THE EVALUATION OF NORMO-GLYCEMIC AND CYTO-REGENERATIVE EFFECTS OF PELARGONIUM SPECIES EXTRACTS
CRISTINA IANCU 1#, CORNELIA MIRCEA 1#, FLORIN PETRARIU 2*, OANA CIOANCĂ 3, CĂTĂLINA STAN 4, ANDREIA CORCIOVĂ 5, ANDREEA MURĂRAȘU 1, NINA FILIP 6, MONICA HĂNCIANU 3
“Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității Street, 700115, Iași, Romania
1.Department of Pharmaceutical Biochemistry and Clinical Laboratory
2.Department of Hygiene and Environmental Health
3.Department of Pharmacognosy
4.Department of Pharmaceutical Industry and Biotechnologies
5.Department of Drug Analysis
6.Department of Biochemistry
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Alpha-amylase and alpha-glucosidase are enzymes that modulate the chain breaking process of alpha-linked polysaccharides with an impact on promoting postprandial hyperglycaemia. Pancreatic alpha-amylase is an enzyme that catalyses the hydrolysis of starch and glycogen, yielding glucose and maltose. Alpha-glucosidase is an enzyme located in the brush border of the small intestine that acts upon alpha (1 → 4) glycosidic bonds. Alpha-glucosidase catalyses the hydrolysis of starch and disaccharides to glucose. The inhibition of these two enzymes is an important step in the management of postprandial hyperglycaemia. This research includes data about the anti-inflammatory effect and the rebounding capacity of cells in the presence of two extracts obtained from Pelargonium species. The results showed that the hydroalcoholic extract of P. grandiflorum had an inhibitory capacity of 55.67 0.06% at 0.625 mg/mL for alpha-amylase activity and 66.6 0.31% at 0.078 mg/mL for alpha-glucosidase activity. On the other hand, P. grandiflorum extract showed an improvement in the inflammatory process by about 50% and P. hispidum methanolic extract showed an anti-oedematous effect of 45% compared to the control.
