Romanian Society of Pharmaceutical Sciences
 

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SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME NEW 2-(3-PYRIDIL)-THIAZOLYL-1,3,4-OXADIAZOLINES

SMARANDA DAFINA ONIGA 1, CĂTĂLIN ARANICIU 1*, CRISTINA IOANA STOICA 1, MARIANA DOINA PALAGE 1, LAURIAN VLASE 2, ADRIAN PIRNAU 3, LUMINIȚA MARUȚESCU 4,5, MARIANA CARMEN CHIFIRIUC 4,5, OVIDIU ONIGA 6

1.“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Therapeutic Chemistry, 12 Ion Creangă Street, 400010, Cluj-Napoca, Romania
2.“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmacy, 41 Victor Babeș Street, 400012, Cluj-Napoca, Romania
3.National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donat Street, 400293, Cluj-Napoca, Romania
4.University of Bucharest, Faculty of Biology, Department of Microbiology, 1-3 Portocalelor Street, 60101, Bucharest, Romania
5.Research Institute of the University of Bucharest - ICUB, 91-95 Independenței Street, Bucharest, Romania
6.“Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 41 Victor Babeș Street, 400012, Cluj-Napoca, Romania

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A new series of 4-methyl-2-(pyridin-3-yl)-thiazole-5-yl-oxadiazolines were synthesized starting from 4-methyl-2-(pyridin-3-yl)thiazole-5-carbohydrazide. The newly synthesized compounds were characterized by analytical 1H-NMR, 13C-NMR and mass spectral data. These compounds were screened for their antimicrobial activity against Gram-positive and Gram-negative bacterial strains and one fungal strain (Candida albicans).