Romanian Society of Pharmaceutical Sciences
 

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EVALUATION OF ANTINOCICEPTIVE ACTION OF BINARY COMBINATIONS OF SODIUM VALPROATE AND ANALGESIC DRUGS

LIDIA CRISTINA CHIŢAC1, ILEANA COJOCARU2*, S. BEŞCHEA3, MONICA NEAMŢU1, DELIA BULEA1, VERONICA BILD1

1.Department of Pharmacodynamics and Clinical Pharmacy, University of Medicine and Pharmacy, “Grigore. T. Popa” Iaşi
2.Department of Pharmaceutical Technology, University of Medicine and Pharmacy, “Grigore. T. Popa” Iaşi
3.Department of Toxicology, Faculty of Veterinary Medicine, USAMV Iaşi

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In the recent years, substances without a basic analgesic action were used for the treatment of different types of pain, which do not have a basic analgesic action. Recently, valproic acid was used in combination with some analgesics in the treatment of various types of pain. This study aimed to identify the type of pharmacodynamic interaction of valproic acid with analgesics. The study was conducted on mice, using an inflammatory pain model. The results demonstrate the synergism between valproic acid and tramadol, the subadditivity between valproic acid and paracetamol. These results may lead to useful hypotheses concerning the action mechanisms of these substances and to the development of binary combinations in fixed proportion that might represent more effective modalities of treating pain.