Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS OF SOME NEW 2-((4-CHLOROPHENOXY)METHYL)-N-(ARYLCARBAMOTHIOYL) BENZAMIDES AS POTENTIAL ANTIFUNGAL AGENTS

CARMEN LIMBAN1, ALEXANDRU VASILE MISSIR1 DIANA CAMELIA NUŢĂ1*, MIRON TEODOR CĂPROIU2, MARIUS TOMA PAPACOCEA3, CORNEL CHIRIŢĂ1

1.University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, Bucharest, Romania, 6 Traian Vuia St., Bucharest, 020956, Romania
2.“C. D. Neniţescu” Organic Chemistry Center of the Romanian Academy, Splaiul Independenţei 202B, Bucharest, Romania
3.University of Medicine and Pharmacy „Carol Davila” Bucharest, Clinical Emergency Hospital "Sf. Pantelimon", Șoseaua Pantelimon, 340-342, Bucharest, Romania

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As a continuation of our previous work on the synthesis of 2-((4-chlorophenoxy)methyl)-N-(arylcarbamothioyl) benzamides and in view of the antifungal activity characterization of these molecules, we report in this paper the obtaining of new molecules having this chemical structure. The new benzamides were synthesized by reacting 2-(4-chlorophenoxymethyl)benzoyl isothiocyanate with aromatic amines in dry acetone. All the chemical structures were evaluated and characterised by 1H-NMR, 13C-NMR, IR spectroscopy methods and by their physical properties (melting point, solubility).