Romanian Society of Pharmaceutical Sciences
 

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TRENDS IN ANTIMICROBIALS CONSUMPTION AND ANTIMICROBIAL RESISTANCE IN AN INFECTIOUS DISEASES HOSPITAL FROM THE SOUTH-EASTERN REGION OF ROMANIA

MIRUNA DRAGANESCU1, ALINA VIORICA IANCU2, DOREL FIRESCU1, OLIMPIA DUMITRIU BUZIA3, CAMELIA DIACONU3*, LAURA REBEGEA1

1.Clinic Department, Faculty of Medicine, “Dunărea de Jos” University of Galați, Romania
2.Department of Morphological and Functional Sciences, Faculty of Medicine, “Dunărea de Jos” University of Galați, Romania
3.Department of Pharmaceutical Sciences, “Dunărea de Jos” University of Medicine and Pharmacy, Galați, Romania

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The aim of this study was to compare the antimicrobial preparations consumption with the resistance of the main bacterial species isolated in patients admitted to the Infectious Diseases Clinical Hospital “Sf. Cuv. Parascheva” of Galați. The bacterial strains have been identified in various pathological products (pharyngeal/nasal exudates, urine culture, coproculture, wound secretions, prosthetic devices/catheters, otic and conjunctival secretions, blood cultures, and puncture liquids) between 2013 and 2015 period. The antibiotics consumption in this hospital decreased for all antibiotics categories except for glycopeptides, whose usage doubled as a result of the increasing incidence of Clostridium difficile infections. The most often used class of antibiotics was that of penicillins, followed by cephalosporins and fluoroquinolones. The resistance of the isolated strains to antimicrobial agents increased, expressing resistance phenotypes of clinical and epidemiological significance, of which we can mention the increased incidence of the methicillin-resistant Staphylococcus aureus (MRSA) average 33.7%, and the production of extended-spectrum beta-lactamases (ESBL) in E. coli (12.7%) and in Klebsiella spp. (39.2%) in relation to the usage of cephalosporins of the third generation.