Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS OF SOME NEW 4-METHYL-2-(4-PYRIDYL)-THIAZOLE- 5-YL-AZOLES AS POTENTIAL ANTIMICROBIAL AGENTS

SMARANDA ONIGA1, MIHAELA DUMA2, OVIDIU ONIGA1*, BRINDUSA TIPERCIUC1, ADRIAN PIRNAU3, CĂTĂLIN ARANICIU1, MARIANA PALAGE1

1.Iuliu Hatieganu University of Medicine and Pharmacy, Dept. of Therapeutic Chemistry, 12 Ion Creanga Street, 400010 Cluj-Napoca, Romania
2.State Veterinary Laboratory for Animal Health and Food Safety, 1 Marasti Square, 400117, Cluj-Napoca, Romania
3.National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Street, 400293 Cluj-Napoca, Romania

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A new series of 4-methyl-2-(pyridin-4-yl)-thiazole-5-yl-azoles were synthesized starting from 4-methyl-2-(pyridin-4-yl)- thiazole-5-carbohydrazide. The newly synthesized compounds were characterized by analytical 1H NMR, 13C NMR and mass spectral data. The synthesized compounds were screened for their antimicrobial activities against several strains of Grampositive and Gram-negative bacteria and one fungal strain (Candida albicans).