Farmacia Journal 3/2015

Volume 63 | Number 3 | Year 2015

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THE CURRENT INSIGHT ON DUAL RENIN-ANGIOTENSIN SYSTEM BLOCKADE: A DATA REVIEW WITH A FOCUS ON

ANDREEA FARCAȘ¹, FELICIA GLIGOR^2*, CAMELIA BUCȘA¹, CRISTINA MOGOȘAN¹, MARIUS BOJIȚĂ¹, DAN DUMITRAȘCU³

1.Iuliu Hațieganu University of Medicine and Pharmacy, Drug Information Research Center, Pasteur 6, 400349, Cluj-Napoca, Romania
2.Lucian Blaga University Sibiu, Faculty of Medicine, Lucian Blaga, 2A, 550169, Sibiu, Romania
3.Iuliu Hațieganu University of Medicine and Pharmacy, 2nd Medical Department, Clinicilor 2-4, 400013, Cluj-Napoca, Romania

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QUALITATIVE AND QUANTITATIVE CHEMICAL STUDY OF RUSSULA VIRESCENS MUSHROOM

MARIA LIDIA POPESCU^1*, MIHAELA CULMEŞ², CERASELA ELENA GÎRD¹

1.University of Medicine and Pharmacy “Carol Davila“, Faculty of Pharmacy, 6 Traian Vuia street, Bucharest, Romania
2.Department of Traumatology, Technical University Munich, Klinikum rechts der Isar, Ismaninger str.22, 81675, Munich, Germany

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INHIBITION OF STREPTOCOCCUS PNEUMONIAE AND ESCHERICHIA COLI ADENYLATE KINASE BY 2-AMINO-4-METHYL-N'-ARYLIDENETHIAZOLE- 5-CARBOHYDRAZIDES

MIHAELA IONESCU^1*, ADRIANA ZOE RĂDULESCU², SMARANDA ONIGA³, HORIA LEONARD BANCIU⁴, IULIA LUPAN⁵

1.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Medicine, Department of Microbiology, 6 Pasteur Street, 400349, Cluj-Napoca, Romania
2.Cantacuzino Institute, Enzymology and Applied Microbiology Laboratory, 103 Splaiul Independentei Street, 050096, Bucharest, Romania
3.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Therapeutic Chemistry, 12 Ion Creanga Street, 400010, Cluj-Napoca, Romania
4.Babeş-Boyai University, Faculty of Biology and Geology, Department of Experimental Biology, 5-7 Clinicilor Street, 400006, Cluj-Napoca, Romania
5.Babeş-Boyai University, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, 42 Treboniu Laurian Street, 400271, Cluj-Napoca, Romania

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EVALUATION OF THE ANDROGENIC/ANTIANDROGENIC ACTIVITY OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS

ANCA POP, DIANA LUPU^*, JULIEN CHERFAN, BELA KISS, FELICIA LOGHIN

“Iuliu Haţieganu” University of Medicine and Pharmacy, Department of Toxicology, Faculty of Pharmacy, Cluj-Napoca, Romania

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QUANTITATIVE RELATIONSHIPS OF URINARY COTININE LEVELS IN SMOKING DIABETIC PATIENTS

ANA MARIA VLĂSCEANU¹, CONSTANTIN PETRARU¹, DANIELA BACONI^1*, MIHAELA GHICA², ANDREEA ARSENE³, LĂCRĂMIOARA POPA², ALINA NICOLAE³, CRISTINA DRĂGOI³, GEORGETA PAVALACHE⁴

1.University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Toxicology, Traian Vuia 6, Bucharest, Romania
2.University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Physical and Colloidal Chemistry, Traian Vuia 6, Bucharest, Romania
3.University of Medicine and Pharmacy “Carol Davila”, Faculty of Pharmacy, Department of Biochemistry, Traian Vuia 6, Bucharest, Romania
4.”Ovidius” University Constanta, Faculty of Pharmacy, Constanţa, Romania

