Romanian Society of Pharmaceutical Sciences
 

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EVIDENCE-BASED USE OF SEA BUCKTHORN FRESH JUICE FOR PATIENTS WITH TRAUMATIC BRAIN INJURY. A PILOT STUDY

CONSTANTIN SORIN GODEANU 1, TEODORA COSTEA 2*, MANUELA GHICA 2, DUMITRU LUPULIASA 2, CERASELA ELENA GÎRD 2

1.Department of Anaesthesia and Intensive Care Unit, “Floreasca” Emergency Clinical Hospital, 014461, Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 020956 Bucharest, Romania

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Sea buckthorn (Hippophaë rhamnoides L.) berries are widely used for their nutrional value and therapeutic effects. The aim of our paper was the evolution of phenolic content (by means of spectrophotometric methods), antioxidant capacity (scavenger activity towards DPPH, ABTS·+ free radicals and ferric reducing power) and evidence regarding sea buckthorn fresh juice association in the management of hospitalized patients with traumatic brain injury. According to our results, sea buckthorn fresh juice is a source of phenolic compounds (0.28 g total phenolic content expressed as tannic acid equivalents/100 mL fresh juice and 0.09 g flavones expressed as hyperoside equivalents/100 mL fresh juice), with antioxidant activity. Our clinical results have shown beneficial effects (a decrease in lactate and sodium blood levels and an increase in Glasgow coma score) of sea buckthorn fresh juice (given together with specific medication) in the management of patients with traumatic brain injury.