Farmacia Journal 3/2020
Volume 68 | Number 3 | Year 2020
Download this issue’s covers and announcements.
-
DIABETES AND RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM: IMPLICATIONS FOR COVID-19 PATIENTS WITH DIABETES TREATMENT MANAGEMENT
DOINA CATRINOIU 1#, ANTONIO CERIELLO 2#, MANFREDI RIZZO 3,4, CRISTIAN SERAFINCEANU 5, NICOLA MONTANO 6, ANCA PANTEA STOIAN 5*, DENISA IOANA UDEANU 7, VIOREL JINGA 8, GABRIELA IORGULESCU 9#, ION-BOGDAN DUMITRESCU 7
1.Department of Internal Medicine, Faculty of Medicine, “Ovidius” University, Constanța, Romania
2.IRCCS MultiMedica, 300 Milanese str, 20099 Sesto San Giovanni MI Milan, Italy
3.Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of South Carolina, Columbia, SC, USA
4.Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy
5.Diabetes, Nutrition and Metabolic Diseases Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
6.Department of Clinical Sciences and Community Health, University of Milano, Italy
7.Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
8.Urology Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
9.Behavioral Sciences Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania -
HYDROXYCHLOROQUINE AND AZITHROMYCIN COMBINATION COULD BE LETHAL TO COVID-19 PATIENTS
FIRDOUS SAYEED MOHAMMAD *, VARNITA KARMAKAR #, ZAINAB IRFAN #
Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah 711316, West Bengal, India
-
THE CHALLENGES OF USING PD-L1 AS A PREDICTIVE BIOMARKER AND THE THERAPEUTIC APPROACH IN NON-SMALL CELL LUNG CANCER IMMUNOTHERAPY
ADELA PĂTCAȘ 1#, CRISTINA MOGOȘAN 2*, TEODORA GABRIELA ALEXESCU 3#, IOANA ROXANA BORDEA 4, ANCA DANA BUZOIANU 5#, DOINA ADINA TODEA 1
1.“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Pneumology, Cluj-Napoca, Romania
2.“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Pharmacology, Physiology and Pathophysiology, Cluj-Napoca, Romania
3.“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Internal Medicine, Cluj-Napoca, Romania
4.“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Oral Rehabilitation, Oral Health and Dental Office Management, Cluj-Napoca, Romania
5.“Iuliu Hațieganu” University of Medicine and Pharmacy, Department of Pharmacology, Toxicology and Clinical Pharmacology, Cluj-Napoca, Romania -
MOLECULAR BACKGROUNDS OF INDIVIDUALISED PHARMACOTHERAPY
MONICA NEAMȚU 1, RĂZVAN NICOLAE RUSU 1, DANIELA CARMEN ABABEI 1*, WALTHER BILD 2,3, CRISTINA GAVRILOVICI 4, BOGDAN STANA 2, VERONICA BILD 1,3
1.“Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmacodynamics and Clinical Pharmacy Department, Iași, Romania
2.“Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Physiology Department, Iași, Romania
3.Center of Biomedical Research of the Romanian Academy, Iași, Romania
4.“Gr. T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Paediatrics Department, Iași, Romania -
NEW APPROACHES OF THE HYPONATREMIA TREATMENT IN THE ELDERLY – AN UPDATE
ALICE BĂLĂCEANU 1,2#, SECIL OMER 1,2, SILVIU ADRIAN MARINESCU 1,3*, SILVIU MIREL PIȚURU 1#, ȘERBAN DUMITRACHE 2#, DANIELA ELENA POPA 1, ANDREEA ANTONIA GHEORGHE 2, SIRAMONA POPESCU 3, CĂTĂLIN BEJINARIU 3, OCTAV GINGHINĂ 1,2, CARMEN GIUGLEA 1,2