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ANTIMICROBIAL ACTIVITY AND CHEMICAL COMPOSITION OF THYME ESSENTIAL OILS AND THE POLYPHENOLIC CONTENT OF DIFFERENT THYMUS EXTRACTS

ERZSÉBET VARGA^1*, ANNA BARDOCZ¹, ÁGNES BELÁK², ANNA MARÁZ², BORBÁLA BOROS³, ATTILA FELINGER³, ANDREA BÖSZÖRMÉNYI⁴, GYÖRGYI HORVÁTH⁵

1.University of Medicine and Pharmacy of Tg. Mureş, Faculty of Pharmacy, Department of Pharmacognosy and Phytotherapy, Târgu. Mureş, Romania
2.Corvinus University of Budapest, Faculty of Food Science, Department of Microbiology and Biotechnology, Budapest, Hungary
3.University of Pécs, Faculty of Science, Department of Analytical and Environmental Chemistry, Pécs, Hungary
4.Semmelweis University, Faculty of Pharmacy, Institute of Pharmacognosy, Budapest, Hungary
5.University of Pécs, Medical School, Department of Pharmacognosy, Pécs, Hungary

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THE EFFECTS OF SOFT MATTER VESICLES ENTRAPPING MAGNESIUM CHLORIDE IN NOCICEPTIVE REACTIVITY IN MICE

MIHAELA BOANCA¹, LILIANA MITITELU-TARTAU¹, RAOUL VASILE LUPUSORU², VLADIMIR POROCH³, NELA BIBIRE^4*, CATALINA ELENA LUPUSORU¹

1.University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Pharmacology-Algesiology, Universitatii St. no. 16, code 700115, Iasi, Romania
2.University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Patho-Physiology, Universitatii St. no. 16, code 700115, Iasi, Romania
3.University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Surgery, Universitatii St. no. 16, code 700115, Iasi, Romania
4.University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Pharmacy, Department of Analytical Chemistry, Universitatii St. no. 16, code 700115, Iasi, Romania

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VALIDATION AND APPLICATION OF A NEW DAD-HPLC METHOD FOR DETERMINATION OF LORATADINE FROM PHARMACEUTICALS

GEORGETA PAVALACHE^1*, VASILE DORNEANU², ANTOANELA POPESCU¹

1.”Ovidius” University Constanta, Faculty of Pharmacy, Constanţa, Romania
2.”Gr. T. Popa” University, Faculty of Pharmacy, Iasi, Romania

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LOW DOSE TAMOXIFEN AS TREATMENT OF BENIGN BREAST PROLIFERATIVE LESIONS

CRISTIAN BĂLĂLĂU¹, ȘTEFAN VOICULESCU^2*, ION MOTOFEI¹, RĂZVAN VALENTIN SCĂUNAȘU², CAROLINA NEGREI³

1.Department of General Surgery, “Carol Davila” University of Medicineand Pharmacy, “St. Pantelimon” Emergency Universitary Hospital, 340-342, Pantelimon Main Road , Sector 2, Bucharest, Romania
2.Department of General Surgery, “Carol Davila” University of Medicineand Pharmacy, Colțea Universitary Hospital, 1, I.C. Bratianu Boulevard, Sector 3 Bucharest, Romania
3.Department of Toxicology, “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6, Traian Vuia Street, 020956, Bucharest, Romania

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ADVANCES IN RESEARCH OF NEW 2-((4-ETHYLPHENOXY)METHYL)- N-(ARYLCARBAMOTHIOYL)BENZAMIDES

CARMEN LIMBAN¹, ALEXANDRU VASILE MISSIR¹, DIANA CAMELIA NUŢĂ^1*, MIRON TEODOR CĂPROIU², LAURENȚIU MORUSCIAG¹, CORNEL CHIRIŢĂ¹, AILIN CUPII¹, HOREA GURGU¹

1.University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Bucharest, Romania, 6 Traian Vuia St., Bucharest, 020956, Romania
2.The Organic Chemistry Center of Romanian Academy “C. D. Neniţescu”, 202B Splaiul Independenţei, Bucharest, Romania

