Farmacia Journal 2/2022
Volume 70 | Number 2 | Year 2022
Download this issue’s covers, and announcements.
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DIETARY AND PHARMACO-THERAPY IN SKIN DISEASES
IRINA MIHAELA MATRAN 1, ROXANA MARIA MARTIN-HADMAȘ 2*, CRISTINA NICULAȘ 3, DANIELA LUCIA MUNTEAN 4, MONICA TARCEA 2
1Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș,
Romania
2 Department of Community Nutrition and Food Hygiene, Faculty of Medicine, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania
3 Richter Pharmacy no 7, Cluj-Napoca, Romania
4 Department of Analytical Chemistry and Drug Analysis, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania -
LATE-ONSET EPILEPSY IN THE ELDERLY: DIFFICULTIES OF DIAGNOSIS AND PERSONALIZED PHARMACOLOGICAL MANAGEMENT, WITH PARTICULARITIES TO COVID-19 PANDEMIC – SYSTEMATIC REVIEW OF LITERATURE
AURELIAN ANGHELESCU 1,2#, GELU ONOSE 1,2#, VLAD CIOBANU 3, RUXANDRA
MIHALACHE 2,4*, AURA SPANU 1,2, CRISTINA POPESCU 1,2, MIHAELA OPREA 1,2, CARMEN FLORENTINA FIRAN 2,5, ALEXANDRU CAPISIZU 2,61Neurorehabilitation Department, Teaching Emergency Hospital “Bagdasar-Arseni”, Bucharest, Romania
2 “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3 Computer Science Department, Polytechnic University of Bucharest, Bucharest, Romania
4 Geriatrics Department, “Sf. Luca” Hospital, Bucharest, Romania 5Ilfov County Emergency Clinical Hospital, Bucharest, Romania
6 Psychiatric Hospital “Dr. C. Gorgos” Bucharest, Romania -
BOTULINUM TOXIN, TREATMENT OPTION FOR NEUROGENIC DETRUSOR OVERACTIVITY
CRISTIAN PERSU 1, DAVID MANUEL CASTRO-DIAZ 2, VIOREL JINGA 1, NARCIS CHIRCA 1*,
IRINA CIOFU 11“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 University Hospital of the Canary Islands, Santa Cruz de Tenerife, Spain -
DEVELOPMENT AND CHARACTERIZATION OF LORATADINE LIPOSOMAL GEL USING QbD APPROACH
IOANA TOMA 1, LUCIA RUXANDRA TEFAS 1*, CĂTĂLINA BOGDAN 2, IOAN TOMUȚĂ 1
1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy
“Iuliu Hațieganu”, 41 Victor Babeș Street, 400012, Cluj-Napoca, Romania
2 Department of Dermopharmacy and Cosmetics, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Hațieganu”, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania -
PHENOLICS CONTENT, ANTIOXIDANT POTENTIAL, α-GLUCOSIDASE AND α-AMYLASE INHIBITORY ACTIVITIES OF FOUR FOLIAR EXTRACTS FROM PINUS SPECIES
ELI AMANDA DELGADO-ALVARADO, NORMA ALMARAZ-ABARCA *, YOLANDA
HERRERA-ARRIETA, RENE TORRES-RICARIO, LAURA SILVIA GONZÁLEZ-VALDEZ, JOSÉ ANTONIO ÁVILA-REYES, NÉSTOR NARANJO-JIMÉNEZThe current study focused on determining the contents of total phenolics (TP), flavonoids (FC), condensed tannins (CT), the flavonoid profiles, antioxidant potentials and α-glucosidase and α-amylase inhibitory capacities of the foliar extracts of Pinus engelmannii Carr., Pinus arizonica Engelm., Pinus durangensis Martínez and Pinus cembroides Zucc. Specific variations were found in TP, FC, CT, antioxidant potentials and α-glucosidase and α-amylase inhibitory activities. Pinus durangensis highlighted for its high level of FC (3.70 mg/g dry extract), high DPPH● scavenging activity, high ABTS●+ reducing potential, as well as its high inhibitory activity of α-glucosidase and α-amylase, whereas Pinus engelmannii for its high values of TP (340.15 mg/g dry extract) and CT (72.49 mg/g dry extract). Particularly, Pinus durangensis could support the development of hypoglycaemic treatments. The flavonoid profiles obtained by HPLC were species-specific, thus may be used for the development of chemical fingerprinting and quality control tools for the botanical authenticity of the bioactive extracts of these species of Pinus.
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DENATONIUM BENZOATE ATTENUATES INFLAMMATION AND PAIN AND DECREASES PGE2 LEVELS IN RATS
VESELA YULIEVA KOKOVA 1, MILENA NENKOVA DRAGANOVA-FILIPOVA 2,3, PLAMEN
IVANOV ZAGORCHEV 3,4, LYUDMIL PEYCHEV PEYCHEV 1, ELISAVETA GEORGIEVA APOSTOLOVA 1*1Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, 15A Vassil Aprilov Boulevard, 4002 Plovdiv, Bulgaria
2 Department of Medical Biology, Medical Faculty, Medical University-Plovdiv, 15A Vassil Aprilov Boulevard, 4002 Plovdiv, Bulgaria
3 Research Institute at Medical University-Plovdiv, 15A Vassil Aprilov Boulevard, 4002 Plovdiv, Bulgaria
4 Department of Medical Physics and Biophysics, Faculty of Pharmacy, Medical University-Plovdiv, 15A Vassil Aprilov Boulevard, 4002 Plovdiv, Bulgaria -
A QSAR STUDY ON THIOUREA DERIVATIVES – NEW APPROACHES IN DRUG DEVELOPMENT
ROXANA ROMAN 1, LUCIA PINTILIE 2*, DIANA NUȚĂ 1, CARMEN LIMBAN 1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6
Traian Vuia Street, 020956 Bucharest, Romania
2 National Institute of Chemical-Pharmaceutical Research & Development, 112 Vitan Avenue, 031299 Bucharest, Romania -
PHYTOCHEMICAL COMPOSITION AND IN VITRO BIOLOGICAL PROPERTIES OF SEVERAL RUDBECKIA HIRTA AND TAGETES ERECTA FLOWER EXTRACTS
ANA FLAVIA BURLEC 1#, ANDREIA CORCIOVA 1#, ANA-MARIA VLASE 2, LAURIAN VLASE 2,
CORNELIA MIRCEA 1*, CRISTINA TUCHILUȘ 3, CRISTINA FURNICA 3, FAWZIA SHA’AT 4, SILVIA ROBU 5, OANA CIOANCA 1, MONICA HANCIANU 11Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115, Iași, Romania 2Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca,
Romania 3Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115, Iași, Romania 4National Institute of Chemical Pharmaceutical R&D (INCDCF), 112 Vitan Road, 031299, Bucharest, Romania 5Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 800010 Galați, Romania -
PHYTOCHEMICAL SCREENING AND BIOLOGICAL ACTIVITY OF ETHANOLIC EXTRACT OF ROSA X DAMASCENA MILL. CULTIVATED IN THE WESTERN REGION OF ROMANIA
DIANA IOANA GAVRA 1, ELEONORA MARIAN 2, ANNAMÁRIA PALLAG 2, LAURA
GRAȚIELA VICAȘ 2*, ROXANA LIANA LUCACIU 3, OTILIA MICLE 2, CORINA IONESCU 3,
ILDIKO BACSKAY 4, ADRIANA CORINA HANGAN 5, BOGDAN SEVASTRE 6, EMÖKE PÁLL 6, ANA-MARIA VLASE 7, LAURIAN VLASE 8, TÜNDE JURCA 21Doctoral School of Biomedical Science, University of Oradea, 1 University Street, 410087, Oradea, Romania
2 Faculty of Medicine and Pharmacy, University of Oradea, 10 Piața 1 Decembrie Street, 410073, Oradea, Romania
3 Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
4 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 98 Nagyerdei körút Street, 4032, Debrecen, Hungary
5 Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
6 Paraclinic/Clinic Department, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 3-5 Mănăștur Road, 400372, Cluj-Napoca, Romania 7Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
8 Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu Hațieganu” University of
Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania -
CYTOTOXIC EVALUATION OF ORIGINAL PYRAZOLO[3,4d]THIAZOLES AND PYRAZOLO[3,4-c]PYRAZOLES
NICU-COSMIN OSTACHE 1,2, ARNAUD PARIS 1, MARIE-AUDE HIEBEL 1, ADRIANA- LUMINIȚA FÎNARU 2, RICHARD DANIELLOU 1, FRANCK SUZENET 1, GÉRALD
GUILLAUMET 1*1Institut de Chimie Organique et Analytique (ICOA), Université d’Orleans UMR CNRS 7311, BP 6759, 45067 Orléans
Cedex 2, France
2 Center of Applied Chemistry and Process Engineering (CAIP), University Vasile Alecsandri of Bacău, 157 Calea Mărăşeşti Street, Bacău, 600115, Romania -
CLASS II PHOSPHATIDYLINOSITOL 3-KINASE 2ß IS A NOVEL TARGET FOR THE POTENTIAL DEVELOPMENT OF ANTIVIRAL DRUGS AGAINST THE HEPATITIS B VIRUS
DAVID PATRICHE, MIRELA POPESCU, COSTIN-IOAN POPESCU *, NORICA NICHITA
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POLYPHENOLIC PROFILE AND ANTI-INFLAMMATORY, ANALGESIC AND ANTIOXIDANT EFFECTS OF ETHANOLIC AND HYDRO-ETHANOLIC EXTRACTS OF HEINSIA CRINITA AFZ.G. TAYLOR AND TETRACERA ALNIFOLIA WILLD
LUCE SARRAH BOUMBA 1, ANAMARIA CRISTINA 2*, FREDY GELASE NSONDE NTANDOU 3, ILIOARA ONIGA 4, DANIELA BENEDEC 4, ANA-MARIA VLASE 5, OLIVIU VOSTINARU 2, ANGE ANTOINE ABENA 6, CRISTINA MOGOSAN 2
1Laboratory of Chemistry of Organic Biomolecules and Pharmacodynamics, Department of Pharmacopoeia and Traditional
Medicine, National Institute for Research in Health Sciences (IRSSA), Cité Scientifique, Brazzaville, Congo
2 Department of Pharmacology, Physiology and Physiopathology, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
3 Animal Physiology and Physiopathology Laboratory, Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, BP 69, Congo
4 Department of Pharmacognosy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
5 Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
6 Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, B.P. 69, Congo -
REDUCED BONE MINERAL DENSITY IN YOUNG, NON-CIRRHOTIC PATIENTS WITH CHRONIC VIRAL HEPATITIS
GEORGEANA ȚUCULEANU 1#, ECATERINA CONSTANȚA BARBU 1,2*, MIHAI LAZĂR 1,2#, CRISTINA EMILIA CHIȚU-TIȘU 1,2, CRISTINA MIHAELA OLARIU 1,2, MIHAI BOJINCĂ 1,3, CĂTĂLIN TILIȘCAN 1,2, ȘTEFAN SORIN ARAMĂ 1,2, VICTORIA ARAMĂ 1,2#, DANIELA ADRIANA ION 1,2
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 “Prof. Dr. Matei Balș” National Institute for Infectious Diseases, Bucharest, Romania 3“Dr. I. Cantacuzino” Clinical Hospital, Bucharest, Romania -
LC–ESI-MS/MS-BASED PHYTOCHEMICAL PROFILE, ANTIOXIDANT AND ENZYME INHIBITION ACTIVITIES OF EXTRACTS FROM COUSINIA AINTABESIS BOISS. & HAUSSKN
FATIMA KÜBRA YILMAZ 1, LEYLA PAŞAYEVA 1*, OSMAN TUGAY 2
1Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
2 Department of Pharmaceutical Botany, Faculty of Pharmacy, Selçuk University, Konya 42250, Turkey -
DETECTION OF ESCHERICHIA COLI FROM NON-STERILE HERBAL PHARMACEUTICAL PRODUCTS FROM THE ROMANIAN MARKET
MANUELA-CLAUDIA CURTICĂPEAN *
“George Emil Palade” University of Medicine, Pharmacy, Sciences, and Technology of Târgu Mureș, Faculty of Pharmacy,
Cell Biology and Microbiology Department, 38 Gh. Marinescu Street, 540139, Târgu Mureș, Romania -
CYTOMEGALOVIRUS INFECTION AND CARDIOVASCULAR RISK IN A MONOCENTRIC ROMANIAN ADULT PATIENT GROUP
CARMEN VALENTINA CRISTESCU 1, MANUELA GHICA 2*, DENISA IOANA UDEANU 2, ANCA IOANA AMZĂR 2, CLAUDIA DIȚĂ 3, CAMELIA GRANCEA 3, ROXANA SILIȘTE 4, ANA-MARIA VINTILĂ 4, CORINA SIMONA HOMENTCOVSCHI 4, SOPHIE ALAIN 5, SIMONA RUȚĂ 1,3,6
1Romanian Academy, 125 Calea Victoriei, 010071, Bucharest, Romania
2 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest,
Romania
3 “Ștefan S. Nicolau” Institute of Virology, 285 Mihai Bravu Road, 030304, Bucharest, Romania
4 Colțea Clinical Hospital, 1 Ion C. Brătianu Boulevard, 030171, Bucharest, Romania
5 National Reference Centre for Herpesviruses, University of Limoges, INSERM Laboratory, UMR 1092, 2 Rue du Pr Descottes, 87000 Limoges, France
6 “Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, 8 Eroii Sanitari Street, 050474, Bucharest, Romania -
IMPROVING STRUCTURE BASED MODELS FOR PREDICTING CHEMICAL FUNCTIONS AND WEIGHT FRACTIONS IN COSMETIC PRODUCTS USING ENSEMBLE SUPPORT VECTOR MACHINE
TANJA VOJINOVIC 1*, LJILJANA KASCELAN 2, ZORICA POTPARA 1, NATASA RADONJIC 1, ZORKA KASCELAN 1
1University of Montenegro, Faculty of Medicine, Pharmacy study program, Krusevac bb, 81 000 Podgorica, Montenegro 2University of Montenegro, Faculty of Economics, 37 Bulevar Jovana Tomasevica, 81000 Podgorica, Montenegro
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5-HYDROXITRYPTOPHAN DIETARY SUPPLEMENTATION IN POST-TRAUMATIC STRESS SYNDROME
RADU CIPRIAN ŢINCU 1,2, ADRIAN SILUAN IVAN 1, CRISTIAN COBILINSCHI 1,2, IULIA FLORENTINA ŢINCU 1,3*, RADU ALEXANDRU MACOVEI 1,2
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 2Clinical Emergency Hospital, Bucharest, Romania
3 “Dr. Victor Gomoiu” Clinical Children Hospital, Bucharest, Romania -
THE EFFECT OF PROPOFOL ON THE PROLIFERATION OF NEPHROBLASTOMA CELLS AND THE UNDERLYING MECHANISM
JUNJIANG LIU 1#, HONGMEI WANG 1#, XIN ZHAO 1, LIN LI 2, HONGLIAN XIA 2, YAN LIU 2,3*
1First Clinical Medical College, Mudanjiang Medical University, Mudanjiang, 157011, China
2 Department of Anesthesiology, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011, China
3 Department of Anesthesiology, Hengqin Branch of Zhuhai People's Hospital, Zhuhai, 519000, China -
INFLUENCE OF DISSOLUTION CONDITIONS ON THE DISSOLUTION RATE AND RELEASE MECHANISM OF KETOPROFEN FROM EXTENDED RELEASE HYDROPHILIC MATRIX SYSTEMS
TIBOR CASIAN 1, ANDRA CASIAN 1, ALEXANDRU GAVAN 2*, IOAN TOMUȚĂ 1
1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012, Cluj-Napoca, Romania
2 Department of Medical Devices, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349, Cluj-Napoca, Romania -
DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF PYRROLE-BASED COMPOUNDS AS ANTIOXIDANT AND MAO-B INHIBITORY AGENTS
EMILIO MATEEV 1*, BORISLAV ANGELOV 2, MAGDALENA KONDEVA-BURDINA 2, IVA VALKOVA 3, MAYA GEORGIEVA 1, ALEXANDER ZLATKOV 1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University – Sofia, Bulgaria
2 Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University – Sofia, Bulgaria 3Department of Chemistry, Faculty of Pharmacy, Medical University – Sofia, Bulgaria -
THERAPIES AND BONE IMPAIRMENT IN INFLAMMATORY BOWEL DISEASE YOUNG ADULTS
IULIA SOARE 1, ANCA SIRBU 1,2*, MIRCEA DICULESCU 1,3, BOGDAN MATEESCU 1,4, CRISTIAN TIERANU 1,5, SORIN IOACARA 1,2, MIRELA IONESCU 1,5, SIMONA FICA 1,2
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2 Department of Endocrinology, Diabetes and Metabolic Diseases, Elias University and Emergency Hospital, Bucharest, Romania
3 Department of Gastroenterology, Fundeni Clinical Institute, Bucharest, Romania
4 Department of Gastroenterology, Colentina Hospital, Bucharest, Romania
5 Department of Gastroenterology, Elias University and Emergency Hospital, Bucharest, Romania -
ANTINOCICEPTIVE EFFECT OF 4-ALLYL-2-METHOXYPHENOL AND DICLOFENAC CO-ADMINISTRATION IN THE FORMALIN TEST IN RATS
OLGA EDITH GONZÁLEZ-LUGO 1, JUAN RAMÓN ZAPATA-MORALES 2, AMAURY DE JESÚS POZOS GUILLÉN 3, ABELARDO CAMACHO LUIS 4, PATRICIA PONCE PEÑA 5, AZAHEL DE JESÚS RANGEL LÓPEZ 1, ANGEL ANTONIO VÉRTIZ HERNÁNDEZ 1*
1Region Altiplano Academic Coordination, Autonomous University of San Luis Potosí. San Luis Potosí, México
2 Pharmacy Department, Division of Natural and Exact Sciences, University of Guanajuato, México
3 Faculty of Dentistry Autonomous University of San Luis Potosí. San Luis Potosí, México
4 Food and Nutrition Center, Faculty of Medicine and Nutrition, Juarez University of the State of Durango, México
5 Faculty of Chemical Sciences, Juarez University of the State of Durango, México -
ROLE OF THE PHARMACIST IN IMPROVING INHALER TECHNIQUE IN PATIENTS’ OPINION IN POZNAN (POLAND)
BEATA PLEWKA 1*, MAGDALENA WASZYK-NOWACZYK 1, PATRYCJA TARGOSZ 2, WERONIKA GUZENDA 1, MICHAŁ BYLINIAK 3, PIOTR DĄBROWIECKI 4, MICHAŁ
MICHALAK 5, KAROLINA KAMASA 2, MAGDALENA PRZYBYLSKA 2, JERZY ŻABIŃSKI 61Pharmacy Practice Division, Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland
2 Student’s Pharmaceutical Care Group, Department of Pharmaceutical Technology, Pharmacy Practice Division, Poznan
University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland
3 Polish Pharmaceutical Chamber, 77 lok. 6 Żeromskiego Street, 01-882 Warsaw, Poland
4 Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów Street 128, 04-141 Warsaw, Poland 5Chair and Department of Computer Science and Statistics, Poznan University of Medical Sciences, 7 Rokietnicka Street, 60806 Poznan, Poland
6 Department of Organic Chemistry, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland -
KNOWLEDGE AND ATTITUDE OF PHARMACY STUDENTS TOWARDS COVID-19 PANDEMIC AND ITS IMPACT ON THEIR EDUCATION AND LEARNING
BASIT L. JAN 1, BASIL ALBADRNI 2, WAJID SYED 1, AJAZ AHMAD 1, KHALID M. ALKHARFY 1*
1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
2 College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia