Farmacia Journal 3/2024
Volume 72 | Number 3 | Year 2024
Download this issue’s covers, and announcements.
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SUNSCREEN TOPICAL PRODUCTS – FROM CONVENTIONAL TO NOVEL FORMULATIONS
MIHAELA AFRODITA DAN 1, ANCUȚA CĂTĂLINA FIȚA 1, GEORGIANA NIȚULESCU 1*, EMMA ADRIANA OZON 1, EMILIA STANCU 2, MIHAELA DANIELA BALTĂ 3, TEODORA BALACI 1, DUMITRU LUPULIASA 1, IOANA ANDREEA POPESCU 1
1“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, 6 Traian Vuia Street, 020945, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Management and Marketing, 6 Traian Vuia Street, 020945, Bucharest, Romania
3“Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine, Department of Family Medicine, 8 Eroii Sanitari Boulevard, 050474, Bucharest, Romania -
INVESTIGATING THE PHYSICOCHEMICAL, NON-CLINICAL, AND CLINICAL CRITERIA FOR ASSESSING COMPARABILITY IN RANIBIZUMAB BIOSIMILARS: A COMPREHENSIVE REVIEW
AMMAR ALMAAYTAH*
Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
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ASSESSMENT OF RELATIVE BIOAVAILABILITY OF TWO INDAPAMIDE TABLET FORMULATIONS AFTER ADMINISTRATION OF SINGLE DOSES TO FASTED CAUCASIAN SUBJECTS IN 2-WAY CROSSOVER STUDY
MARIA CODREANU 1,2, DIANA IACOB 3, ANA-MARIA VLASE 4*, DANA MARIA MUNTEAN 1, LAURIAN VLASE 1
1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Regulatory Affairs Department, Antibiotice SA, Iași, Romania
3Centre for Drug Evaluation, Antibiotice SA, Iași, Romania
4Department of Pharmaceutical Botany, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania -
EFFECTS OF H4415 ON PAIN SENSITIVITY IN RAT
AURELIA MÂRZA 1, CĂTALIN CEZAR CĂRĂTAŞU 1, ANDREI CIOBICĂ 1*, VERONICA BILD 1,2, ALEXANDRU VASINCU 1, RĂZVAN-NICOLAE RUSU 1, BOGDAN IONEL TAMBA 1,3, WALTHER BILD 1,2
1Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania
2Center of Biomedical Research, Romanian Academy, Iași branch, Romania
3Advanced Center for Research and Development in Experimental Medicine, Prof. Ostin C. Mungiu", CEMEX, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania -
IN VITRO BIOCOMPATIBILITY AND IN OVO IRRITANT POTENTIAL SCREENING OF TWO CLEAR ALIGNERS WITH ORTHODONTIC APPLICATIONS
STEFANIA DINU 1,2#, OLTEANU NICOLAE DANIEL 3#, ANAMARIA MATICHESCU 4,5*, ZETU IRINA NICOLETA 6, CAMELIA SZUHANEK 7,8, ANDREEA GEAMANTAN 9,10, ALEXANDRA- DENISA SEMENESCU 9,10, ALINA ANTON 9,10, ROXANA BUZATU 11
1Department of Pedodontics, Faculty of Dental Medicine, “Victor Babeș” University of Medicine and Pharmacy Timisoara, 9 Revoluției 1989 Boulevard, 300041, Timișoara, Romania
2Pediatric Dentistry Research Centre, Faculty of Dental Medicine, “Victor Babeș” University of Medicine and Pharmacy Timisoara, 9 Revoluției Boulevard, 300041, Timișoara, Romania
3“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iași, Romania
4Department of Preventive, Community Dentistry and Oral Health, Dental Medicine, “Victor Babeș” University of Medicine and Pharmacy Timisoara, 14A Tudor Vladimirescu Avenue, 300173, Timișoara, Romania
5Translational and Experimental Clinical Research Centre in Oral Health, “Victor Babeș” University of Medicine and Pharmacy Timisoara, 14A Tudor Vladimirescu Avenue, 300173, Timișoara, Romania
6Department of Orthodontics, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iași, Romania
7Department of Orthodontics, Faculty of Dental Medicine, “Victor Babeş” University of Medicine and Pharmacy Timisoara, 9 No., Revolutiei Bv., 300041 Timişoara, Romania
8Orthodontic Research Centre (ORTHO-CENTER), “Victor Babeș” University of Medicine and Pharmacy Timișoara, Timișoara, Romania
9Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
10Research Centre for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 2 Eftimie Murgu Square, 300041, Timișoara, Romania
11Department of Dental Aesthetics, Faculty of Dental Medicine, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 9 Revoluției Boulevard, 300041, Timișoara, Romania -
THE ANTI-AGEING POTENTIAL OF LITSEA OPPOSITIFOLIA STEM EXTRACT: EVIDENCE FROM IN VITRO AND EX VIVO STUDY ON SKIN CELL LINES
DONNA MARETTA ARIESTANTI 1 , BERNA ELYA 1*, PIETRADEWI HARTRIANTI 2 , VIVIAN CHERISA ARIFIN 2 , CRISSHELLA HANA 2 , PATRICIA LOVINA 2 , REDHALFI FADHILA 1
1Faculty of Pharmacy, University Of Indonesia, Depok 16424, Indonesia
2Indonesia International Institute For Life Sciences, East Jakarta 13210, Indonesia -
INVESTIGATION OF ANTIMICROBIAL ACTIVITY AND RHEOLOGICAL PROPERTIES OF CHITOSAN- AND ALGINATE- BASED HYDROGELS ENRICHED WITH VOLATILE OILS FOR BIOMEDICAL APPLICATIONS
FLORIN ALEXANDRU JOIȚA 1#, MAGDALENA MITITELU 1#, ADINA MAGDALENA MUSUC 2#, ELIZA OPREA 3*, FLORICA MARINESCU 3, DUMITRU LUPULIASA 1, LUCIAN HÎNCU 1, TEODOR OCTAVIAN NICOLESCU 1, ANCA LUCIA POP 1, IOANA ANDREEA POPESCU 1
1Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 020956, Bucharest, Romania
2Institute of Physical Chemistry – Ilie Murgulescu, Romanian Academy, 060021, Bucharest, Romania
3Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Portocalilor Street, 060101, Bucharest, Romania -
INFLUENCE OF DUAL-RESPONSIVE OXALIPLATIN (L-OHP)-/ NARINGIN (NAR) DRUG DELIVERY SYSTEM ON THE GROWTH OF COLORECTAL TUMORS AND THE IMMUNE MICROENVIRONMENT
WENQIN LI, CHUANXIN ZOU*
Department of Gastroenterology, Jingzhou Central Hospital, Yangtze University, Jingzhou, 434020, Hubei, China
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BENEFITS OF SEA BUCKTHORN FRUIT OIL AS ADJUVANT THERAPY IN RHEUMATOID ARTHRITIS
GEORGETA STEFANOVICI ZUGRAVU 1,2, DANIELA CRISTINA DIMITRIU 3, CORINA PARASCHIVA CIOBANU 3, BOGDAN IONEL TAMBA 3,4, MITICA CIORPAC 4, COSMIN- TEODOR MIHAI 4,5, CARMEN-MARINELA CUMPAT 2,3, MIHAI BREBU 6, ALEXANDRU MANDICI 1, ALINA DIANA PANAINTE 1, ADRIANA TRIFAN 1, ANCA MIRON 1*
1Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 16, Universitatii Str., 700115, Iasi, Romania
2Clinical Rehabilitation Hospital, 14, Pantelimon Halipa Str., 700661, Iasi, Romania
3Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16, Universitatii Str., 700115, Iasi, Romania
4Advanced Research and Development Centre for Experimental Medicine (CEMEX), Grigore T. Popa University of Medicine and Pharmacy, 9-13, Mihail Kogalniceanu Str., 700259, Iasi, Romania
5Medical Investigations Praxis SRL, 35, Moara de Vant Str., 700376, Iasi, Romania
6Laboratory of Physical Chemistry of Polymers, Petru Poni Institute of Macromolecular Chemistry, 41A, Grigore Ghica Voda Al., 700487, Iasi, Romania -
RFA-INDUCED ALTERATIONS IN THE EXPRESSION OF PD-1 AND CTLA-4 IN THE TUMOUR MICROENVIRONMENT pCCA: RESULTS FROM AN EXPLORATORY STUDY
BIANCA GĂLĂȚEANU 1#, OCTAV GINGHINĂ 2,3#, ARIANA HUDIȚĂ 1,4*, RALUCA-SILVANA TUDORACHE 5, MARIUS-COSMIN ZAMFIR 3,6, MARA MARDARE 3,6, CLAUDE LAMBERT 7, MIHAELA BÎRLIGEA 8,9, CLAUDIA DIACONU 8, CRISTIANA POPP 8,9, GEORGE-TRAIAN- ALEXANDRU BURCEA-DRAGOMIROIU 10, ANDREI VOIOSU 8,9, THEODOR VOIOSU 8,9
1Faculty of Biology, University of Bucharest, Bucharest, Romania
2Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3Department of Surgery 3, “Prof. Dr. Al. Trestioreanu” Institute of Oncology, Bucharest, Romania
4Research Institute of the University of Bucharest, University of Bucharest, Bucharest, Romania
5The University of York, York, United Kingdom
6Doctoral School of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
7Central University Hospital Saint-Etienne, Saint-Etienne, France
8Gastroenterology Department, Colentina Clinical Hospital, Bucharest, Romania
9Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
10Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania -
THE CORRELATION BETWEEN NUTRITIONAL STATUS AND MUSCLE STRENGTH, AND DYNAMOMETRY IN PATIENTS WITH LIVER CIRRHOSIS IN IRAQ
AMAL MAYYAS 1 , OMAR D. SALMAN 2 , ALI YOUSIF NORI 3 , ALI MAHMOUD ALSAMYDAI 4 , ZAHRAA SALAM AL-TAMEEMI 5 , HANY A. AL-HUSSANIY 5,6*
1Faculty of Health Sciences, American University of Madaba, Madaba, Jordan
2Faculty of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq
3Department of Pharmacy, AL Mustafa University College, Baghdad, Iraq
4Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan
5Dr Hany Akeel institute, Iraqi Medical Research Centre, Baghdad, 10001, Iraq
6Department of Pharmacy, Damascus University, Syria -
OUTCOME OF CO-ADMINISTRATION OF SEA BUCKTHORN FRUIT IN HIGH FAT DIET WISTAR RATS
OLIVIA TIMNEA 1, BOGDANA VIRGOLICI 2*, ELVIRA GAGNIUC 3, MARIA MOHORA 2, DANIELA MIRICESCU 2, DANIELA GRADINARU 2, IULIA STANESCU-SPINU 2, MARIA DOBRE 2
1Romano-American University, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3University of Agronomic Sciences and Veterinary Medicine, Bucharest, Romania -
THERAPEUTIC STRATEGIES AND USE OF LOPINAVIR/RITONAVIR IN PATIENTS WITH HIGHLY RESISTANT HUMAN IMMUNODEFICIENCY VIRUS
ZHONG CHEN 1, 3, TONG WANG 2, CAIHONG WU 2, KEJI DENG 2, MIN WANG 3, HUI QI 3, NING WANG 3, YING LI 3, YONG DENG 3, GUIYING CAO 3, SHENGMING LIU 1*
1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China
2MOE Key Laboratory of Tumour Molecular Biology, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China
3Department of Infection and Immunology, The First Hospital of Changsha City, Changsha, 410000, Hunan, China -
A QUALITY BY DESIGN APPROACH TO OPTIMISE THE TRANSFECTION EFFICIENCY OF POLY(AMIDOAMINE)-BASED NANOPARTICLES WITH mRNA
SAKETH REDDY RANAMALLA 1, 2, ALINA SILVIA PORFIRE 2*, MANUELA BANCIU 3#, IOAN TOMUȚA 2#
1Doctoral School in Integrative Biology, Faculty of Biology and Geology, “Babeș-Bolyai” University, 400015 Cluj-Napoca, Romania
2Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Hațieganu”, 400010, Cluj-Napoca, Romania
3Department of Molecular Biology and Biotechnology, Centre of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, “Babeș-Bolyai” University, 400015 Cluj-Napoca, Romania -