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SIMULTANEOUS QUANTIFICATION OF ATORVASTATIN AND AMLODIPINE IN POWDER BLENDS FOR TABLETING BY NIR SPECTROSCOPY AND CHEMOMETRY

ANDREEA LOREDANA VONICA-GLIGOR^1,2,3, TIBOR CASIAN¹, ANDRA REZNEK¹, IOAN TOMUȚĂ^1*, FELICIA GLIGOR²

1."Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, 400023, Romania
2.“Lucian Blaga” University, Lucian Blaga, 2A, Sibiu, 550169, Romania
3.S.C. Polipharma INDUSTRIES, Sibiu, 550052, Romania

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COUNSELING ON THE USE OF PERSONAL MEDICAL DEVICES AND DRUG-DELIVERY PRODUCTS – A TRADITIONAL OR EXTENDED COMMUNITY PHARMACY SERVICE?

TAGNE RATASSEPP¹, ALINA SHAGANDINA², JUHA TURUNEN³, RIITTA AHONEN⁴, PEEP VESKI², JYRKI HEINÄMÄKI², DAISY VOLMER^2*

1.Medical Device Department, Estonian Health Board, Põllu 1a, 50303 Tartu, Estonia
2.Department of Pharmacy, Faculty of Medicine, University of Tartu, 1 Nooruse Street, 50411 Tartu, Estonia
3.Farenta Oy, Äyritie 16, 01510 Vantaa, Finland
4.School of Pharmacy, Faculty of health Sciences, University of Eastern-Finland, P.O. Box 1627, 70211 Kuopio, Finland

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STATISTICAL REPORTING IN PHARMACEUTICAL PAPERS FROM ROMANIAN JOURNALS

DANIEL-CORNELIU LEUCUȚA¹, TUDOR DRUGAN^1*, ANDREEA FARCAŞ², ANDREI ACHIMAȘ¹

1.Department of Medical Informatics and Biostatistics, “Iuliu Haţieganu”, University of Medicine and Pharmacy Cluj- Napoca, 6 Louis Pasteur, 400349, Cluj-Napoca, Romania
2.Drug Information Research Centre Cluj-Napoca, “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Pasteur Street No. 6, 400349, Romania

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HOMEOSTATIC CHANGES DURING ANTICONVULSANT MEDICATION IN CHILDREN

MICHAELA DOBRE¹, COSTINELA GEORGESCU^2*, VICTORITA STEFANESCU³, MAGDALENA CUCIUREANU⁴, AUREL NECHITA⁵, MANUELA ARBUNE⁵

1.Department of Functional Sciences, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 35, Al. I Cuza Street, Galati, Romania
2.Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 35, Al. I Cuza Street, Galati, Romania
3.Department of Morphological Sciences, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 35, Al. I Cuza Street, Galati, Romania
4.Department of Pharmacology, Faculty of Medicine, "Gr. T. Popa" University of Medicine and Pharmacy, 16, Universitatii Street, Iasi, Romania
5.Clinical Department, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University of Galati, 35, Al. I Cuza Street, Galati, Romania

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ANTIBIOTHERAPY IN HOSPITAL – BETWEEN THE EFFICIENCY AND QUALITY OF MEDICAL SERVICES. THE ROLE OF THE DRUG COMMITTEE

LUCIA DAINA^1*, GHEORGHE CARP¹, CORINA NEAMȚU², ALINA VENTER¹, PETRU ARMEAN³

1.University of Oradea, Faculty of Medicine and Pharmacy, 10, 1 Decembrie Square, Oradea, Romania
2.Clinical County Emergency Hospital Oradea, 37, Republicii Street, Oradea, Romania
3.University of Medicine and Pharmacy “Carol Davila”, 6, Traian Vuia Street, Bucharest, Romania

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CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITY OF ESSENTIAL OIL FROM ROMANIAN SATUREJA MONTANA L.

ADRIANA TRIFAN¹, ANA CLARA APROTOSOAIE^1*, MIHAI BREBU², OANA CIOANCĂ¹, ELVIRA GILLE³, MONICA HĂNCIANU¹, ANCA MIRON¹

1.Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, 16 Universitatii Street, 700115, Iasi, Romania
2.Physical Chemistry of Polymers Laboratory, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 70048, Iasi, Romania
3.National Institute of R&D for Biological Sciences/“Stejarul” Biological Research Centre, 6 Alexandru cel Bun Street, 610004, Piatra Neamț, Romania

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CHEMOTHERAPY FOR BREAST CANCER DURING PREGNANCY AND POSTPARTUM: A RETROSPECTIVE DESCRIPTIVE STUDY

ANCA A. SIMIONESCU^1,2*, DRAGOȘ MEDIAN³

1.“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2.Filantropia Clinical Hospital, Department of Obstetrics and Gynecology, Department of Fetal Maternal Medicine, 11-13, Ion Mihalache Boulevard, Bucharest, Romania
3.Filantropia Clinical Hospital, Department of Gynaecological Oncology, 11-13, Ion Mihalache Boulevard, Bucharest, Romania

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POSSIBLE SUBSTITUTES FOR PARACETAMOL: THE RESULTS OF A COMPREHENSIVE SCREENING BASED ON STRUCTURAL SIMILARITY AND DOCKING SIMULATION ON THE SURFACE OF ENZYMES

LÁSZLÓ FERENCZ^1*, DANIELA LUCIA MUNTEAN²

1.Sapientia Hungarian University of Transylvania, Faculty of Technical and Human Sciences, Str. Sighişoarei 1C, Tîrgu- Mureş – Corunca, 540485, Romania
2.University of Medicine and Pharmacy Tîrgu-Mureș, Faculty of Pharmacy, Str. Gh. Marinescu, 38, Tîrgu-Mureș, 540139, Romania

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THROMBOPROPHYLAXIS USING LOW MOLECULAR WEIGHT HEPARINE AFTER ANKLE FRACTURES

GHEORGHE ION POPESCU ^1,2#*, OLIVERA LUPESCU ^1,2#*, CRISTINA PATRU ^2#, ELENA LUMINITA STANCIULESCU ^2#, MIHAIL NAGEA², ALEXANDRU DIMITRIU², IOANA CRISTINA GRINTESCU², DORIANA LUPESCU³

1.University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu, 020022 Bucharest, Romania
2.Clinical Emergency Hospital Bucharest, 8 Calea Floreasca, 014461 Bucharest, Romania
3.Anesthesia and Intensive Care Unit, Buftea Hospital “Maria Burghele”, 5 Studioului, 70000 Ilfov, Romania

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ENHANCEMENT OF DISSOLUTION RATE OF FENOFIBRATE BY SPRAY DRYING TECHNIQUE: COMPARISON OF EUDRAGIT E-100, SOLUTOL® HS15 AND HYDROXYPROPYL CELLULOSE AS CARRIERS

JALEH VARSHOSAZ^*, ERFANEH GHASSAMI

Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran

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CLINICAL AND THERAPEUTICAL ASPECTS OF BIPOLAR DISORDER: THE SWITCH ON DEPAKINE CHRONO® FROM OTHER VALPROATE TREATMENTS – RETROSPECTIVE DATA COLLECTION

MARIA LADEA^1*, MIHAELA CRISTINA ŞINCA², CRISTINA MARIA BARBU³, MIHAI BRAN⁴

1.University of Medicine and Pharmacy “Carol Davila”, Clinical Hospital of Psychiatry “Alexandru Obregia”, Bucharest, Romania
2.Balneomedcenter Hospital, Ramnicu-Valcea, Romania
3.Amiris Clinic, Bucharest, Romania
4.Coltea Hospital, Bucharest, Romania

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ASSESSMENT OF FLUVOXAMINE EFFECTS ON THE PHARMACOKINETICS OF ZOLPIDEM AND ITS METABOLITE IN HEALTHY VOLUNTEERS

ANA-MARIA GHELDIU¹, ADINA POPA², MARIA NEAG³, DANA MUNTEAN¹, CORINA BOCSAN³, ANCA BUZOIANU³, LAURIAN VLASE^1*, MARCELA ACHIM¹, IOANA TODOR¹, CORINA BRICIU²

1.University of Medicine and Pharmacy “Iuliu Hatieganu”, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Victor Babes 41, RO-400012, Cluj-Napoca, Romania
2.University of Medicine and Pharmacy “Iuliu Hatieganu”, Faculty of Pharmacy, Department of Clinical Pharmacy, Ion Creanga 12, RO-400010, Cluj-Napoca, Romania
3.University of Medicine and Pharmacy, "Iuliu Hatieganu”, Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Gheorghe Marinescu 23, RO-400337, Cluj-Napoca, Romania

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EVALUATION OF ANTINOCICEPTIVE ACTION OF BINARY COMBINATIONS OF SODIUM VALPROATE AND ANALGESIC DRUGS

LIDIA CRISTINA CHIŢAC¹, ILEANA COJOCARU^2*, S. BEŞCHEA³, MONICA NEAMŢU¹, DELIA BULEA¹, VERONICA BILD¹

1.Department of Pharmacodynamics and Clinical Pharmacy, University of Medicine and Pharmacy, “Grigore. T. Popa” Iaşi
2.Department of Pharmaceutical Technology, University of Medicine and Pharmacy, “Grigore. T. Popa” Iaşi
3.Department of Toxicology, Faculty of Veterinary Medicine, USAMV Iaşi

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HAEMATOLOGICAL ADVERSE EFFECTS OF INTERFERON AND RIBAVIRIN TREATMENT IN PATIENTS WITH CHRONIC C VIRUS HEPATITIS

CITTO IULIAN TAISESCU^1#*, GABRIELA ILIESCU^2#, OANA TAISESCU^3#, ANCA PREDESCU^4#, ANA MARINA ANDREI^5#, BOGDAN CĂTĂLIN^1#, CRISTIAN SILOȘI^6#, VIOREL BICIUȘCĂ^7#

1.Department of Physiology, University of Medicine and Pharmacy, 2 Petru Rareș, 200349, Craiova, Romania
2.Clinical Laboratory, County Clinical Emergency Hospital Craiova, 1 Tabaci, 200642, Craiova, Romania
3.Department of Anatomy, University of Medicine and Pharmacy, 2 Petru Rareș, 200349, Craiova, Romania
4.Clinical Laboratory, Clinical Hospital of Neuropsychiatry Craiova, 99 Calea Bucureşti, 200473, Craiova, Romania
5.Department of Semiology, University of Medicine and Pharmacy, 2 Petru Rareș, 200349, Craiova, Romania
6.Department of Surgery, University of Medicine and Pharmacy, 2 Petru Rareș, 200349, Craiova, Romania
7.Department of Semiology, University of Medicine and Pharmacy, 2 Petru Rareș, 200349, Craiova, Romania

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RESULTS IN THE TREATMENT OF CHILDREN’S FACE AND NECK HEMANGIOMAS AND VASCULAR MALFORMATIONS – WITH INTRALESIONAL OR PERILESIONAL BLEOMYCIN INJECTION

SEBASTIAN IONESCU^1#*, BOGDAN ANDREI^1#, MIHAI MOCANU^1#, ELENA LICSANDRU^1#, IONUT SECHELI^1#, MARIAN SECHELI^1#, MIRELA VASILESCU^2#

1.“Marie S. Curie” Emergency Children Hospital - Department of Paediatric Surgery, 20, Bd. C-tin Brancoveanu, sector 4, Bucharest, 041451, Romania.
2.“Univerity of Craiova” – Department of Kinesiology and Sports Medicine, 20, Bd. C-tin Brancoveanu, sector 4, Bucharest, 041451, Romania.

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