Romanian Society of Pharmaceutical Sciences

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THE INFLUENCE OF PERINDOPRIL ON PTX3 PLASMA LEVELS IN HYPERTENSIVE PATIENTS WITH ENDOTHELIAL DYSFUNCTION

VALENTINA BUDA 1#*, MINODORA ANDOR 2#, CARMEN CRISTESCU1, MIRELA VOICU1, LIANA SUCIU1, CALIN MUNTEAN3, OCTAVIAN CRETU4, DANA EMILIA BÂIBÂȚĂ5, CRISTINA MONICA GHEORGHIU6, MIRELA CLEOPATRA TOMESCU2

1.“Victor Babes" University of Medicine and Pharmacy Timișoara, Faculty of Pharmacy, Department of Pharmacology and Clinical Pharmacy, 2 Eftimie Murgu Street, 300041, Timișoara, Romania
2.”Victor Babes" University of Medicine and Pharmacy Timișoara, Faculty of Medicine, Department of Medical Semiotics, 2 Eftimie Murgu Street, 300041, Timișoara, Romania
3.”Victor Babes" University of Medicine and Pharmacy Timișoara, Faculty of Medicine, Department of Biostatistics and Medical Informatics, 2 Eftimie Murgu Street, 300041, Timișoara, Romania
4.“Victor Babes" University of Medicine and Pharmacy Timișoara, Faculty of Medicine, Department of Medical Chirurgical Semiotics, 2 Eftimie Murgu Street, 300041, Timișoara, Romania
5.“Victor Babes" University of Medicine and Pharmacy Timișoara, Faculty of Medicine, Department of Cardiology VI, 2 Eftimie Murgu Street, 300041, Timișoara, Romania
6.Bioclinica Laboratory SA, 53 Cetatii Boulevard, 300654, Timișoara, Romania

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Long pentraxin 3 (PTX3) is a new multimeric inflammatory biomarker, from the family of pentraxins, as well as C-reactive protein (CRP). PTX3 is produced at the sites of inflammation like vascular endothelial cells and leukocytes, while CRP is produced by hepatocytes. Having as a starting point the link between hypertension, inflammation and endothelial dysfunction, we aimed to compare the influence of perindopril versus other antihypertensive drugs on these biomarkers, in hypertensive patients with endothelial dysfunction. Our results showed that hypertensive patients treated with perindopril have lower levels of PTX3, suggesting the fact that the vascular inflammation is better controlled by perindopril than by other classes of antihypertensive drugs, like beta blockers, calcium channel blockers, or diuretics.