PHYTOCHEMICAL PROFILING BY LC-HRMS AND ANTIOXIDANT ACTIVITY OF BLUMEA BALSAMIFERA LEAVES EXTRACT BASED ON DIFFERENCES IN THE GROWING LOCATION AND EXTRACTING SOLVENT
RUDI HERYANTO 1,2, ZULAEHA 3, WENI ANINDYA 1, LENY HELIAWATI 3 , DEWI ANGGRAINI SEPTANINGSIH 4, ALFI HUDATUL KAROMAH 1, TRIVADILA 1,2, MIN RAHMINIWATI 2,5 , DYAH ISWANTINI 1,2*, MOHAMAD RAFI 1,2,4
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Jalan Tanjung Kampus IPB Dramaga, Bogor 16880, Indonesia
2Tropical Biopharmaca Research Centre, Institute of Research and Community Services, IPB University, Jalan Taman Kencana No. 3 Kampus IPB Taman Kencana, Bogor 16128, Indonesia
3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Pakuan University, Bogor 16143, Indonesia
4Advance Research Laboratory, IPB University, Jalan Palem Kampus IPB Dramaga, Bogor 16680, Indonesia
5Division of Pharmacology, Department of Anatomy, Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Kampus IPB Dramaga, Bogor, Indonesia -
GENISTEIN AND QUERCETIN TRIGGER CYTOTOXICITY, APOPTOSIS, AND OXIDATIVE STRESS IN SK-MEL-28 CUTANEOUS MELANOMA CELLS
ANDREA ROMAN 1,2,#, IASMINA MARCOVICI 3,4,#, RAUL CHIOIBAȘ 2,5*, ANDREI MOTOC 2, GEORGE PUENEA 2, ZSOLT GYORI 2, ZORIN CRĂINICEANU 2, DIANA CAMELIA BONTE 2
1Faculty of Medicine, "Vasile Goldiș" Western University of Arad, 94 Revolutiei Blvd., 310130, Arad, Romania
2Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square 2, 300041, Timișoara, Romania
3Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square 2, 300041, Timișoara, Romania
4Research Centre for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square 2, 300041, Timișoara, Romania
5CBS Medcom Hospital, 12th Popa Sapca Street, 300047 Timisoara, Romania -
FLAVONOID-RICH EXTRACT OF VARTHEMIA IPHIONOIDES INCREASED LOW-DENSITY LIPOPROTEIN RECEPTOR AND DECREASED HYDROXYMETHYLGLUTARYL COA REDUCTASE EXPRESSION IN HEPG2 CELLS
MANAL M. ABBAS 1, MANAL A. ABBAS 1, WAEL MOHAMEDY AFIFI 2,3, YASSER IBRAHIM KANDIL 4,5*
1Department of Medical Lab. Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan
2Pharmacognosy Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
3Pharmacognosy Department, Faculty of Pharmacy, Sinai University – Kantara Branch, Ismailia, Egypt
4Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
5Biochemistry Department, Faculty of Pharmacy, Sinai University – Kantara Branch, Ismailia, Egypt -
HLA HAPLOTYPES AND THE RISK OF SEVERE GLYCAEMIC ONSET IN NEWLY DIAGNOSED TYPE 1 DIABETIC PATIENTS FROM ROMANIA: A SINGLE-CENTRE PILOT COHORT STUDY
AMALIA-IOANA ARHIRE 1,2, SORIN IOACĂRĂ 1,2*, TEODORA PAPUC 2, MIRUNA SÂNZIANA CHIPER 2, IRINA MONICA DUȚESCU 3, ANA MOISE 3, IOANA BADEA 3, SUZANA FLOREA 4, SIMONA FICA 1,2
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2Department of Endocrinology, Diabetes, Nutrition and Metabolic diseases, Elias Hospital, 011461, Bucharest, Romania
3HLA Laboratory, “C.T. Nicolau” National Institute of Blood Transfusion, 011154, Bucharest, Romania
4The Immunology Laboratory, Elias Hospital, 011461, Bucharest, Romania -
ACUTE AND SUBACUTE TOXICITY STUDY OF LAPORTEA DECUMANA LEAF EXTRACT IN RATS
