Farmacia Journal 1/2020
Volume 68 | Number 1 | Year 2020
Download this issue’s covers and announcements.
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NEW INSIGHTS INTO BROWN ADIPOSE TISSUE AS A PHARMACOLOGICAL TARGET IN OBESITY
ANA MARINA ANDREI 1#, ANCA BERBECARU-IOVAN 1#, FELIX RAREŞ IOAN DIN-ANGHEL 2, IOANA DANIELA BINIŞOR 2,3, ROXANA MARIA MARINESCU 2, LILIANA DALIA GOGA 2, ILEANA MONICA BANIȚĂ 4*, CĂTĂLINA GABRIELA PISOSCHI 1
1.2nd Department of Pharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania
2.PhD Student, IOSUD University of Medicine and Pharmacy of Craiova, Romania
3.Binisan Medical Center, Dragasani, Romania
4.Department of Morphological Sciences, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania -
BIOEVALUATION OF THE ANTIMICROBIAL AND ANTI-PROLIFERATIVE POTENTIAL OF SOME DERIVATIVES OF 3,5-DINITRO-4-METHOXYAMINO-BENZOIC ACID
IRINA ZARAFU 1, BIANCA PĂTRAȘCU 1, LUMINIȚA MĂRUȚESCU 2, CORALIA BLEOTU 3, CARMEN LIMBAN 4, ARNAUD TATIBOUËT 5, MARIANA CARMEN CHIFIRIUC 2*, DIANA CAMELIA NUȚĂ 4, PETRE IONIȚĂ 1
1.University of Bucharest, Faculty of Chemistry, Organic Chemistry, Biochemistry and Catalysis Department, 90-92 Panduri Road, Bucharest, Romania
2.University of Bucharest, Faculty of Biology and the Research Institute of the University of Bucharest, 91-95 Splaiul Independenței Street, Bucharest, Romania
3.“Ștefan S. Nicolau” Institute of Virology, Cellular and Molecular Pathology Department, 285 Mihai Bravu Road, 030304, Bucharest, Romania
4.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Pharmaceutical Chemistry Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
5.University of Orleans, ICOA-UMR7311, CNRS, France -
PHENOLIC CONTENT AND ANTIOXIDANT CAPACITY OF POMACE AND CANES EXTRACTS OF SOME VITIS VINIFERA VARIETIES CULTIVATED IN ROMANIA
MIRELA L. MOLDOVAN 1, CĂTĂLINA BOGDAN 1*, SONIA IURIAN 1, CECILIA ROMAN 2, ILIOARA ONIGA 1, DANIELA BENEDEC 1
1.“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania
2.National Institute for Research-Development for Optoelectronics INOE 2000, Cluj-Napoca Branch, Romania -
ANTIFUNGAL POTENTIAL OF PIMPINELLA ANISUM, CARUM CARVI AND CORIANDRUM SATIVUM EXTRACTS. A COMPARATIVE STUDY WITH FOCUS ON THE PHENOLIC COMPOSITION
ADRIANA TRIFAN 1, ANDRA-CRISTINA BOSTĂNARU 2*, SIMON VLAD LUCA 1,3, ADINA CATINCA GRĂDINARU 1, ALEXANDRA JITĂREANU 1, ANA CLARA APROTOSOAIE 1, ANCA MIRON 1, OANA CIOANCĂ 1, MONICA HĂNCIANU 1, LĂCRĂMIOARA OCHIUZ 1, ALEXANDRA BUJOR 1, PETRUȚA AELENEI 4, MIHAI MAREȘ 2
1.Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy Iaşi, 16 Universităţii Street, 700115, Iaşi, Romania
2.Laboratory of Antimicrobial Chemotherapy, Ion Ionescu de la Brad University of Agricultural Sciences and Veterinary Medicine of Iasi, 8 Aleea Mihail Sadoveanu, 700489, Iaşi, Romania
3,Biothermodynamics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Maximus-von-Imhof-Forum 2, 85354, Freising, Germany
4.Fiterman Pharma LLC, 127 Păcurari Street, 700544, Iaşi, Romania -
CERAMIDE AND SPHINGOMYELIN LEVELS IN THE RAT BRAIN AFTER CHRYSIN INTAKE
HALINA CAR 1,4#, ANNA FIEDOROWICZ 1,2#, MAŁGORZATA ŻENDZIAN-PIOTROWSKA 3, ADRIAN CHABOWSKI 4, SYLWIA K. NALIWAJKO 5, KATARZYNA SOCHA 5, RENATA MARKIEWICZ-ŻUKOWSKA 5, WIOLETA J. OMELJANIUK 5, MARIA H. BORAWSKA 5*
1.Department of Experimental Pharmacology, Medical University of Bialystok, Poland
