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ANALYSIS OF MAGNETIC RESONANCE PROBE-BASED OXALIPLATIN-RESVERATROL DRUG RELEASE-CONTROLLED NANOPARTICLE THERAPY FOR COLORECTAL CANCER

XIAOWANG BI, QI ZHANG, ZHE QI, LITAO SONG *

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The aim of this research was to investigate the effects of nanoparticles (NPs) of oxaliplatin (OXE) and resveratrol (Res) on colorectal cancer (CRC) therapy. Carboxymethylchitosan (CMCS)-OXE, CMCS-Res and CO-CMCS NPs were prepared using OXE and Res with CMCS as drug carrier. The efficacy of OXE alone and combined with Res in arresting CRC cell growth was evaluated. Toxicity was also tested on cells and in a mouse model. The nanoparticles were spherical and stable with sizes around 161 - 188 nm and negative charges. Combined treatment with OXE and Res affected tumour proteins and inhibited tumour growth without causing abnormalities in mice or changes in liver and kidney function. The nanoparticles also reduced certain proteins in tumour tissue and reduced the proportion of myeloid-derived suppressor cells, which showed potential in the treatment of CRC.