Romanian Society of Pharmaceutical Sciences
 

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PHYTOCHEMICAL SCREENING AND BIOLOGICAL ACTIVITY OF ETHANOLIC EXTRACT OF ROSA X DAMASCENA MILL. CULTIVATED IN THE WESTERN REGION OF ROMANIA

DIANA IOANA GAVRA 1, ELEONORA MARIAN 2, ANNAMÁRIA PALLAG 2, LAURA
GRAȚIELA VICAȘ 2*, ROXANA LIANA LUCACIU 3, OTILIA MICLE 2, CORINA IONESCU 3,
ILDIKO BACSKAY 4, ADRIANA CORINA HANGAN 5, BOGDAN SEVASTRE 6, EMÖKE PÁLL 6, ANA-MARIA VLASE 7, LAURIAN VLASE 8, TÜNDE JURCA 2

1Doctoral School of Biomedical Science, University of Oradea, 1 University Street, 410087, Oradea, Romania
2Faculty of Medicine and Pharmacy, University of Oradea, 10 Piața 1 Decembrie Street, 410073, Oradea, Romania
3Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
4Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 98 Nagyerdei körút Street, 4032, Debrecen, Hungary
5Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
6Paraclinic/Clinic Department, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 3-5 Mănăștur Road, 400372, Cluj-Napoca, Romania 7Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
8Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu Hațieganu” University of
Medicine and Pharmacy, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania

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Rosa x damascena Mill. has pharmacological properties that are partially attributed to their abundance in phenolic compounds. We investigated the alcoholic extract from the plants petals. Microscopic examination of Rosa x damascena Mill. petals showed that both of the adaxial and abaxial epidermal cells contained pigments. The antimicrobial activity of the extract was determined by the disc diffusion method. The most sensitive antimicrobial effect was on the strain Pseudomonas aeruginosa. The SOD-like activity of Rosa damascena alcoholic extract has been tested both in vitro and in vivo. Three cell lines were used for determining the cytotoxicity of Rosa damascena alcoholic extract, a human cervical carcinoma line (HeLa), a human radical growth phase melanoma cell line (WM35) and a normal fibroblastic epithelial cell line (HFL1) by MTT method. The Rosa damascena extract presents SOD-like activity and is cytotoxic on HeLa and WM35 cell lines. Due to these results, Rosa x damascena extracts can be used for their bioactive potential.