1.“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021, Bucharest, Romania
2.“Sf. Ioan” Clinical Emergency Hospital, 13 Vitan-Bârzești Road, 042122, Bucharest, Romania
3.“Bagdasar Arseni” Clinical Emergency Hospital, 12 Berceni Road, 041915, Bucharest, Romania -
THE DEVELOPMENT OF COMPOSITION AND CHARACTERIZATION OF BIODEGRADABLE HEMOSTATIC AND ABSORBABLE SPONGES FOR MEDICAL APPLICATION
BOHDANA PAVLIUK 1*, MARIANA CHUBKA 2, TARAS HROSHOVYI 1
1.Department of Pharmacy Management, Economics and Technology, “I. Horbachevsky” Ternopil National Medical University, Ternopil, Ukraine
2.Department of Pharmacy, Educational Scientific Institute of Postgraduate Education, “I. Horbachevsky” Ternopil National Medical University, Ternopil, Ukraine -
UNDERSTANDING THE MECHANISM OF ACTION OF INTRAVENOUS IMMUNOGLOBULINS: A TEN YEARS EXPERIENCE IN TREATING GUILLAIN BARRÉ SYNDROME
ADINA STOIAN 1,4, ANCA MOTATAIANU 2,4*, LAURA BARCUTEAN 2,4, SMARANDA MAIER 2,4, ZOLTAN BAJKO 2,4, SEPTIMIU VOIDAZAN 3, ANDRADA FARCAS 4, RODICA BALASA 2,4
1.Department of Pathophysiology, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” Târgu Mureş, Romania
2.Department of Neurology, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” Târgu Mureş, Romania
3.Department of Epidemiology, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” Târgu Mureş, Romania
4.Neurology 1 Clinic, Emergency Clinical County Hospital of Târgu Mureş, Romania -
FORMULATION OF ORODISPERSIBLE TABLETS CONTAINING PARACETAMOL AND THEIR IN VITRO CHARACTERIZATION – A QbD APPROACH
ANDREI CĂTĂLIN MUNTEAN 1#, OANA IULIANA NEGOI 1*, LUCA LIVIU RUS 1, ANDREEA LOREDANA VONICA 1#, IOAN TOMUŢĂ 2
1.“Lucian Blaga” University of Sibiu, Faculty of Medicine, Romania
2.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania -
EFFECTS OF UMBELLIPRENIN ON BLOOD PRESSURE IN HIGH-FAT DIET HYPERTENSIVE RATS
MAHMOUD HASHEMZAEI 1#, TALHEH DOUSTI 1, KONSTANTINOS TSAROUHAS 2, GHOLAMREZA BAGHERI 3, TAXIARCHIS KONSTANTINOS NIKOLOUZAKIS 4, RAMIN REZAEE 5,6#, JAFAR SHAHRAKI 1*
1.Department of Pharmacodynamics and Toxicology, School of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
2.Department of Cardiology, University Hospital of Larissa, Larissa, Greece
3.Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran
4.Center of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece
5.Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6.Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran -
IN SILICO AND EXPERIMENTAL STUDIES FOR THE DEVELOPMENT OF NOVEL OXAZOL-5(4H)-ONES WITH PHARMACOLOGICAL POTENTIAL
ELENA VALENTINA ROȘCA 1, THEODORA VENERA APOSTOL 1, MARIANA CARMEN CHIFIRIUC 2, GRAȚIELA GRĂDIȘTEANU PÎRCĂLĂBIORU 2, CONSTANTIN DRĂGHICI 3, LAURA ILEANA SOCEA 1, OCTAVIAN TUDOREL OLARU 4, GEORGE MIHAI NIȚULESCU 5, ELENA MIHAELA PAHONȚU 6, MĂDĂLINA HRUBARU 3, ȘTEFANIA FELICIA BĂRBUCEANU 1*
1.Organic Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.University of Bucharest, Research Institute of the University of Bucharest (ICUB) and Faculty of Biology, Microbiology Department, 1-3 Portocalelor Alley, 060101, Bucharest, Romania
3.“Costin D. Nenițescu” Organic Chemistry Centre of Romanian Academy, 202B Splaiul Independenței Street, 060023, Bucharest, Romania
4.Pharmaceutical Botany and Cell Biology Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
5.Pharmaceutical Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania
6.General and Inorganic Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956, Bucharest, Romania -
THE PREVALENCE OF URINARY TRACT INFECTIONS IN PREGNANCY AND IMPLICATIONS ON FOETAL DEVELOPMENT
OTILIA MICLE #, LIANA ANTAL, PETRONELA NAGHI, OTILIA ȚICA, DANA CARMEN ZAHA *, MIHAELA MIRELA ZDRÎNCA, LUCIANA DOBJANCHI, MONICA SABĂU #, MARIANA MUREȘAN
University of Oradea, Faculty of Medicine and Pharmacy, 1st December Street, Oradea, 410073, Bihor, Romania
-
EXPERIMENTAL STUDY ON THE INFLUENCE OF SULFONAMIDE DRUG RESIDUES FROM HONEY ON BIOCHEMICAL PARAMETERS IN LAB RATS
IONELA DANIELA MORARIU 1#, LILIANA AVASILCĂI 1, MĂDĂLINA VIERIU 1#, IONUȚ IULIAN LUNGU 1, BOGDAN HUZUM 1, DENISA BATIR MARIN 2, LĂCRĂMIOARA ȘERBAN 1, MONICA HĂNCIANU 1*, OANA CIOANCĂ 1
1.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, 16 Universității Street, 700115, Iași, Romania
2.“Dunarea de Jos” University, Faculty of Medicine and Pharmacy, 35 Al. I. Cuza Street, Galați, Romania -
THE PROTECTIVE EFFECT AND THE UNDERLYING MECHANISM OF EPHEDRA SINICA STAPF ON RENAL INJURY IN A MURINE MODEL
XUE WANG 1,2#, WEI FU 3#, HAIYANG LIU 1, ZHIBIN WANG 2, HAIXUE KUANG 2, QIUHONG WANG 4*
1.Jiamusi College, Heilongjiang University of Traditional Chinese Medicine, Jiamusi, 154002, China
2.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, 150040, China
3.Cavity Mirror Chamber, Jiamusi Cancer Hospital, Jiamusi, 154002, China
4.College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 511470, China -
THE PRESENCE OF PERIPHERAL INFLAMMATORY MARKERS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER, THE ASSOCIATED SYMPTOMS PROFILES AND THE ANTIDEPRESSANT EFFICACY OF CELECOXIB
VIRGIL RADU ENĂTESCU 1,2, RALUKA KALINOVIĆ 2, GABRIELA VLAD 2, LAURA ALEXANDRA NUSSBAUM 1, LAVINIA HOGEA 1, ILEANA ENĂTESCU 1*, ILEANA MARINESCU 3, PETRU IFTENI 4, MIHAELA SIMU 1, CĂTĂLIN MARIAN 1, CĂTĂLINA GIURGI-ONCU 1,2, ION PAPAVĂ 1,2
1.”Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania
2.”Pius Brînzeu” Emergency County Hospital, Psychiatric Clinic, Timișoara, Romania
3.University of Medicine and Pharmacy, Craiova, Romania
4.Transilvania University, Brașov, Romania -
HETEROCYCLES 47. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NEW THIAZOLE AURONES AS ANTIPROLIFERATIVE AGENTS
FANA-MARIA COMAN 1, ARMELLE T. MBAVENG 2,3, GABRIEL MARC 4, DENISA LEONTE 1, BALÁZS BRÉM 5, LAURIAN VLASE 6, SILVIA IMRE 7, VICTOR KUETE 2,3, VALENTIN ZAHARIA 1*
1.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, 41 Victor Babeș Street, 400012, Cluj-Napoca, Romania
2.“Johannes Gutenberg” University, Institute of Pharmacy and Biochemistry, Department of Pharmaceutical Biology, Stawdenger Weg 5, 55128, Mainz, Germany
3.University of Dschang, Faculty of Science, Department of Biochemistry, Cameroon
4.“Iuliu Haţieganu” University of Medicine and Pharmacy, Department of Pharmaceutical Chemistry, 8 Victor Babeș Street, 400012, Cluj-Napoca, Romania
5.“Babeş-Bolyai” University, Faculty of Chemistry and Chemical Engineering, 11 Arany János Street, 400028, Cluj-Napoca, Romania
6.“Iuliu Haţieganu” University of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, 41 Victor Babeș Street, 400012, Cluj-Napoca, Romania
7.University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Department of Analytical Chemistry and Drug Analysis, 38 Gheorghe Marinescu Street, 540139, Târgu Mureș, Romania -
STABILITY AND RHEOLOGICAL PROPERTIES OF NOURIVAN(TM)/ANTIOX(R) BASE WITH SELECTED SOLVENTS
BEATA SZULC-MUSIOŁ 1*, LUCYNA BUŁAŚ 1, BARBARA DOLIŃSKA 1, JUSTYNA KOŁODZIEJSKA 2
1.Department of Pharmaceutical Technology, School of Pharmacy and Division of Laboratory Medicine, Medical University of Silesia, Katowice, Poland
2.Department of Applied Pharmacy, Medical University of Łódź, Poland -
ANTIBIOTIC RESISTANCE IN COMMUNITY-ACQUIRED PNEUMONIA. A ROMANIAN PERSPECTIVE
IONUȚ EMILIAN BLEJAN 1#, CAMELIA CRISTINA DIACONU 2#, ANDREEA LETIȚIA ARSENE 1, DENISA IOANA UDEANU 1#, MANUELA GHICA 1*, DOINA DRĂGĂNESCU 1, GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU 1, MIHAELA RĂDULESCU 3, HELENA C. MALTEZOU 4, ARISTIDES M. TSATSAKIS 5, MARIA PAPASAVVA 6, NIKOLAOS DRAKOULIS 6, DANIELA ELENA POPA 1
1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Clinical Emergency Hospital of Bucharest, Romania
3.University of Economic Studies, Bucharest, Romania
4.National Public Health Organization, 15123, Athens, Greece
5.University of Crete, Medical School, Department of Toxicology and Forensic Sciences, 74100, Rethymno, Greece
6.Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771, Zografou, Greece -
CYTOTOXIC AND PHYTOCHEMICAL INVESTIGATION OF COUSINIA ERMENEKENSIS HUB.-MOR.
LEYLA PAŞAYEVA 1*, EREN DEMİRPOLAT 2, HANİFA FATULLAYEV 3, OSMAN TUGAY 4
1.Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
2.Department of Pharmacology, Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
3.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38030, Turkey
4.Department of Pharmaceutical Botany, Faculty of Pharmacy, Selçuk University, Konya 42250, Turkey -
THE IMPACT OF THE LUBRICATION STEP WITH MAGNESIUM STEARATE ON THE QUALITY TARGET PRODUCT PROFILE OF A MODIFIED RELEASE ORAL DOSAGE FORM CONTAINING A BCS CLASS II ACTIVE PHARMACEUTICAL INGREDIENT
PAUL ANCU DUMITRAȘCU 1,2, CRISTINA GABRIELA STECOZA 2,3, MARILENA GAVRILESCU 2, CARMEN ALECSANDRESCU 2, ALINA IVANCENCU 2, VALENTINA ANUȚA 1*, LACRĂMIOARA POPA 1, MIHAELA VIOLETA GHICA 1, CRISTINA ELENA DINU-PÎRVU 1
1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Physical and Colloidal Chemistry, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.Zentiva S.A., Portofolio Strategy and Investment Department, 50 Theodor Pallady Boulevard, 032266, Bucharest, Romania
3.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Center for Drug Sciences, 6 Traian Vuia Street, 020956, Bucharest, Romania -
NEW ISONIAZID DERIVATIVES FOR ANTIMICROBIAL SPECTRUM EXTENSION AND HEPATOTOXICITY REDUCTION OF PARENT COMPOUND: IN VITRO AND IN VIVO ASSAYS
OANA-MARIA DRAGOSTIN 1#, IONUȚ DRAGOSTIN 2#, ALEXANDRA-SIMONA ZAMFIR 2, LUMINIȚA CONFEDERAT 3#, CĂTĂLINA DANIELA STAN 4*, MARIA DRĂGAN 4, CRISTINA TUCHILUȘ 3, CARMEN LĂCRĂMIOARA ZAMFIR 2
1.Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, 47 Domnească Street, 800010, Galați, România
2.Department of Morpho-Functional Sciences I, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universității Street, 700115, Iași, România
3.Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universității Street, 700115, Iași, România
4.Department of Pharmaceutical Sciene II, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universității Street, 700115, Iași, România -
EVIDENCE-BASED USE OF SEA BUCKTHORN FRESH JUICE FOR PATIENTS WITH TRAUMATIC BRAIN INJURY. A PILOT STUDY
CONSTANTIN SORIN GODEANU 1, TEODORA COSTEA 2*, MANUELA GHICA 2, DUMITRU LUPULIASA 2, CERASELA ELENA GÎRD 2
1.Department of Anaesthesia and Intensive Care Unit, “Floreasca” Emergency Clinical Hospital, 014461, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 020956 Bucharest, Romania -
THE EFFICACY OF COENZYME Q10 IN COMBINATION WITH ATORVASTATIN ON CORONARY HEART DISEASE
YUANYUAN WANG 1, ZHILI QIAO 2, TINGTING LU 1, KUN LI 1*
1.Department of Cardiology, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011, China
2.Department of Emergency, Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, 157011, China -
MANAGEMENT OF THE BOVINE TUBERCULOSIS DIAGNOSTIC IN ROMANIAN FARMS, IN THE LIGHT OF THE MULTIDRUG-RESISTANT TUBERCULOSIS EMERGENCE
FLORICA BĂRBUCEANU 1,2#, DANIELA STAMATE 1,2*, STELIAN BĂRĂITĂREANU 2#, MARIA IONESCU 1, GABRIEL PREDOI 2
1.Institute for Diagnosis and Animal Health, 63 Dr. Staicovici D. Nicolae Street, 050557, Bucharest, Romania
2.University of Agricultural Science and Veterinary Medicine, Faculty of Veterinary Medicine, 105 Splaiul Independentei, 050097, Bucharest, Romania -
PHYSICO-CHEMICAL CHARACTERIZATION OF IGALO BAY PELOID (MONTENEGRO) AND ASSESSMENT OF THE POLLUTION OF POTENTIALLY TOXIC ELEMENTS IN THE SAMPLING AREA
MILJAN BIGOVIC 1*, MILOVAN ROGANOVIC 2, IVANA MILASEVIC 3, DIJANA DJUROVIC 3, VJEROSLAVA SLAVIC 4, MILICA KOSOVIC 5, MIA VLAHOVIC 5, SVETLANA PEROVIC 1, ANDREJ PEROVIC 1, VLATKO KASTRATOVIC 1, ZORICA POTPARA 2, MILICA MARTINOVIC 2, SNEZANA PANTOVIC 2
1.University of Montenegro, Faculty of Natural Sciences and Mathematics, G. Washington Boulevard, 81000, Podgorica, Montenegro
2.University of Montenegro, Faculty of Medicine, Kruševac, 81000, Podgorica, Montenegro
3.Institute for Public Health of Montenegro, Ljubljanskaa, 81000, Podgorica, Montenegro
4.Institute “Dr Simo Milosevic” Igalo, 5 Sava Ilica, 85347, Igalo, Herceg Novi, Montenegro
5.University of Montenegro, Faculty for Technology and Metallurgy, G. Washington Boulevard, 81000, Podgorica, Montenegro -
THE REAL-WORLD COST AND EFFECTIVENESS STUDY OF TREATING mCRC WITH BEVACIZUMAB FOLLOWED BY CETUXIMAB OR PANITUMUMAB IN WT KRAS PATIENTS
IRENA SEHNALOVA 1, BARBORA RIHOVA 1*, RADIM NEMECEK 2, KATERINA KINTROVA 3, REGINA DEMLOVA 1,2
1.Department of Pharmacology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
2.Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic
3.Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic