Farmacia Journal 5/2016

Volume 64 | Number 5 | Year 2016

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PHARMACOLOGICAL TREATMENT OF RELAPSING REMITTING MULTIPLE SCLEROSIS-WHERE ARE WE?

CARMEN ADELLA SIRBU ^1#, EMILIA FURDU-LUNGUT ^1#, CRISTINA FLORENTINA PLESA ^1#, ALINA CRENGUȚA NICOLAE ^2#*, CRISTINA MANUELA DRAGOI ^2#

1.Central University Emergency Military Hospital “Carol Davila”, Department of Neurology, 134, Calea Plevnei Str., Bucharest, Romania
2.University of Medicine and Pharmacy ”Carol Davila”, Faculty of Pharmacy, Department of Biochemistry, 6, Traian Vuia Str., Bucharest, Romania

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A REVIEW ON THE PHYSIOLOGICAL AND PHARMACOLOGICAL INFLUENCE OF VASCULAR TONE IN CHOROIDAL AND CONJUNCTIVAL EYE TERRITORIES

AURELIAN ZUGRAVU ^1#, ISABEL CRISTINA VIORICA GHIȚĂ ^1#*, HORIA PĂUNESCU ^1#, LAURENȚIU COMAN ^2#, OANA ANDREIA COMAN ^1#, ION FULGA ^1#

1.Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy
2.Department of Physiology, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy

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PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF HYPERICUM HUMIFUSUM L. (HYPERICACEAE)

ANCA TOIU¹, LAURIAN VLASE², CRISTINA MANUELA DRĂGOI^3*, DAN VODNAR⁴, ILIOARA ONIGA¹

1.Department of Pharmacognosy, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca, Romania
2.Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca, Romania
3.Department of Biochemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6, Traian Vuia Street, sector 2, Bucharest, Romania
4.Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 3-5, Manăştur Street, Cluj-Napoca, Romania

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INHIBITION OF NF–KB AND STAT3 BY QUERCETIN WITH SUPPRESSION OF ADHESION MOLECULE EXPRESSION IN VASCULAR ENDOTHELIAL CELLS

YOUNG-SUK CHO ^1#, CHAN HYUNG KIM ^1#, TAE–SUN HA ², HEE YUL AHN ^1*

1.Department of Pharmacology, College of Medicine, Chungbuk University, Cheongju, 362-763 Republic of Korea
2.Department of Pediatrics, College of Medicine, Chungbuk University, Cheongju, 362-763 Republic of Korea

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SIDE EFFECTS INDUCED BY HYPOGLYCAEMIC SULFONYLUREAS TO DIABETIC PATIENTS – A RETROSPECTIVE STUDY

LUMINIȚA CONFEDERAT¹, ROXANA ȘTEFAN², FLORENTINA LUPAŞCU¹, SANDRA CONSTANTIN¹, IUSTINA AVRAM¹, ADRIAN DOLOCA³, LENUȚA PROFIRE^1*

1.Department of Pharmaceutical Sciences I, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iaşi, România
2.”Providența” Medical Centre – Iași, 10 Ștefan cel Mare Avenue, Iași, România
3.Department of Preventive Medicine and Interdisciplinarity, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iaşi, România

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PRELIMINARY RESEARCH CONCERNING THE OBTAINING OF HERBAL EXTRACTS WITH POTENTIAL NEUROPROTECTIVE ACTIVITY NOTE I. OBTAINING AND CHARACTERIZATION OF A SELECTIVE ORIGANUM VULGARE L. DRY EXTRACT

CERASELA ELENA GÎRD¹, LIGIA ELENA DUŢU¹, TEODORA COSTEA^1*, IOANA NENCU¹, MARIA LIDIA POPESCU¹, OLARU OCTAVIAN TUDOREL²

1."Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacognosy, Phytochemistry and Phytotherapy Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
2."Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Botany and Cellular Biology Department, 6 Traian Vuia Street, 020956, Bucharest, Romania

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GOLD NANOPARTICLES CONJUGATED WITH RITUXIMAB FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKAEMIA

SANDA BOCA ^1,2#, CIPRIAN LUCAN ^3#, IOANA FRINC ^4#, BOBE PETRUSHEV⁵, TIMEA SIMON^1,2, CRISTIAN BERCE⁶, GRIGORE-ARISTIDE GAFENCU⁷, DELIA DIMA⁴, ALINA TANASE⁸, SONIA SELICEAN⁷, VALENTINA PILECZKI^7,9, LAURA POP⁷, VLAD MOISOIU⁷, ANCA BUZOIANU¹⁰, ADRIAN FLOREA¹¹, ALEXANDRU IRIMIE^12,13, SIMION ASTILEAN^1,2, ANCA BOJAN^4,14, IOANA BERINDAN-NEAGOE^7,10, CIPRIAN TOMULEASA^4,7*

1.Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute in Bio-Nano-Sciences, “Babes-Bolyai” University Cluj-Napoca, Romania
2.Faculty of Physics, “Babes-Bolyai” University, Cluj-Napoca, Romania
3.Department of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
4.Department of Haematology, “Ion Chiricuta” Oncology Institute, Cluj-Napoca, Romania
5.Department of Pathology, Emergency County Hospital, Cluj-Napoca, Romania
6.Animal Facility, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
7.Research Center for Functional Genomics and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
8.Department of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, Romania
9.Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
10.Department of Pharmacology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
11.Department of Cell and Molecular Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
12.Department of Surgical and Gynaecological Oncology, “Ion Chiricuta” Oncology Institute, Cluj-Napoca, Romania
13.Department of Surgery, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
14.Department of Haematology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania

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COMPARATIVE ANALYSIS BY HPLC-UV AND CAPILLARY ELECTROPHORESIS OF DIETARY SUPPLEMENTS FOR WEIGHT LOSS

AMELIA TERO-VESCAN¹, CAMIL-EUGEN VARI^2*, SILVIA IMRE³, BIANCA-EUGENIA ŐSZ², CRISTINA FILIP¹, GABRIEL HANCU⁴

University of Medicine and Pharmacy, Faculty of Pharmacy, 38 Gheorghe Marinescu Street, Târgu Mureș, 540139, Romania
1.Biochemistry and Chemistry of Environmental Factors Department
2.Farmacology and Clinical Pharmacy Department
3.Organic Chemistry Department
4.Pharmaceutical Chemistry Department

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IN VITRO ANTIOXIDANT ACTIVITY OF EIGHT WILD EDIBLE PLANTS IN BURSA PROVINCE OF TURKEY

TURGUT TASKIN, LEYLA BITIS*

Department of Pharmacognosy, Faculty of Pharmacy, Marmara University, Turkey

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IN VITRO STUDIES REGARDING THE INTERACTIONS OF SOME NOVEL RUTHENIUM (III) COMPLEXES WITH DOUBLE STRANDED CALF THYMUS DEOXYRIBONUCLEIC ACID (DNA)

ANDREEA LETIŢIA ARSENE¹, VALENTINA UIVAROSI², NICULINA MITREA³, CRISTINA MANUELA DRĂGOI^3*, ALINA CRENGUŢA NICOLAE³

1.Department of Microbiology, Faculty of Pharmacy, University of Medicine and Pharmacy ”Carol Davila”, 6, Traian Vuia Str, sector 2, Bucharest, Romania
2.Department of General and Inorganic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy ”Carol Davila”, 6, Traian Vuia Str, sector 2, Bucharest, Romania
3.Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy ”Carol Davila”, 6, Traian Vuia Str, sector 2, Bucharest, Romania

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ASSESSMENT OF IN VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF NEW AZETIDIN-2-ONE DERIVATIVES OF FERULIC ACID

MARIA DRĂGAN¹, CĂTĂLINA DANIELA STAN^1*, ANDREEA IACOB², LENUŢA PROFIRE²

Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania
1.Department of Drug Industry and Pharmaceutical Biotechnology
2.Department of Pharmaceutical Chemistry

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RESEARCH CONCERNING METABOLIC AND ANTIOXIDANT EFFECTS OF THE ETHANOLIC EXTRACT FROM SYRINGAE VULGARIS FLOS F. ALBA IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

ANCA BERBECARU-IOVAN^1#, ANA MARINA ANDREI^2#, ALINA CRENGUȚA NICOLAE^5#, CAMELIA ELENA STĂNCIULESCU^2#, SORIN BERBECARU-IOVAN^3#*, GEORGE DAN MOGOŞANU^4#, CĂTĂLINA GABRIELA PISOSCHI^2#

1.Department of Pharmacology, Faculty of Pharmacy, University of Medicine and Pharmacy, 2 Petru Rareş, 200349, Craiova, Romania,
2.Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy, 2 Petru Rareş, 200349, Craiova, Romania,
3.Department of Medical Sciences, Faculty of Medicine, University of Medicine and Pharmacy, 2 Petru Rareş, 200349, Craiova, Romania,
4.Department of Pharmacognosy-Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy, 2 Petru Rareş, 200349, Craiova, Romania,
5.Department of Biochemistry, Faculty of Pharmacy, ”Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania.

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INFLUENCE OF FORMULATION VARIABLES ON KETOPROFEN DIFFUSION PROFILES FROM HYDROALCOHOLIC GELS

CORINA DALIA TODERESCU^1,2#, CRISTINA DINU-PÎRVU^1#, MIHAELA VIOLETA GHICA^1#, VALENTINA ANUȚA^1#*, DANIELA ELENA POPA^1#,LAVINIA VLAIA^3#, DUMITRU LUPULIASA^1#

1.Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956, Bucharest, Romania
2.Faculty of Pharmacy, Department of Pharmaceutical Sciences, ”Vasile Goldis” Western University of Arad, 86 L. Rebreanu Str., Arad, Romania
3.Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, Timisoara, Romania

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ANTIPSYCHOTIC TREATMENT EMERGENT ADVERSE EVENTS IN CORRELATION WITH THE PHARMACOGENETIC TESTING AND DRUG INTERACTIONS IN CHILDREN AND ADOLESCENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER

NICOLETA ANDREESCU ^1#, LAURA NUSSBAUM ^2#*, LAVINIA MARIA HOGEA^3#, RALUCA GRĂDINARU¹, CĂLIN MUNTEAN^4#, RADU ȘTEFĂNESCU⁵, MARIA PUIU¹

1.Genetics Discipline, Microscopic Morphology Department, University of Medicine and Pharmacy “Victor Babeș”, no. 2, E. Murgu Square Timișoara, Romania
2.Pedopsychiatry Discipline, Department of Neurosciences, University of Medicine and Pharmacy “Victor Babeș”, no. 2, E. Murgu Square, Timișoara, Romania
3.Psychology Discipline, Department of Neurosciences, University of Medicine and Pharmacy “Victor Babeș”, no. 14, T. Vladimirescu Street, Timișoara, Romania
4.Discipline of Informatics and Medical Biostatistics, Department of Functional Sciences, University of Medicine and Pharmacy “Victor Babeș”, no. 14, T. Vladimirescu Street, Timișoara, Romania
5.Titu Maiorescu University, School of Medicine, Bucharest, Romania

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EXPLORING THE STRUCTURAL INSIGHTS OF INDOLE-7-CARBOXAMIDES AS ANTI-HIV AGENTS

VEERASAMY RAVICHANDRAN^*, SIVADASAN SHALINI, KRISHNAMOORTHY VENKATESKUMAR, SOKKALINGAM ARUMUGAM DHANARAJ

Faculty of Pharmacy, AIMST University, Semeling – 08100, Kedah, Malaysia

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THE EFFICACY OF PIROXICAM/LIDOCAINE/CYCLOBENZAPRINE HYDROCHLORIDE TOPICAL GEL IN THE PAIN MANAGEMENT DURING EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY (ESWL)

CĂTĂLIN PRICOP^1,2, IRINA NEGRU^1,2, CĂTĂLIN CIUTĂ², VIOREL JINGA^3,4, ADRIANA ILIEȘIU^4*, IONEL ALEXANDRU CHECHERIȚĂ^3,5, LIVIU TODOSI^1,2, DANIEL RADAVOI^3,4, MARIANA JINGA⁵

1.Departament of Surgery – Urology, “Grigore T. Popa” University of Medicine and Pharmacy Iași, 16 Universitatii Street, 700115, Iași, Romania
2.Department of Urology, “Dr. C. I. Parhon” Clinical Hospital, 50 Carol I Bulevard, 700503, Iași, Romania
3.Clinical Department No. 3, “Carol Davila” University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu Street, 020022, Bucharest, Romania
4.Department of Urology 3, “Prof. Dr. Theodor Burghele” Urology Clinical Hospital, 20 Panduri Road, 050659, Bucharest, Romania
5.Department of Nephrology and Dialysis, “Sf. Ioan” Emergency Clinical Hospital, 13 Vitan-Bârzești Road, 042122, Bucharest, Romania
4.Department of Internal Medicine and Cardiology, “Prof. Dr. Theodor Burghele” Urology Clinical Hospital, 20 Panduri Road, 050659, Bucharest, Romania
5.Central University Emergency Military Hospital “Carol Davila”, 88 Calea Plevnei Str., 010825, Bucharest, Romania

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NON-CLINICAL TOXICITY AND PHYTOTOXICITY OF TWO HERBAL EXTRACTS

ROBERT ANCUCEANU¹, CRISTINA ELENA ZBÂRCEA^2*, MARIA COJOCARU-TOMA³, TATIANA CALALB³, ADRIANA IULIANA ANGHEL¹, SIMONA NEGREŞ², MIHAELA DINU¹, MARILENA VIORICA HOVANEŢ¹

1.University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical Botany and Cell Biology, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmacology, 6 Traian Vuia Street, 020956, Bucharest, Romania
3.State University of Medicine and Pharmacy “Nicolae Testemiţanu”, Faculty of Pharmacy, Department of Pharmacognosy and Pharmaceutical Botany, 165 Stefan cel Mare și Sfint Street, Chisinau, Republic of Moldova

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TRENDS IN ANTIMICROBIALS CONSUMPTION AND ANTIMICROBIAL RESISTANCE IN AN INFECTIOUS DISEASES HOSPITAL FROM THE SOUTH-EASTERN REGION OF ROMANIA

MIRUNA DRAGANESCU¹, ALINA VIORICA IANCU², DOREL FIRESCU¹, OLIMPIA DUMITRIU BUZIA³, CAMELIA DIACONU^3*, LAURA REBEGEA¹

1.Clinic Department, Faculty of Medicine, “Dunărea de Jos” University of Galați, Romania
2.Department of Morphological and Functional Sciences, Faculty of Medicine, “Dunărea de Jos” University of Galați, Romania
3.Department of Pharmaceutical Sciences, “Dunărea de Jos” University of Medicine and Pharmacy, Galați, Romania

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SYNTHESIS OF SOME NEW 2-((4-CHLOROPHENOXY)METHYL)-N-(ARYLCARBAMOTHIOYL) BENZAMIDES AS POTENTIAL ANTIFUNGAL AGENTS

CARMEN LIMBAN¹, ALEXANDRU VASILE MISSIR¹ DIANA CAMELIA NUŢĂ^1*, MIRON TEODOR CĂPROIU², MARIUS TOMA PAPACOCEA³, CORNEL CHIRIŢĂ¹

1.University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, Bucharest, Romania, 6 Traian Vuia St., Bucharest, 020956, Romania
2.“C. D. Neniţescu” Organic Chemistry Center of the Romanian Academy, Splaiul Independenţei 202B, Bucharest, Romania
3.University of Medicine and Pharmacy „Carol Davila” Bucharest, Clinical Emergency Hospital "Sf. Pantelimon", Șoseaua Pantelimon, 340-342, Bucharest, Romania

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CLINICAL EFFICACY OF MOMETASONE FUROATE INHALATION THERAPY IN ADULTS WITH POST-UPPER RESPIRATORY TRACT INFECTION COUGH

SHANSHAN FENG¹, GUOWEN ZHAN¹, XIAOYA JING¹, YANYAN CHEN², YOUXIONG YANG^1*, HONGLI WANG¹

1.Ningbo Yinzhou No. 2 Hospital, ENT Department, Ningbo, Zhejiang 315100, China
2.Ningbo Medical Treatment Center Lihuili Hospital Ningbo, Zhejiang 315100, China

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EFFECT OF PLATELETS ANTIAGGREGANT CLOPIDOGREL ON ERYTHROCYTES AGGREGATION AND SEDIMENTATION

STILIYANA BORISOVA¹, IULIAN SARBU¹, SIMONA NICOLETA SAVU^1,2, ERAND MATI^1*

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Doctoral School, Bucharest, Romania
2.Pharma Serv Int’l SRL, 52 Sabinelor Str., 5th District, 050853 Bucharest, Romania

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ANALYSIS OF PERFUMES WITH SYNTHETIC HUMAN PHEROMONES BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY

IOANA GAVRIȘ, EDE BODOKI^*, RADU OPREAN

Department of Analytical Chemistry, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 4, Louis Pasteur St., Cluj-Napoca, Romania

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LIPID DISORDERS IN KIDNEY TRANSPLANTATION: A PERSISTENT CONUNDRUM. IS THERE ANY CONNECTION WITH IMMUNOSUPPRESSIVE THERAPY?

IONUŢ-DORIN TARŢA¹, CARMEN DENISE CĂLDĂRARU^1*, MARIA TITICA DOGARU², EMILIAN CARAŞCA³, CRISTINA TARŢA⁴, MIHAI CIPRIAN STOICA¹, GRIGORE ALOIZIU DOGARU¹

University of Medicine and Pharmacy, Faculty of Pharmacy, 38 Gheorghe Marinescu Street, Târgu Mureș, 540139, Romania
1.Department of Nephrology,
2.Department of Pharmacology
3.IVth Internal Medicine Department
4.County Clinic Hospital Târgu-Mureş, Romania

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TOXICITY AND ANTI-INFLAMMATORY ACTIVITY OF ZIZIPHUS JUJUBA MILL. LEAVES

MARILENA-VIORICA HOVANEŢ¹, ROBERT VIOREL ANCUCEANU^1*, MIHAELA DINU¹, ELIZA OPREA², EMMA ADRIANA BUDURA³, SIMONA NEGREŞ⁴, BRUNO ŞTEFAN VELESCU⁴, LIGIA ELENA DUŢU⁵, IULIANA ADRIANA ANGHEL¹, IRINA ANCU⁶, ELENA MOROŞAN⁷, OANA CRISTINA ŞEREMET⁴

1.Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol Davila”, 6 Traian Vuia Street, Bucharest, Romania
2.Department of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, Faculty of Chemistry, 4-12 Regina Elisabeta Boulevard, Bucharest, Romania
3.Department of Pharmaceutical Technology Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol Davila”, 6 Traian Vuia Street, Bucharest, Romania
4.Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol Davila”, 6 Traian Vuia Street, Bucharest, Romania
5.Department of Pharmacognosy, Phytochemistry and Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol Davila”, 6 Traian Vuia Street, Bucharest, Romania
6.Research Institute for Fruit Growing, Rilomania, OP 1, CP 73, Argeș County, Romania
7.Department of Clinical Laboratory and Food Safety, Faculty of Pharmacy, University of Medicine and Pharmacy, “Carol Davila”, 6 Traian Vuia Street, Bucharest, Romania

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THE ANTIHYPERALGIC EFFECT OF MEMANTINE IN A RAT MODEL OF PACLITAXEL INDUCED NEUROPATHIC PAIN

IONUȚ COSMIN CIOTU¹, DUMITRU LUPULIASA², CORNEL CHIRIȚĂ¹, CRISTINA ELENA ZBÂRCEA^1*, SIMONA NEGREȘ¹

1.Pharmacology and Clinical Pharmacy Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, Traian Vuia no 6, Sect. 2, 020956, Bucharest, Romania
2.Pharmaceutical Technology and Biopharmacy Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, Traian Vuia no 6, Sect. 2, 020956, Bucharest, Romania

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