Romanian Society of Pharmaceutical Sciences
 

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THE EFFECTS OF SOFT MATTER VESICLES ENTRAPPING MAGNESIUM CHLORIDE IN NOCICEPTIVE REACTIVITY IN MICE

MIHAELA BOANCA1, LILIANA MITITELU-TARTAU1, RAOUL VASILE LUPUSORU2, VLADIMIR POROCH3, NELA BIBIRE4*, CATALINA ELENA LUPUSORU1

1.University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Pharmacology-Algesiology, Universitatii St. no. 16, code 700115, Iasi, Romania
2 .University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Patho-Physiology, Universitatii St. no. 16, code 700115, Iasi, Romania
3 .University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Surgery, Universitatii St. no. 16, code 700115, Iasi, Romania
4 .University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Pharmacy, Department of Analytical Chemistry, Universitatii St. no. 16, code 700115, Iasi, Romania

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The study investigates the effects of magnesium nanovesicles on cutaneous nociception assessed using tail immersion test in mice. Nanoparticles were prepared by magnesium chloride immobilization inside lipid vesicles followed by stabilization with chitosan. The experiment was carried out on white Swiss mice, divided into 3 groups of 7 animals each, treated orally 7 consecutive days. In tail immersion test, the latency time response was recorded 15, 30, 60, 90 minutes, 2, 4, 6, 8, 10 and 12 hours after substances administration. We developed new carrier formulations that entrapped magnesium chloride in lipid vesicles with high efficacy and we proved that high stability magnesium nanovesicles can be designed. The administration of magnesium nanovesicles displayed a prolonged antinociceptive effect compared with the non-entrapped substance in tail immersion test.