EXPERIMENTAL STUDY ON THE INFLUENCE OF SULFONAMIDE DRUG RESIDUES FROM HONEY ON BIOCHEMICAL PARAMETERS IN LAB RATS
IONELA DANIELA MORARIU 1#, LILIANA AVASILCĂI 1, MĂDĂLINA VIERIU 1#, IONUȚ IULIAN LUNGU 1, BOGDAN HUZUM 1, DENISA BATIR MARIN 2, LĂCRĂMIOARA ȘERBAN 1, MONICA HĂNCIANU 1*, OANA CIOANCĂ 1
1.“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, 16 Universității Street, 700115, Iași, Romania
2.“Dunarea de Jos” University, Faculty of Medicine and Pharmacy, 35 Al. I. Cuza Street, Galați, Romania
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The objective of the research was the study on the influence of five sulfonamides residues (sulfadiazine, sulfamethazine, sulfathiazole, sulfamethizole, and sulfadimethoxine) in bee honey administered on Wistar rats, by evaluating various biochemical parameters (urea, creatinine, uric acid, total bilirubin, direct bilirubin and transaminases). The biochemical parameters presented significant variations and the results confirmed the occurrence of known toxic effects when administering the five sulfonamides from bee honey in rats: liver dysfunction through the permeabilization of the hepatocyte membrane, and the impairment of hepato-biliary and renal functions.