Romanian Society of Pharmaceutical Sciences
 

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LIVER FUNCTION IN A COHORT OF YOUNG HIV-HBV CO-INFECTED PATIENTS ON LONG-TERM COMBINED ANTIRETROVIRAL THERAPY

ADELINA ROȘCA 1,2#, DIANA IACOB 3#, LUMINIȚA ENE 4, AURA TEMEREANCA 1,2, CAMELIA GRANCEA 2, CAMELIA SULTANA 1,2, CRISTIAN L. ACHIM 5, SIMONA RUȚĂ 1,2*

1.Virology Department, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474, Bucharest, Romania
2 .Viral Emerging Diseases Department, “Ștefan S. Nicolau” Institute of Virology, 285 Mihai Bravu Road, 030304, Bucharest, Romania
3 .Infectious Diseases Department, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474, Bucharest, Romania
4 .HIV/AIDS Department, “Dr Victor Babeș” Clinical Hospital of Infectious and Tropical Diseases, 281 Mihai Bravu Road, 030303, Bucharest, Romania
5 .Pathology Department, University of California at San Diego, 9500 Gilman, La Jolla, CA 92093, USA

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HIV-HBV co-infection was previously studied in patients older than 40 years of age, with added risk factors for liver disease. Data on progression of liver damage in young, co-infected patients, without associated comorbidities is sparse. We assessed the prevalence and stage of HBV co-infection in young individuals with parenterally acquired HIV infection and multiple previous antiretroviral (ART) treatments. Out of 227 patients (median age: 24 years, median duration of HIV infection: 23.9 years, median ART duration: 11.6 years), 61.7% had any markers of HBV infection, 53.6% were chronic HBsAg carriers, 9.3% had HBeAg present, 11.4% had high-levels of HBV DNA and 1.4% had severe liver fibrosis according to FIB-4 noninvasive score. HBV co-infected patients had longer ART exposure (147.07 vs. 121.3 months, p = 0.003) than those with HIVin the absence of HBV, with no significant differences in the use or duration of HIV-HBV dually-active antiretrovirals (lamivudine, tenofovir). Young HIV-HBV co-infected patients remain free of hepatic disease under ART.