2.Laboratory of Tumor Molecular Immunobiology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
3.Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, Poland
4.Department of Physiology, Medical University of Bialystok, Poland
5.Department of Bromatology, Medical University of Bialystok, Poland -
CLINICAL FACTORS INFLUENCING ANTIPSYCHOTIC CHOICE, DOSE AND AUGMENTATION IN PATIENTS TREATED WITH LONG ACTING ANTIPSYCHOTICS
LIANA DEHELEAN 1#, ANA MARIA ROMOŞAN 1*, MINODORA ANDOR 2#, VALENTINA OANA BUDA 3#, ANA CRISTINA BREDICEAN 1#, MINODORA MARINELA MANEA 4, ION PAPAVĂ 1, RADU ŞTEFAN ROMOŞAN 1
1.Department of Psychiatry, “Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square, Timişoara, Romania
2.Department of Medical Semiology II, “Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square, Timişoara, Romania
3.Department of Pharmacology and Clinical Pharmacology, “Victor Babeş” University of Medicine and Pharmacy, 2 E. Murgu Square, Timişoara, Romania
4.Department of Psychology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8 V. Babeş Street, Cluj-Napoca, Romania -
LIVER FUNCTION IN A COHORT OF YOUNG HIV-HBV CO-INFECTED PATIENTS ON LONG-TERM COMBINED ANTIRETROVIRAL THERAPY
ADELINA ROȘCA 1,2#, DIANA IACOB 3#, LUMINIȚA ENE 4, AURA TEMEREANCA 1,2, CAMELIA GRANCEA 2, CAMELIA SULTANA 1,2, CRISTIAN L. ACHIM 5, SIMONA RUȚĂ 1,2*
1.Virology Department, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474, Bucharest, Romania
2.Viral Emerging Diseases Department, “Ștefan S. Nicolau” Institute of Virology, 285 Mihai Bravu Road, 030304, Bucharest, Romania
3.Infectious Diseases Department, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474, Bucharest, Romania
4.HIV/AIDS Department, “Dr Victor Babeș” Clinical Hospital of Infectious and Tropical Diseases, 281 Mihai Bravu Road, 030303, Bucharest, Romania
5.Pathology Department, University of California at San Diego, 9500 Gilman, La Jolla, CA 92093, USA -
IN SILICO STUDIES ON SOME DENGUE VIRAL PROTEINS WITH SELECTED ALLIUM CEPA OIL CONSTITUENTS FROM ROMANIAN SOURCE
GABRIELA TATARINGA 1*, ADRIAN SPAC 1, BALASUBRAMANIAN SATHYAMURTHY 2, ANA MARIA ZBANCIOC 1
1.University of Medicine and Pharmacy “Grigore T. Popa” Iași, Romania
2.Ramaiah College of Arts, Science and Commerce, Bangalore, Karnataka, India -
QUANTITATIVE STRUCTURE-HEPATOTOXICITY ASSESSMENT OF SERIES ARYLPIPERAZINE-N1-SUBSTITUTED THEOBROMINE DERIVATIVES
MAGDALENA KONDEVA-BURDINA 1, IVA VALKOVA 2, LILY ANDONOVA 3, MAYA GEORGIEVA 3*, VIRGINIA TZANKOVA 1, ALEXANDER ZLATKOV 3
1.Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University-Sofia, 2 “Dunav” str., 1000, Sofia, Bulgaria
2.Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 “Dunav” str., 1000, Sofia, Bulgaria
3.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 “Dunav” str., 1000, Sofia, Bulgaria -
INTERFERON-β 1A, AN IMMUNOMODULATOR IN RELAPSING REMITTING MULTIPLE SCLEROSIS PATIENTS. THE EFFECT ON PRO-INFLAMMATORY CYTOKINES
SMARANDA MAIER 1, ANCA MOTATAIANU 1*, LAURA BARCUTEAN 1, ALINA BALINT 2, ADINA HUTANU 3, BAJKO ZOLTAN 1, ADINA STOIAN 4, ANDREEA ROMANIUC 5, SEBASTIAN ANDONE 5, RODICA BALASA 1
1.Neurology Department, Faculty of Medicine, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” Târgu Mureș, Romania
2.Department of Analitycal Chemistry and Drug Analysis, Faculty of Pharmacy, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” Târgu Mureș, Romania
3.Laboratory Medicine Department, Faculty of Medicine, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” Târgu Mureș, Romania
4.Pathophysiology Department, Faculty of Medicine, University of Medicine, Pharmacy, Sciences and “George Emil Palade” Târgu Mureș, Romania
5.Doctoral School (I.O.S.U.D.) of the “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania. -
RELATIVE BIOAVAILABILITY OF TWO FORMULATIONS CONTAINING DAPAGLIFLOZIN 10 MG UNDER FED CONDITION IN A RANDOMIZED CROSSOVER STUDY IN HEALTHY CAUCASIAN SUBJECTS
MONICA OROIAN 1,2, DIANA IOANA POP 1,2, ANA-MARIA GHELDIU 3*, SANDEEP BHARDWAJ 2, ADRIANA MARCOVICI 2, ARSHAD KHUROO 4, LAURIAN VLASE 1
1.Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania
2.Clinical Pharmacology and Pharmacokinetics Department, Terapia SA – a Sun Pharma Company, Cluj-Napoca, Romania
3.Department of Pharmaceutical Botany, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Romania
4.Clinical Pharmacology and Pharmacokinetics Department, Gurugram, India -
EVALUATION OF OXIDATIVE STRESS IN SMOKING AND NON-SMOKING PATIENTS DIAGNOSED WITH ANXIOUS-DEPRESSIVE DISORDER
LETITIA TROFOR 1#, RADU CRISAN-DABIJA 1*, MONA ELISABETA CIOROIU 2#, MILENA ADINA MAN 3, IONEL BOGDAN CIOROIU 4, IOANA BUCULEI 1, RADU-IONEL CERNAT 1, CRISTINEL STEFANESCU 1, ANTIGONA CARMEN TROFOR 1
1.University of Medicine and Pharmacy ”Grigore. T. Popa”, Iași, Romania
2.Department of Clinical Biochemistry, Clinical Hospital of Pulmonary Disease, Iași, Romania
3.University of Medicine and Pharmacy ”Iuliu Hațieganu” Cluj-Napoca, Romania
4.Romanian Academy, Iași Branch, Research Center for Oenology, Iași, Romania -
RETROSPECTIVE STUDY ON ANGIOTENSIN-CONVERTING-ENZYME INHIBITORS TREATMENT
FLORIN MAGHIAR 1, LAURA GRAȚIELA VICAȘ 2*, ANDREEA ARDELEAN 3, ALIN TEUȘDEA 4, OTILIA ANCA ȚICA 1, CLAUDIU OROS 2, MARIANA EUGENIA MUREȘAN 5
1.University of Oradea, Faculty of Medicine and Pharmacy, Medical Department, Oradea, Romania
2.University of Oradea, Faculty of Medicine and Pharmacy, Pharmacy Department, Oradea, Romania
3.“Dr. G. Curteanu” Municipal Clinical Hospital, Oradea, Romania
4.University of Oradea, Faculty of Environmental Protection, Oradea, Romania
5.University of Oradea, Faculty of Medicine and Pharmacy, Preclinical Disciplines Department, Oradea, Romania -
OPTIMIZATION OF THE COLLOIDAL PROPERTIES OF DIFFERENT VESICULAR SYSTEMS AIMING TO ENCAPSULATE (-)-EPIGALLOCATECHIN-3-GALLATE
MAHA EL KAYAL 1, MAHA NASR 2*, NAHED MORTADA 2, SEHAM ELKHESHEN 1
1.Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt
2.Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Egypt -
EVALUATION OF MICONAZOLE NITRATE PERMEABILITY THROUGH BIOLOGICAL MEMBRANE FROM DERMAL SYSTEMS
MAGDALENA BÎRSAN 1,3, ANA CATERINA CRISTOFOR 2, PAULA ANTONOAEA 3, NICOLETA TODORAN 3*, NELA BIBIRE 4, ALINA DIANA PANAINTE 4, ROBERT ALEXANDRU VLAD 3, MIHAELA GRIGORE 5, ADRIANA CIURBA 3
1.“Grigore T. Popa” University of Medicine and Pharmacy of Iași, Departament of Pharmaceutical Sciences II, 16 Universității Street, Iași, Romania
2.“Grigore T. Popa” University of Medicine and Pharmacy of Iași, Medical Department III, 16 Universității Street, Iași, Romania
3.University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, Department of Pharmaceutical Technology and Cosmetology, 38 Gh. Marinescu Street, Târgu Mureș, Romania
4.“Grigore T. Popa” University of Medicine and Pharmacy of Iași, Departament of Pharmaceutical Sciences I, 16 Universității Street, Iași, Romania
5.“Grigore T. Popa” University of Medicine and Pharmacy of Iași, Department of Obstetrics and Gynaecology, 16 Universității Street, Iasi, Romania -
FREE RADICAL SCAVENGING ACTIVITY AND TOTAL POLYPHENOL CONTENT OF SECURIDACA LONGIPEDUNCULATA ROOTS AND LEAVES EXTRACTS
TITUS CHUKWUEMEKA OBASI 1#, DANIELA BENEDEC 2#, DANIELA HANGANU 2, ANA-MARIA GHELDIU 3, LAURIAN VLASE 3, ILIOARA ONIGA 2*, CRISTINA PUȘCAȘ 4, RADU SILAGHI-DUMITRESCU 4#, RADU OPREAN 1
1.Department of Analytical Chemistry and Instrumental Analysis, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2.Department of Pharmacognosy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
3.Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
4.Department of Chemistry and Chemical Engineering, “Babeş-Bolyai” University, Cluj-Napoca, Romania -
THE PROTECTIVE EFFECT OF ULINASTATIN IN SEVERE SEPSIS. A MECHANISTIC APPROACH
SANJUN ZHOU 1, HONG GAO 2, JING CHEN 2, WENBING LIU 2*
1.Department of ICU, The Affiliated Hospital of HangZhou Normal University, HangZhou 310015, Zhejiang, China
2.Department of Rehabilitation, The Third Affiliated Hospital of Zhejiang Chinese Medical University, HangZhou 310015, Zhejiang, China -
THE PREVALENCE AND SPECTRUM OF MYCOBACTERIUM TUBERCULOSIS CHEMORESISTANCE AMONG TB PATIENTS
ARIADNA PETRONELA FILDAN 1#, IOAN ANTON ARGHIR 2#, GEORGETA GILDA POPESCU 3*, CLARA MATEI 4, ROXANA MARIA NEMES 3, DOINA TOFOLEAN 1#, ELENA DANTES 1, CORINA SILVIA POP 5, SIMONA CLAUDIA CAMBREA 1
1.Faculty of Medicine, “Ovidius” University of Constanța, 124 Mamaia Boulevard, 900527, Constanța, Romania
2.Pulmonology Department, “Sf. Andrei” Clinical Emergency Hospital, 145 Tomis Boulevard, 900591, Constanța, Romania
3.Pulmonology Department, “Marius Nasta” Hospital, 90 Viilor Road, 050152, Bucharest, Romania
4.Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
5.Department of Internal Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania -
THE EVALUATION OF NORMO-GLYCEMIC AND CYTO-REGENERATIVE EFFECTS OF PELARGONIUM SPECIES EXTRACTS
CRISTINA IANCU 1#, CORNELIA MIRCEA 1#, FLORIN PETRARIU 2*, OANA CIOANCĂ 3, CĂTĂLINA STAN 4, ANDREIA CORCIOVĂ 5, ANDREEA MURĂRAȘU 1, NINA FILIP 6, MONICA HĂNCIANU 3
“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iași, Romania
1.Department of Pharmaceutical Biochemistry and Clinical Laboratory
2.Department of Hygiene and Environmental Health
3.Department of Pharmacognosy
4.Department of Pharmaceutical Industry and Biotechnologies
5.Department of Drug Analysis
6.Department of Biochemistry -
STANDARDIZATION OF A METHOD FOR FREEZE-DRYING OF ANTIBODIES AS READY TO USE THERAPEUTIC RADIOPHARMACEUTICALS
WANJEH DAVID MWANZA 1, ASCHALEW ALEMU MARIE 1, MARIJA STERJOVA 1, ZORICA ARSOVA-SARAFINOVSKA 1,2, PAULINA EFREMOVA 1, EMILIJA JANEVIK-IVANOVSKA 1,3*
1.Faculty of Medical Sciences, Goce Delcev University, Krste Misirkov 10-A, 2000 Stip, Republic of Macedonia
2.Institute of Public Health, 50 Divizija 6, 1000 Skopje, Republic of Macedonia
