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SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF NOVEL DIBENZOTHIEPINES

CAMELIA ELENA STECOZA 1, CONSTANTIN DRĂGHICI 2, MIRON TEODOR CĂPROIU 2, GRAȚIELA GRĂDIȘTEANU PÎRCĂLĂBIORU 3*, LUMINIȚA MĂRUȚESCU 3

1.“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 6 Traian Vuia Street, 020956, Bucharest, Romania
2.“Costin D. Neniţescu” Centre of Organic Chemistry Romanian Academy, 202 B Splaiul Independenţei, 060023, Bucharest, Romania
3.Research Institute of University of Bucharest, 60101, Bucharest, Romania

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Considering the anti-infective potential of compounds containing the dibenzothiepine scaffold, we set out to obtain new compounds bearing this structure. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their microbiostatic/microbicidal and antibiofilm properties against reference and clinical microbial strains. The new compounds exhibited a broad spectrum of antimicrobial activity, which was more intensive for the S-oxidized compounds. Some of the compounds also inhibited the ability of the investigated strains to form biofilms on the inert substratum.