Splaiul Independenței Street, 050098, Bucharest, Romania -
ANTIBIOTICS IN PAEDIATRICS. A QUESTIONNAIRE-BASED SURVEY REGARDING BASIC MEDICAL KNOWLEDGE AND PARENTS’ ATTITUDES
BIANCA-EUGENIA ŐSZ 1, CAMIL-EUGEN VARI 1*, MONICA SEBESTYEN 1, AMELIA TERO- VESCAN 2, RUXANDRA ȘTEFĂNESCU 3
1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139, Târgu Mureș, Romania
2Department of Biochemistry, Faculty of Medicine, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540139, Târgu Mureș, Romania
3Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu-Mureș, 540139, Târgu Mureș, Romania -
THE ROLE OF MICROSTRUCTURAL TESTING IN THE ASSESSMENT OF THE IN VITRO RELEASE PROFILES FROM TOPICAL SEMISOLID FORMULATIONS
HORAȚIU-MARIUS VIZITEU, DALIA-SIMONA MIRON *, DUMITRU LUPULIASA, FLAVIAN-ȘTEFAN RĂDULESCU
Centre for Drug Sciences, Biopharmaceutics Laboratory, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy Bucharest, 6 Traian Vuia Street, 020956, Bucharest, Romania
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LC-MS ANALYSIS AND ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE INVESTIGATIONS OF LEUCAENA LEUCOCEPHALA FLOWERS GROWING IN JORDAN EXTRACTS
ALI MUHARRIF KHALID 1, ASMA ISMAIL MAHMOD 2, WAMIDH H. TALIB 2, FATMA U. AFIFI 1*
1Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Science Private University, Amman 11931-166, Jordan
2Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931-166, Jordan -
SYNTHESIS AND BIOACTIVITY OF A NOVEL DANDELION-LIKE SELENIUM AND CATECHIN COMPLEX
IONUȚ IULIAN LUNGU, CORNELIA MIRCEA, ALINA ȘTEFANACHE, FLORINA CRIVOI, OANA CIOANCĂ *, MONICA HĂNCIANU
“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Iași, Romania
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EFFECTS OF ANACYCLUS PYRETHRUM RADIX EXTRACT ON BEHAVIOURAL DISORDERS AND ACTIVATION OF MICROGLIA IN DEPRESSIVE RATS VIA TLR4/MYD88/NF-ΚB SIGNALLING PATHWAY
YONGHUA QI, DI WU *, CONG WANG
College of Jiamusi, Heilongjiang University of Chinese Medicine, Jiamusi, 154007, China.
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PRE-FORMULATION, FORMULATION AND PILOT SCALE-UP STUDIES TO ESTABLISH THE QUALITATIVE AND QUANTITATIVE COMPOSITION OF AN INNOVATIVE NANOFORM DIETARY SUPPLEMENT FOR MENOPAUSAL THERAPY
SIMONA CRISAN 1,2#, ANCA LUCIA POP 1#, PAULA HENTES 2, IOANA LACATUSU 3, NICOLETA BADEA 3, CORALIA ZETU 4*, ANNE MARIE CIOBANU 1, OVIDIU NICOLAE PENES 4#, VARLAS VALENTIN 4, EMMA ADRIANA OZON 1, DENISA IOANA UDEANU 1
1Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945, Bucharest, Romania
2R&D Centre, AC HELCOR, Victor Babes Street, 430082, Baia Mare, Romania
3Faculty of Applied Chemistry and Materials Science, The Polytechnic University of Bucharest, 1 Polizu Boulevard, 011061, Bucharest, Romania
4Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021, Bucharest Romania -
IN VITRO STUDY OF TOPICAL CAFFEINE AND ASCORBYL MAGNESIUM PHOSPHATE FORMULATIONS – PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND PHARMACO- TOXICOLOGICAL ASSESSMENT
ZAKZAK KHALED 1,2#, LAVINIA VLAIA 1,2#, ALEXANDRA DENISA SEMENESCU 1,3*, CRISTINA DUMITRESCU 1,3, GEORGETA CONEAC 1,2, ANDREEA MIHAELA KIS 1,3, ALINA MOACA 1,3, VICENTIU VLAIA 1, STELA IURCIUC 4, EUGEN HORATIU STEFANESCU 4
1Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
2Formulation and Technology of Drugs Research Centre, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
3Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
4Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania -
MULTIMODAL RESEARCH ON ANTIBIOTIC RESISTANCE OF PSEUDOMONAS AERUGINOSA STRAINS ISOLATED FROM PATIENTS WITH SEVERE BURNS IN ROMANIA
BOGDAN NIȚESCU 1,3, ANDREI ALEXANDRU MUNTEAN 1,2, BOGDAN PAVEL 1,3, LUCIA-ELENA IONESCU 2*, MARIUS NECȘULESCU 2, DANIELA PIȚIGOI 1,4, DANIELA TALAPAN 1,4, MIRCEA IOAN POPA 1,2, VICTORIA ARAMA 1,4
1Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 050474, Bucharest, Romania
2“Cantacuzino” National Institute for Research and Development in Military Medicine, 050096 Bucharest, Romania
3Hospital for Reconstructive Plastic Surgery and Burns, 010761, Bucharest, Romania
4“Prof. Dr. Matei Balș” National Institute for Infectious Diseases, 021105, Bucharest, Romania -
SYNTHESIS OF SORBITAN ESTERS OF JOJOBA OIL FATTY ACIDS AS SURFACTANTS: PHYSICOCHEMICAL CHARACTERIZATION AND OBTAINING SOLID DISPERSION OF IBUPROFEN TO ENHANCE DISSOLUTION
BASHAR ALTAANI 1*, RAZAN HADDAD 2, MOHHANAD KOSSA 1, QOSAY AL-BALAS 3, NASR ALRABADI 4
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan, 22110
2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jadara University, Irbid, Jordan, 21110
3Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan, 22110
4Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan, 22110 -
IN VITRO PROSPECTION OF ANTICANCER ACTIVITY OF SOME BROMINATED DERIVATIVES WITH ACETOPHENONE SCAFFOLD
ANA-MARIA ZBANCIOC *, ALEXANDRU VASINCU, ANCA MIRON, GABRIELA TATARINGA
1University of Medicine and Pharmacy “Grigore T. Popa” Iași, Romania
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METABOLIC PROFILING OF HALOPERIDOL: INSIGHTS INTO POTENTIAL TOXICOLOGICAL EFFECTS ON BRAIN MICROVASCULAR ENDOTHELIAL CELLS
SURACHAI NGAMRATANAPAIBOON 1*, PRACHA YAMBANGYANG 2, PHICHANAN DUCHDA 3,4, JENYUK LOHWACHARIN 3,4, WATCHARAPORN DEVAKUL NA AYUTTHAYA 1
1Division of Pharmacology, Department of Basic Medical Sciences, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand
2Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Salaya, Nakhon Pathom, 73170, Thailand
3Department of Environmental Engineering, Faculty of Engineering, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand
4Professor Aroon Sorathesn Center of Excellence in Environmental Engineering, Department of Environmental Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand -
ANALYSIS OF MAGNETIC RESONANCE PROBE-BASED OXALIPLATIN-RESVERATROL DRUG RELEASE-CONTROLLED NANOPARTICLE THERAPY FOR COLORECTAL CANCER
XIAOWANG BI, QI ZHANG, ZHE QI, LITAO SONG *
Department of Radiology, Zibo Central Hospital, Zibo, 255000, Shandong, China.
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DOSAGE OF STREPTOZOTOCIN FOR INDUCING MODELS OF DIABETES MELLITUS IN OBESITY RATS WITH ENDOTHELIAL DYSFUNCTION
ANDREEA CLIM 1#, MINELA AIDA MARANDUCĂ 1,2#, ALIN CONSTANTIN PINZARIU 1, IONUT FLAVIU FAUR 3,4, BOGDAN HUZUM 5, MONICA HĂNCIANU 6*, ANDREI SZILAGYI 7, BOGDAN IONEL TAMBA 7, DRAGOMIR NICOLAE ȘERBAN 1, IONELA LĂCRĂMIOARA ȘERBAN 1
1Department of Morpho-Functional Sciences II, Discipline of Physiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iași, Romania
2Internal Medicine Clinic, “St. Spiridon” County Clinical Emergency Hospital, 700115 Iași, Romania
3IInd Surgery Clinic, Timișoara Emergency County Hospital, 300723 Timișoara, Romania
4Xth Department of General Surgery, “Victor Babes” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
5Department of Orthopaedic and Traumatology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115, Iași, Romania
6”Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, 16 Universitatii Street, 700115, Iasi, Romania
7Advanced Research and Development Centre in Experimental Medicine (CEMEX), Grigore T. Popa University of Medicine and Pharmacy, 700115 Iași, Romania -
MEDICATION-RELATED BURDEN AMONG IRAQI HEMODIALYSIS PATIENTS
SHAYMAA A. HUSEIN 1*, DHEYAA J. KADHIM 2
1Renal Transplant Centre, Baghdad Medical City, Baghdad, Iraq.
2Clinical Pharmacy Department, College of Pharmacy, University of Baghdad, Iraq. -
A DOUBLE PERSPECTIVE ON BOTULINUM TOXIN IN ROMANIA USED FOR AESTHETIC CLINICAL APPLICATIONS
ANDREI MARIN 1,5#, LAVINIA-ALICE BĂLĂCEANU 2,5#, SILVIU-ADRIAN MARINESCU 3,5*, GEORGE-TRAIAN-ALEXANDRU BURCEA-DRAGOMIROIU 4,5, MARIA-ALEXANDRA DÎDĂ 1,6, ALEXANDRA MIRICĂ 5,7, CARMEN GIUGLEA 1,5
1Plastic Surgery Department, “Sf. Ioan” Hospital, 042122, Bucharest, Romania
2Internal Medicine Department, “Sf. Ioan” Hospital, 042122, Bucharest, Romania
3Plastic Surgery Department, “Bagdasar Arseni” Hospital, 041915, Bucharest, Romania
4Drug Control Department, Faculty of Pharmacy, 031215, Bucharest, Romania
5“Carol Davila” University of Medicine and Pharmacy, 020021, Bucharest, Romania
6Plastic Surgery Department, “Carol Davila” Military Emergency University Hospital, 010825, Bucharest, Romania
7“Grigore Alexandrescu” Emergency Clinic Hospital for Children, 011743, Bucharest, Romania -
PREVALENCE AND SATISFACTION LEVELS OF COMPLEMENTARY ALTERNATIVE MEDICINE USE FOR THE HEADACHES – A CROSSSECTIONAL STUDY
WAJID SYED 1*, MOHAMMED M ALBALAWI 2 , OSAMA A SAMARKANDI 3 , SHOGAIR MSHAL ALMUTAIRI 2 , ABDULLAH M. ALOBAID 4 , MAHMOOD BASIL A. AL-RAWI 5 , SANA SAMREEN 6 , AYESHA IQBAL 7,8
1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
2Prince Sultan College for Emergency Medical Services, King Saud University, Riyadh, Saudi Arabia
3Basic Sciences Department, Prince Sultan College for Emergency Medical Services, King Saud University, Riyadh, Saudi Arabia
4Department of Accident and Trauma, Prince Sultan bin Abdulaziz College for Emergency Medical Services, King Saud
University, Riyadh 11451, Saudi Arabia
5Department of optometry, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
6Aurobindo College of Pharmacy, Warangal, Telangana, India
7Division of Pharmacy Practice and Policy, School of Pharmacy, University of Nottingham, United Kingdom
8Office of Lifelong Learning and the Physician Learning Program, Faculty of Medicine and Dentistry, University of Alberta,
AB T6G1C9 Edmonton, Canada