Romanian Society of Pharmaceutical Sciences
 

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CYTOMEGALOVIRUS INFECTION AND CARDIOVASCULAR RISK IN A MONOCENTRIC ROMANIAN ADULT PATIENT GROUP

CARMEN VALENTINA CRISTESCU 1, MANUELA GHICA 2*, DENISA IOANA UDEANU 2, ANCA IOANA AMZĂR 2, CLAUDIA DIȚĂ 3, CAMELIA GRANCEA 3, ROXANA SILIȘTE 4, ANA-MARIA VINTILĂ 4, CORINA SIMONA HOMENTCOVSCHI 4, SOPHIE ALAIN 5, SIMONA RUȚĂ 1,3,6

1Romanian Academy, 125 Calea Victoriei, 010071, Bucharest, Romania
2 “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6 Traian Vuia Street, 020956, Bucharest,
Romania
3 “Ștefan S. Nicolau” Institute of Virology, 285 Mihai Bravu Road, 030304, Bucharest, Romania
4 Colțea Clinical Hospital, 1 Ion C. Brătianu Boulevard, 030171, Bucharest, Romania
5 National Reference Centre for Herpesviruses, University of Limoges, INSERM Laboratory, UMR 1092, 2 Rue du Pr Descottes, 87000 Limoges, France
6 “Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, 8 Eroii Sanitari Street, 050474, Bucharest, Romania

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Cytomegalovirus (CMV) is a widely distributed herpes virus in human populations that rarely causes any symptoms to healthy individuals. The infection can lead to serious health complications and even death for immature and immunocompromised people. Multiple studies have suggested that CMV could be a risk factor for developing cardiovascular diseases even in healthy carriers. Atherosclerosis is the root cause of many diseases like stroke or cardiovascular-related pathologies like angina, ischemic heart disease, acute myocardial infarction and cardiovascular death. In this study, we aimed to demonstrate the link between CMV serostatus and cardiovascular parameters like left ventricle mass and cholesterol level in a cohort of 145 volunteers. Also, we researched the benefits of cholesterol-lowering drugs in the prevention of CMV induced atherogenesis. The study revealed that the severity of cardiovascular disease is associated with an increased CMV IgG titter.