YASMIN GHALLYAH HASAN 1 , YULIA YUSRINI DJABIR2*, GEMINI ALAM 3,5, M. ARYADI ARSYAD 4 , NURHAQ YULIARDA 2 , MUSDALIFAH MUSDALIFAH 2 , HAMDAYANI DWI PUTRI 2 , INDAH SYAFIRA BASRI 2 , DJULFIKRI MEWAR 1
1Graduate Program, Magister of Pharmacy Program, Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
2Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
3Laboratory of Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
4Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia
5Drug Discovery and Development Research Center of Hasanuddin University, Makassar, 90245, Indonesia -
DIABETIC FOOT CARE RECOMMENDATIONS – PATIENT BEHAVIOURAL TRENDS
ALINA ANDREA MORARU 1#, DANIELA CARMEN ABABEI 1, ALEXANDRU VASINCU 1*, RĂZVAN NICOLAE RUSU 1#, MONICA NEAMȚU 1, OANA ARCAN 1, VLAD CONSTANTIN CRĂCIUN 3, IOANA MACADAN 1, VERONICA BILD 1,2
1Department of Pharmacodynamics and Clinical Pharmacy,”Grigore T. Popa” University of Medicine and Pharmacy of Iași
2Center for Biomedical Research, Romanian Academy, Iași Branch
3Department of Computer Science,”Alexandru Ioan Cuza” University of Iași -
ASSOCIATION OF NFE2L2 GENE POLYMORPHISM (rs35652124) WITH DEVELOPMENT OF RETINOPATHY IN IRAQI TYPE 2 DIABETIC PATIENTS, IN RELATION TO VASCULAR ENDOTHELIAL GROWTH FACTOR AND ENDOCAN SERUM LEVELS
SARAH HASHIM MHAIBES 1*, SHATHA H ALI 1
1Clinical Laboratory Sciences Department, College of Pharmacy, University of Baghdad, Iraq
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QUALITY OF LIFE OF ROMANIAN PATIENTS WITH SENSITIVE AND DRUG-RESISTANT TUBERCULOSIS DURING AND AFTER TREATMENT
TEODORA BUTNARU 1,2*, FLORIN DUMITRU MIHALTAN 1,2, ANCUTA ALINA CONSTANTIN 1,2
1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2“Marius Nasta” Institute of Pneumology, Bucharest, Romania -
POTENTIALLY INAPPROPRIATE PRESCRIBING IN ELDERLY PATIENTS ACROSS HEALTHCARE SETTINGS: APPLICATION OF STOPP/START VERSION 2 CRITERIA
KOVAČEVIĆ MILENA 1*, CATIĆ-ĐORĐEVIĆ ALEKSANDRA 2, JOVANOVIĆ MARIJA 1, ĆULAFIĆ MILICA 1, STEFANOVIĆ NIKOLA 2, MITIĆ BRANKA 3,4, VUČIĆEVIĆ KATARINA 1, VEZMAR KOVAČEVIĆ SANDRA 1, VELIČKOVIĆ-RADOVANOVIĆ RADMILA 3,4, MILJKOVIĆ BRANISLAVA 1
1University of Belgrade - Faculty of Pharmacy, Department of Pharmacokinetics and Clinical Pharmacy, Vojvode Stepe 450, 11221, Belgrade, Republic of Serbia
2University of Niš - Faculty of Medicine, Department of Pharmacy, Dr Zorana Đinđića 81 Blvd., 18000, Niš, Republic of Serbia
3University of Niš - Faculty of Medicine, Department of Pharmacology with Toxicology, Dr Zorana Đinđića 81 Blvd., 18000, Niš, Republic of Serbia
4University Clinical Center Niš, Clinic of Nephrology, Dr Zorana Đinđića 48 Blvd., 18000, Niš, Republic of Serbia -
QUANTIFYING THE QUALITY OF SERVICES IN COMMUNITY PHARMACIES IN ROMANIA – DESIGNING AND APPLYING A QUESTIONNAIRE AMONG PHARMACEUTICAL STAFF
ETIDAL-MIHAELA MANOLIU-HAMWI, CRISTINA GENA DASCĂLU, GEORGETA ZEGAN *, ELENA-MIHAELA CĂRĂUȘU, CĂTĂLINA DANIELA STAN
“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania
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EXPLORING THE CONSCIENCE CLAUSE FOR PHARMACISTS IN THE EU COUNTRIES
OFELIA CRIŞAN, ALEXANDRA TOMA *
Department of Pharmaceutical Legislation and Management, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania