Romanian Society of Pharmaceutical Sciences
 

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RESULTS IN THE TREATMENT OF CHILDREN’S FACE AND NECK HEMANGIOMAS AND VASCULAR MALFORMATIONS – WITH INTRALESIONAL OR PERILESIONAL BLEOMYCIN INJECTION

SEBASTIAN IONESCU1#*, BOGDAN ANDREI1#, MIHAI MOCANU1#, ELENA LICSANDRU1#, IONUT SECHELI1#, MARIAN SECHELI1#, MIRELA VASILESCU2#

1.“Marie S. Curie” Emergency Children Hospital - Department of Paediatric Surgery, 20, Bd. C-tin Brancoveanu, sector 4, Bucharest, 041451, Romania.
2.“Univerity of Craiova” – Department of Kinesiology and Sports Medicine, 20, Bd. C-tin Brancoveanu, sector 4, Bucharest, 041451, Romania.

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Bleomycin, a polypeptidic antineoplasic antibiotic, was introduced in the treatment of vascular anomalies as sclerosant agent if injected intralesionally or perilesionally. The study was performed between 2008-2012 on a group of 44 children with various vascular anomalies of the face and neck, age ranging from 21 days to 15 years old, who were subjected to local bleomycin injection. For an accurate pursuance and estimation of the efficacy of the treatment, we used the classification of vascular anomalies suggested by Mulliken and Glowacki in 1982 which allowed us a quick diagnosis. Excellent results allowed the usage of bleomycin on a large scale in the local treatment of vascular anomalies located on the child’s face and neck. There were no major side effects or complications by intralesional or perilesional bleomycin administration.