3.University Institute for Positron-Emission Tomography, Bledski Dogovor 10, 1000 Skopje, Republic of Macedonia -
VITAMIN D FROM FOOD AND SUPPLEMENT INTAKE IN PREGNANCY. A PILOT STUDY
CORINA ZUGRAVU 1,2#, AGRIPINA RAȘCU 1#, MARINA RUXANDRA OȚELEA 1*, ADRIANA MACRI 3
1.“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
2.National Institute of Public Health, Bucharest, Romania
3.National Institute of Research and Development for Food Bioresources, Bucharest, Romania -
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF BENZOXAZOLE DERIVATIVES WITH THEIR SAR ANALYSIS BY SAS-MAP
KAMIAR ZOMORODIAN 1, SOGHRA KHABNADIDEH 2, AMIRHOSSEIN SAKHTEMAN 2, BI BI FATEMEH MIRJALILI 3, MOHSEN RANJBAR 2, LEILA ZAMANI 2*
1.Department of Parasitology & Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
2.Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
3.Department of Chemistry, College of Science, Yazd University, Yazd, P. O. Box 8915813149, Iran -
CLINICAL STUDIES ON THE RELATIONSHIP OF THE SHORT DURATION OF USE OF MIDAZOLAM WITH THE OCCURRENCE OF DELIRIUM IN ICU PATIENTS WITH MECHANICAL VENTILATION
ZHI-FENG CHEN
Department of Critical Care Medicine, Changde First People's Hospital 415000, Hunan Province, China
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A NOVEL METHOD FOR THE EXTRACTION OF THE MAIN COMPOUNDS FROM THE ESSENTIAL OIL OF CLOVE BUDS
NIKOLAY N. BOYKO 1a,b*, ELENA T. ZHILYAKOVA 1b, DMITRIY I PISAREV 2, OLEG O. NOVIKOV 2, RITA V. SAHAIDAK-NIKITIUK 3a, VICTORIA YU. KUZNIETSOVA 3b, OLEG S. SHPYCHAK 3c, ALEKSANDR V. TKACHEV 4a, ANATOLIY M. KOVALENKO 4b, NATALIA A. SUSHCHUK 5
1.Laboratory of Technology of Drugsa, Department of Pharmaceutical Technologyb, Department of General Chemistryc, Belgorod National Research University, 85 Pobedy Street, Belgorod, Russia
2.Shared Knowledge Center (Research and Educational Center) “Drugs’ quality control center” Рeoples’ Friendship University of Russia, 8/2 Miklukho-Maklay Street, Moscow, Russia
3.Department of Processes and Apparatuses of Chemical and Pharmaceutical Industriesa, Department of Chemistry of Natural Compoundsb, Department of Industrial Pharmacy and Economy Institute for Advanced Training of Pharmacy Specialistsc of National University of Pharmacy, 53 Pushkinska Street, Kharkiv, Ukraine
4.Department of General and Private Zootechnicsa, Department of Infectious and Invasive Pathologyb, Belgorod State Agricultural University named after V. Gorin, Federal State Budgetary Educational Institution of Higher Education, 3 Vavilova Street, Belgorod, Russia
5.Department of Technology of Drugs, Odessa National Medical University, 2 Valikhovsky Lane, Odessa, Ukraine -
INTERNSHIPS IN PHARMACEUTICAL STUDENTS’ DEVELOPMENT
DRAGOȘ FLORIAN CIOLAN 1, CĂTĂLINA LILIANA ANDREI 2*, ANDREEA MIRICĂ 3, IULIA ELENA TOMA 3, DOINA DRĂGĂNESCU 4, FLAVIAN ȘTEFAN RĂDULESCU 1
1.“Carol Davila” University of Medicine and Pharmacy, Centre for Drug Sciences (CedS), Bucharest, Romania
2.“Carol Davila” University of Medicine and Pharmacy, Department of Cardiology and Thoracic Pathology, Bucharest, Romania
3.Bucharest University of Economic Studies, Faculty of Economic Cybernetics, Statistics and Informatics, Statistics and Econometrics Department, Bucharest, Romania
4.“Carol Davila” University of Medicine and Pharmacy, Department of Pharmaceutical Physics and Informatics, Bucharest, Romania